- Lactubacillus are reduced in chronic stress conditions, Can Lactobacillus probiotics relieve chronic stress?
Shared Reference Notes
[1.1] - Two species from Lactobacillus genus ( Lactobacillus johnsonii, Lactobacillus gasseri) act upon mitochondria in the liver leading to the improvement of lipid metabolism.
- Metabolomics analyses revealed that reduced glutathione may mediate these effects.
- The mice receiving those Lactobacilli also had a lower fat mass index than those fed only a western diet
[1.2] - The glutamate decarboxylase gen in some LAB strains is a potential GABA producer.
- There are varying levels of inhibition against fungi, with Lactiplantibacillus plantarum and Lentilactobacillus parabuchneri exhibiting the highest suppression against the some strains of Fusarium, Aspergillus, and Penicillium.
- The antifungal activity is mainly due to the activity of acids produced by LAB.
- The antibacillus activity reveals a high inhibition potential of the majority of LAB isolated from sourdough against some strains of Bacillus.
[1.3] - Lactobacillus can resist the antimicrobial activity of bile salts.
[1.4] - Smectite clay promotes lactic acid bacteria (LABs) to form biofilms on its surface
- Smectite with LABs inhibits tumor growth in mice
- Smectite with LABs enhances anti-#Cancer chemo/immunotherapy in mice
- Smectite with LABs activates dendritic cells via TLR2 signaling
[1.6] [#Polycystic ovary syndrome] - Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased Lactobacillus and #Clostridium species and decreased #Prevotella.
[1.7] - A diet rich in salt (i.e. #High salt diet, or HSD) for instance, can result in depletion of the gut bacteria Lactobacillus spp., which results in T helper cell-mediated immune dysregulation and cognitive dysfunction.
- A diet rich do not increase the serum concentration of proinflammatory molecules.
- Adult male offspring from HSD-fed mice show hyperactivity, reduced sociability and increased repetitive behaviors
[1.8] [#Fermented food] - The excellent biological activities of these functional foods, such as anti-inflammatory and immunomodulatory functions, are widely attributable to their high antioxidant content and lactic acid-producing bacteria
[#Vaginally delivery] - Gamma aminobutyrate (#GABA), a major CNS inhibitory neurotransmitter, is produced from Lactobacillus and is the first bacterium that is colonized with most vaginally born infants.
[#Diabetes Type 2] - Lactobacillus > positively correlated with fasting glucose and HbA1c levels > increased insulin resistance.
[1.11] [#Fermented food] Fermented soymilk with various lactic acid bacteria > Reducing the content of phytic acid > Increasing the bioavailability of magnesium, calcium, iron and zinc
[1.12] [#Lactoferrin] - LF > iron donor to support the growth of some bacteria with lower iron demands > Lactobacillus sp. or #Bifidobacterium sp.
[1.14] [#Antibiotic Therapy] - Macrolide exposure was associated with reduced richness for twice as long as penicillin.
- Antbiotic at childhud > reduced #Bifidobacteria (5 studies) and Lactobacillus (2 studies), and significant increases in #Proteobacteria such as E. coli (4 studies).
[1.17] [#Hypertension] [#High salt diet] - Salt consumption decreased Lactobacillus abundance, which was linked to increased T helper 17 cell numbers in murine small intestinal lamina propria lymphocytes and human peripheral blood lymphocytes, as well as higher blood pressure.
- a high-salt diet reduced Lactobacillus abundance, increased proinflammatory gene expression, and exacerbated #Colitis in two separate disease models
[1.18] [#Inflamatory bowel disease] - studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as #Bifidobacterium, Lactobacillus, and #Akkermansia.
- the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself.
[1.19] - #Allicin (diallylthiosulfinate) is a natural food compound with multiple biological and pharmacological functions.
- #Allicin treatment significantly improved GM composition and induced the most significant alteration enrichment of #Bifidobacterium and Lactobacillus.
