Lactobacillaceae ⇒ Lactobacillus {10000118} Record Keys Parent:Lactobacillaceae Definition:Lactobacillus Details Initialisation date:2019-06-23 LinksSource Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: - Lactubacillus are reduced in chronic stress conditions, Can Lactobacillus probiotics relieve chronic stress?Shared Reference Notes [1.1] - Two species from Lactobacillus genus ( Lactobacillus johnsonii, Lactobacillus gasseri) act upon mitochondria in the liver leading to the improvement of lipid metabolism. - Metabolomics analyses revealed that reduced glutathione may mediate these effects. - The mice receiving those Lactobacilli also had a lower fat mass index than those fed only a western diet [1.2] - The glutamate decarboxylase gen in some LAB strains is a potential GABA producer. - There are varying levels of inhibition against fungi, with Lactiplantibacillus plantarum and Lentilactobacillus parabuchneri exhibiting the highest suppression against the some strains of Fusarium, Aspergillus, and Penicillium. - The antifungal activity is mainly due to the activity of acids produced by LAB. - The antibacillus activity reveals a high inhibition potential of the majority of LAB isolated from sourdough against some strains of Bacillus. [1.3] - Lactobacillus can resist the antimicrobial activity of bile salts. [1.4] - Smectite clay promotes lactic acid bacteria (LABs) to form biofilms on its surface - Smectite with LABs inhibits tumor growth in mice - Smectite with LABs enhances anti-#Cancer chemo/immunotherapy in mice - Smectite with LABs activates dendritic cells via TLR2 signaling [1.5] [#Probiotic (Bifidobacter and Lactobacilus)] - The administration of a probiotic cocktail, composed of Lactobacillus rhamnosus and Lactobacillus helveticus, reduced the symptoms of #Depression and anxiety - Following an extremely stressful period, fewer species of Lactobacillus are present in the stool. - Lactobacillus can produce #Acetylcholine - Lactobacillus can produce #GABA [1.6] [#Polycystic ovary syndrome] - Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased Lactobacillus and #Clostridium species and decreased #Prevotella. [1.7] - A diet rich in salt (i.e. #High salt diet, or HSD) for instance, can result in depletion of the gut bacteria Lactobacillus spp., which results in T helper cell-mediated immune dysregulation and cognitive dysfunction. - A diet rich do not increase the serum concentration of proinflammatory molecules. - Adult male offspring from HSD-fed mice show hyperactivity, reduced sociability and increased repetitive behaviors [1.8] [#Fermented food] - The excellent biological activities of these functional foods, such as anti-inflammatory and immunomodulatory functions, are widely attributable to their high antioxidant content and lactic acid-producing bacteria [1.9] - #Acetylcholine is produced from Lactobacillus [#Vaginally delivery] - Gamma aminobutyrate (#GABA), a major CNS inhibitory neurotransmitter, is produced from Lactobacillus and is the first bacterium that is colonized with most vaginally born infants. [#Diabetes Type 2] - Lactobacillus > positively correlated with fasting glucose and HbA1c levels > increased insulin resistance. [1.11] [#Fermented food] Fermented soymilk with various lactic acid bacteria > Reducing the content of phytic acid > Increasing the bioavailability of magnesium, calcium, iron and zinc [1.12] [#Lactoferrin] - LF > iron donor to support the growth of some bacteria with lower iron demands > Lactobacillus sp. or #Bifidobacterium sp. [1.13] [#Parkinson’s Disease] [#Bifidobacterium adolescentis] - PD patients, showing an increase in #Akkermansia, Bifidobacterium, and Lactobacillus and a decrease in #Prevotella [1.14] [#Antibiotic Therapy] - Macrolide exposure was associated with reduced richness for twice as long as penicillin. - Antbiotic at childhud > reduced #Bifidobacteria (5 studies) and Lactobacillus (2 studies), and significant increases in #Proteobacteria such as E. coli (4 studies). [1.15] [#Pancreatic Cancer] [#Indole, #Tryptophan] [#Probiotic] [1.16] [#Ulcerative Colitis] - during active UC, anti-inflammatory Lactobacillus and #Pediococcus acidilactici were absent in fecal samples [1.17] [#Hypertension] [#High salt diet] - Salt consumption decreased Lactobacillus abundance, which was linked to increased T helper 17 cell numbers in murine small intestinal lamina propria lymphocytes and human peripheral blood lymphocytes, as well as higher blood pressure. - a high-salt diet reduced Lactobacillus abundance, increased proinflammatory gene expression, and exacerbated #Colitis in two separate disease models [1.18] [#Inflamatory bowel disease] - studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as #Bifidobacterium, Lactobacillus, and #Akkermansia. - the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself. [1.19] - #Allicin (diallylthiosulfinate) is a natural food compound with multiple biological and pharmacological functions. - #Allicin treatment significantly improved GM composition and induced the most significant alteration enrichment of #Bifidobacterium and Lactobacillus. - #Allicin-induced GM to HFD mice (AGMT) significantly increased Blautia [short-chain fatty acids (SCFAs)-producing microbiota] and #Bifidobacterium in HFD mice, also increased the SCFAs in the cecum, [#Parkinson’s Disease] - most PD patients (about 70% of patients) develop gastrointestinal disorders such as constipation, dysphagia, and gastroesophageal reflux. Strikingly, these gastrointestinal dysfunctions (particularly constipation and delayed gastric emptying) can be detected up to 20 years prior to PD diagnosis. - reduction in their number of #Prevotellaceae bacteria compared to controls. Strikingly, this alteration was associated with the severity of the motor symptoms. - PD patients may exhibit not only a decreased abundance of Prevotella but also an increased abundance of Lactobacilliceae. - These alterations may be associated with reduced levels of #Ghrelin, an important gut hormone involved in the survival and efficacy of dopaminergic neurons. [1.21] [#Natural Skin Microbiome] [#Gender] - female genital tract is characterized by a predominance of Lactobacillus. [1.22] [#Culinary herbs and spices] - six of seven aqueous culinary spice extracts of oregano, ginger, rosemary, cinnamon, black pepper and cayenne pepper were able to promote the growth of #Bifidobacterium spp. in vitro, whereas turmeric was not. - stimulation of Lactobacillus spp. and inhibition of certain #Clostridium spp. by all seven spices. - increase in most #Clostridium spp. after turmeric and curcumin intervention in a human study. - high consumption compared to low consumption of #Cocoa derived flavanols, significantly stimulated growth of #Bifidobacterium spp. and Lactobacillus spp. [1.23] - the genus Lactobacillus are also “psychobiotics” and can modulate the gut–brain connection via neuroactive molecules (GABA, glutamate) [1.24] [#Parkinson’s Disease] - #Bifidobacterium and Lactobacillus species, which are common constituents of commercial probiotics, were more abundant in PD than NHC metagenomes. [1.25] [#Parkinson’s Disease] - PD > increased relative abundance of family Enterobacteriaceae, genera #Akkermansia, Lactobacillus, #Bifidobacterium. - PD > decreased relative abundance of family #Lachnospiraceae, #Faecalibacterium [1.26] [#Polyphenol-rich supplementation] - Polyphenols supplementation significantly increase the Lactobacillus by 220% and #Bifidobacterium by 56% (mostly anthocyanins). - [1.27] - it seems to exist a negative correlation between Lactobacillus and #Bifidobacterium counts with #Sleep and cortisol levels respectively [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] - Gut microbiota in BD, MDD and SZ > increase in #Eggerthella and Lactobacillus, together with a decrease in #Coprococcus was common for the three conditions in comparison to controls. [1.28] [#Vaginal microbiota, #Vulvovaginal candidiasis] [#Candida albicans] - Lactobacillus spp. produces lactic and other organic acids that contribute to the low pH within the vaginal cavity. - Low pH (< 4.5) inhibits C. albicans yeast-to-hypha transition. [1.29] [#High-protein diet] - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, Lactobacillus, #Bifidobacterium, #Prevotella, #Ruminococcus, #Roseburia, and #Faecalibacterium. [#Infants] - Bacterial genera commonly found in the infant small intestine include Lactobacillus, #Clostridium, #Staphylococcus, #Streptococcus, #Bacteroides, and #Bifidobacterium [#Infants] Greater proportions of #Palmitic acid in the pool of triacylglycerides, for instance > higher levels of fecal Lactobacillus and #Bifidobacterium in neonates. - #Oleic acid is beneficial for Lactobacillus spp. [1.31] [#Rheumatoid Arthritis] - overabundance of #Prevotella copri in early RA patients - proliferation of the genus Collinsela and some Lactobacillus species. - Three mechanisms by which microbiota may contribute to RA pathogenesis were proposed: inflammatory responses (#Prevotella copri and Lactobacillus), molecular mimicry (#Prevotella copri) and loss of intestinal barrier integrity (#Collinsella). [1.32] - good immunological and metabolic health-related bacteria, such as #Akkermansia, #Christensenellaceae, and Lactobacillus, were higher in #Centenarians than in other groups [#Aging] - the loss of Lactobacillus and #Faecalibacterium, as well as the abundance of #Oscillibacter and #Alistipes genera along with the #Eubacteriaceae family is linked to #Frailty in elderly people. [1.33] - #Bifidobacteria and Lactobacillus spp. can produce micromolar concentrations of #GABA. - #Grape seed > the growth of Lactobacillus and #Enterococcus spp. were elevated. - These changes in the gut microbiota were associated with increases in #4-hydroxyphenylacetic acid, #Phenylpropionic acid, #Phenylacetic acid and #4-hydroxybenzoic acid - #Ferulic acid is a #Hydroxycinnaminic acid produced as a microbial metabolite from several Lactobacillus species and the production of many of its bioactive metabolic products (#Dihydroferulic acid or #Vanillic acid) is dependent on the gut microbiota. [1.34] [#Anorexia nervosa] - At the genus level, elevated Lactobacillus counts were observed in the AN microbiota. [1.35] - increased diversity of #Vaginal microbiota and reduced abundance of Lactobacillus spp. contribute to #HPV