- #Allicin-induced GM to HFD mice (AGMT) significantly increased Blautia [short-chain fatty acids (SCFAs)-producing microbiota] and #Bifidobacterium in HFD mice, also increased the SCFAs in the cecum,
[#Parkinson’s Disease] - most PD patients (about 70% of patients) develop gastrointestinal disorders such as constipation, dysphagia, and gastroesophageal reflux. Strikingly, these gastrointestinal dysfunctions (particularly constipation and delayed gastric emptying) can be detected up to 20 years prior to PD diagnosis.
- reduction in their number of #Prevotellaceae bacteria compared to controls. Strikingly, this alteration was associated with the severity of the motor symptoms.
- PD patients may exhibit not only a decreased abundance of Prevotella but also an increased abundance of Lactobacilliceae.
- These alterations may be associated with reduced levels of #Ghrelin, an important gut hormone involved in the survival and efficacy of dopaminergic neurons.
[1.22] [#Culinary herbs and spices] - six of seven aqueous culinary spice extracts of oregano, ginger, rosemary, cinnamon, black pepper and cayenne pepper were able to promote the growth of #Bifidobacterium spp. in vitro, whereas turmeric was not.
- stimulation of Lactobacillus spp. and inhibition of certain #Clostridium spp. by all seven spices.
- increase in most #Clostridium spp. after turmeric and curcumin intervention in a human study.
- high consumption compared to low consumption of #Cocoa derived flavanols, significantly stimulated growth of #Bifidobacterium spp. and Lactobacillus spp.
[1.23] - the genus Lactobacillus are also “psychobiotics” and can modulate the gut–brain connection via neuroactive molecules (GABA, glutamate)
[1.24] [#Parkinson’s Disease] - #Bifidobacterium and Lactobacillus species, which are common constituents of commercial probiotics, were more abundant in PD than NHC metagenomes.
[1.28] [#Vaginal microbiota, #Vulvovaginal candidiasis] [#Candida albicans] - Lactobacillus spp. produces lactic and other organic acids that contribute to the low pH within the vaginal cavity.
- Low pH (< 4.5) inhibits C. albicans yeast-to-hypha transition.
[#Infants] Greater proportions of #Palmitic acid in the pool of triacylglycerides, for instance > higher levels of fecal Lactobacillus and #Bifidobacterium in neonates.
- #Oleic acid is beneficial for Lactobacillus spp.
[1.31] [#Rheumatoid Arthritis] - overabundance of #Prevotella copri in early RA patients
- proliferation of the genus Collinsela and some Lactobacillus species.
- Three mechanisms by which microbiota may contribute to RA pathogenesis were proposed: inflammatory responses (#Prevotella copri and Lactobacillus), molecular mimicry (#Prevotella copri) and loss of intestinal barrier integrity (#Collinsella).
[1.34] [#Anorexia nervosa] - At the genus level, elevated Lactobacillus counts were observed in the AN microbiota.
[1.35] - increased diversity of #Vaginal microbiota and reduced abundance of Lactobacillus spp. contribute to #HPV acquisition, persistence, and development of #Cervical cancer.
- In neurodegenerative diseases > #Histamine and other important #Neurotransmitters were synthesized in reduced amounts by the microbes with an elevated population in the diseased state.
- Most of the microbes, except #Desulfovibrio, Lactobacillus, and #Streptococcus, showed no annotation in their #Genome to synthesize #Histamine.
- in neurodegenerative disease > #Shigella, Lactobacillus, and #Streptococcus are such microbes with elevated populations and the highest PS for the #Putrescine III biosynthetic pathway.
[1.39] [#Bladder cancer] [#Lactobacillus crispatus] - Lactobacillus spp were significantly enriched in the #BCG responders. Co-culture with increasing concentrations of Lactobacillus crispatus resulted in increased #BCG-GFP internalization in UCC when compared to controls
[#Short peptide bacteriocins] - #Lactocillin, a thiopeptide SPB isolated from a vaginal commensal lactobacillus was shown to inhibit several pathogens colonising skin or vagina and showed no antimicrobial activity against other #Lactobacilli species
[1.41] [#Cognitive impairment, #Mild Cognitive Impairment] [#Bacteriophage] - higher abundance of Lactobacillus phages (family #Siphoviridae of the order #Caudovirales positively associated with better cognitive function; and transplantation of these phages from humans to mice and Drosophila showed increased memory scores and upregulation of memory-involved brain genes.
[1.42] - Extra-virgin #Olive oil ingestion in rodents also can promote the growth of certain types of beneficial #Bacteria including species of Lactobacillus, #Bifidobacterium, #Bacteroides, and #Clostridium, and members of the Erysipelotrichaeae.
[#Short Chain Fatty Acid] [#Olive] - SCFAs, produced by a number of bacteria, such as #Bacteroides and Lactobacillus, which are often elevated with EVOO consumption, are also potent activators for GPR43
- Lactobacillus to lower plasma #Cholesterol levels may be due partly to the enhanced #Bile Salt hydrolase activity this genus exhibits, as well as the ability to convert #Cholesterol to #Coprostanol, both leading to an impairment of #Cholesterol absorption in the intestine.
[#Olive] - Lactobacillus, also elevated with EVOO consumption25,29 when administered in #Probiotic form, promoted a significant reduction in plasma total #Cholesterol levels in mice as well as human patients with hypercholesterolemia.
[#Obesity] [#Olive] - in humans, EVOO has prebiotic effects, promoting the growth of beneficial bacteria such as Lactobacillus and #Bifidobacterium. Specifically, a #Mediterranean diet supplemented with 40 g/day EVOO for 3 months administered to 18 overweight/obese participants resulted in significantly increased levels of #Lactic acid bacteria compared to baseline.
[1.43] [#Polysaccharide] - #Cessation of breastfeeding initiates the transition towards an #Adult-like gut microbiome composition, which is characterized by expansion of #Roseburia spp. and #Anaerostipes spp., restriction of Lactobacillus spp. and a functional shift towards an increased capacity to degrade complex polysaccharides
[1.44] [#Celiac Disease] - #Bacillus subtilis LZU-GM was isolated from Pakistani traditional fermented sourdough and could degrade 73.7% of #Gluten in 24 h in vitro.
- The #Gluten degradation was 3-fold higher in the small intestine of the strain LZU-GM treated mice group.
- #Gluten-treated mice established positive antigliadin antibodies (AGA) in serum (IgA, IgG, and anti-TG2 antibodies) as compared to the strain LZU-GM treatment group.
- the number of IFN-γ, TNF-α, #IL-10, and COX-2 cells decrease in the lamina propria of the strain LZU-GM treatment group.
- Microbial community bar plot analysis showed that Lactobacillus, #Dubosiella, and #Enterococcus genera were restored and stabilized in the LZU-GM treatment group while #Blautia and #Ruminococcus were found lower.
[1.45] - The #Firmicutes phylum comprises Gram-positive bacteria with low G + C DNA content and is composed of more than 200 different genera, such as Lactobacillus, #Bacillus, #Clostridium, #Enterococcus, and Ruminicoccus.
[#Peripheral neuropathy] - Lactobacillus, #Lachnoclostridium, and #Anaerotruncus, correlated negatively with several free fatty acid and complex lipid species, including LysoPC 16:1, in both plasma and sciatic nerve.
[1.51] [#Systemic lupus erythematosus] - Lactobacillus treatment decreased #IL-6 and increased #IL-10 production in the gut contributing to an anti-inflammatory environment.
[1.52] [#Colorectal cancer] [#Short Chain Fatty Acid] [#Zizyphus jujuba cv. Muzao] -ZMP consumption prevented CRC mouse colon shortening, decreased their mortality, reduced pro-inflammatory cytokines, increased the concentration of total short-chain fatty acids (SCFAs) and modulated gut microbiota in their feces.
- ZMP also increased the richness of #Bifidobacterium, #Bacteroides and Lactobacillus.
[#Autism] - the levels of #Bifidobacterium (known as beneficial bacteria, such as Lactobacillus species) were significantly lower in the stool of #Children with ASD
- After probiotic supplementation, there was a significant increase in the colony counts of #Bifidobacterium and Lactobacillus with significant improvement in the severity of ASD and gastrointestinal symptoms.
- enterobacterial metabolite #Norharman, which was partly exogenous and generated from #Tryptophan metabolism regulated by Lactobacillus, showed the strongest inhibitory effect on M1 macrophage activation.
- As a neuroactive β-carboline, #Norharman is a pyridoindole alkaloid that is naturally occurring, is plant-derived or in thermally processed foods, and is formed by the condensation of indoleamine (such as #Tryptamine) and formaldehyde, showing antioxidant, anti-inflammatory, and antitumor activities
[1.62] - Gut bacteria, specifically of the genera #Bifidobacterium, #Clostridium, and Lactobacillus, can produce enzymes such as β-glucuronidases that modify excreted estrogens, causing them to be retained in the body via reabsorption into circulation. This leads to increased #Estrogen levels which can cause several hormone-linked diseases.
[1.65] - #Ginger essential oil supplementation in PL mice enhanced the relative abundance of Lactobacillus, #Alistipes, and #Olsenella, which are considered beneficial bacteria.
[1.66] - Although 5-aminosalicylates affect the host gut pH and promote the growth of #Bifidobacterium and Lactobacillus, and #Wheat consumption has also been linked to their enrichment.
[#Genome] - In addition to #Bifidobacterium and Lactobacillus, our study found a significant enrichment of #Streptococcus, a #Lactic acid-producing bacteria, in patients with #Ulcerative Colitis (UC).
- This is in contrast to the majority of earlier studies from west.
- This increase in #Streptococcus abundance has also been observed in UC patients from different populations.
[#Ulcerative Colitis] - increased abundance of #Nitrate-reducing bacteria in UC patients.
- persistent inflammation in UC patients accumulates nonfermentable #Nitrate.
- #Bifidobacterium and Lactobacillus can utilize nonfermentable forms of #Nitrate.
[#Alzheimer’s disease] - co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, #Tau phosphorylation, and #Cognitive impairment.
- Gavage with Lactobacillus and #Bifidobacterium restored these changes.
[1.71] [#Lachnospiraceae] [#Fiber-free diet] - The lack of dietary fiber > reduced abundances of the #Butyrate-producing genera Lachnospiraceaea NK4A136 and #Roseburia. Additionally, Lactobacillus, which was also reduced in Fibre deprived mice
[1.72] [#Osteopontin] - OPN could reduce the colonization of Lactobacillus in the intestine of mice and promote the abundance of #Dorea, which could further regulate metabolic disorders
[1.74] [#Non alcoholic steatohepatitis] [#Probiotic] - Probiotics, such as #Bifidobacterium and Lactobacillus strains, have been shown to reduce oxidative and inflammatory liver damage while also decreasing hepatic triglycerides (TG) and hepatic steatosis.
[1.75] - Lactobacillus was demonstrated to enhance antigen-specific IgA secretion and induce Tfh cells in mice
[1.76] - #Bifidobacterium and Lactobacillus spp. can convert #Arginine to #Glutamic acid, which is deaminated to aminobutyric acid (#GABA), a key inhibitory neurotransmitter of the CNS
- Lactobacillus, #Enterococcus, #Clostridium, and #Proteus are gastrointestinal tract (GIT) bacteria that can use the #Triglyceride backbone as an electron sink, reducing glycerol to 1,3-propanediol
[#Triglyceride] - #3-hydroxypropanal (reuterin), was discovered to be extracellularly accumulated in Lactobacillus and #Enterococcus cultures.
- Reuterin has antimicrobial properties that act on both pathogens and commensals, and it can be dehydrated spontaneously to acrolein, a highly reactive genotoxic with the same mutagenic potency as formaldehyde.
[1.77] [#Hypercholesterolaemia] - Lactobacillus and #Bifidobacterium, which act as beneficial bacteria in the gut, contribute to the prevention of diseases such as hypercholesterolemia
- The small intestine’s microbiota has fewer types and numbers than the colon, including Lactobacillus