acquisition, persistence, and development of #Cervical cancer. [1.36] - in neurodegenerative disease > The microbes with elevated populations, like #Bilophila, Butryicicoccus, #Alistipes, #Enterococcus, Lactobacillus, #Streptococcus, #Shigella, and #Desulfovibrio, have the metabolic capability to produce #Putrescine majorly by the #Putrescine III biosynthesis pathway. - In neurodegenerative diseases > #Histamine and other important #Neurotransmitters were synthesized in reduced amounts by the microbes with an elevated population in the diseased state. - Most of the microbes, except #Desulfovibrio, Lactobacillus, and #Streptococcus, showed no annotation in their #Genome to synthesize #Histamine. - #Enterococcus and Lactobacillus had the highest PS for #Butyrate formation through the fermentation of #Pyruvate. - in neurodegenerative disease > #Shigella, Lactobacillus, and #Streptococcus are such microbes with elevated populations and the highest PS for the #Putrescine III biosynthetic pathway. [1.37] [#Natural Small intestine Microbiome] [#Escherichia coli] - At the genus level, bacteria highly abundant in the SI include Lactobacillus, #Veillonella, #Streptococcus, #Gemella, #Actinomyces, and E. coli. [#Natural Small intestine Microbiome] - Only select bacteria, including #Clostridium, Lactobacillus, and #Enterococcus species, are able to penetrate, or attach to, the mucus layer at the epithelium and use the mucus as an energy source [1.38] [#humanized Galactooligosaccharides] - Lactobacillus and #Bifidobacterium specialize in oligosaccharide fermentation, utilizing galactooligosaccharides (GOS), #Fructooligosaccharides (FOS), and #Polysaccharide #Inulin [1.39] [#Bladder cancer] [#Lactobacillus crispatus] - Lactobacillus spp were significantly enriched in the #BCG responders. Co-culture with increasing concentrations of Lactobacillus crispatus resulted in increased #BCG-GFP internalization in UCC when compared to controls [#Short peptide bacteriocins] - #Lactocillin, a thiopeptide SPB isolated from a vaginal commensal lactobacillus was shown to inhibit several pathogens colonising skin or vagina and showed no antimicrobial activity against other #Lactobacilli species [1.41] [#Cognitive impairment, #Mild Cognitive Impairment] [#Bacteriophage] - higher abundance of Lactobacillus phages (family #Siphoviridae of the order #Caudovirales positively associated with better cognitive function; and transplantation of these phages from humans to mice and Drosophila showed increased memory scores and upregulation of memory-involved brain genes. [1.42] - Extra-virgin #Olive oil ingestion in rodents also can promote the growth of certain types of beneficial #Bacteria including species of Lactobacillus, #Bifidobacterium, #Bacteroides, and #Clostridium, and members of the Erysipelotrichaeae. [#Short Chain Fatty Acid] [#Olive] - SCFAs, produced by a number of bacteria, such as #Bacteroides and Lactobacillus, which are often elevated with EVOO consumption, are also potent activators for GPR43 - Lactobacillus to lower plasma #Cholesterol levels may be due partly to the enhanced #Bile Salt hydrolase activity this genus exhibits, as well as the ability to convert #Cholesterol to #Coprostanol, both leading to an impairment of #Cholesterol absorption in the intestine. [#Olive] - Lactobacillus, also elevated with EVOO consumption25,29 when administered in #Probiotic form, promoted a significant reduction in plasma total #Cholesterol levels in mice as well as human patients with hypercholesterolemia. [#Obesity] [#Olive] - in humans, EVOO has prebiotic effects, promoting the growth of beneficial bacteria such as Lactobacillus and #Bifidobacterium. Specifically, a #Mediterranean diet supplemented with 40 g/day EVOO for 3 months administered to 18 overweight/obese participants resulted in significantly increased levels of #Lactic acid bacteria compared to baseline. [1.43] [#Polysaccharide] - #Cessation of breastfeeding initiates the transition towards an #Adult-like gut microbiome composition, which is characterized by expansion of #Roseburia spp. and #Anaerostipes spp., restriction of Lactobacillus spp. and a functional shift towards an increased capacity to degrade complex polysaccharides [1.44] [#Celiac Disease] - #Bacillus subtilis LZU-GM was isolated from Pakistani traditional fermented sourdough and could degrade 73.7% of #Gluten in 24 h in vitro. - The #Gluten degradation was 3-fold higher in the small intestine of the strain LZU-GM treated mice group. - #Gluten-treated mice established positive antigliadin antibodies (AGA) in serum (IgA, IgG, and anti-TG2 antibodies) as compared to the strain LZU-GM treatment group. - the number of IFN-γ, TNF-α, #IL-10, and COX-2 cells decrease in the lamina propria of the strain LZU-GM treatment group. - Microbial community bar plot analysis showed that Lactobacillus, #Dubosiella, and #Enterococcus genera were restored and stabilized in the LZU-GM treatment group while #Blautia and #Ruminococcus were found lower. [1.45] - The #Firmicutes phylum comprises Gram-positive bacteria with low G + C DNA content and is composed of more than 200 different genera, such as Lactobacillus, #Bacillus, #Clostridium, #Enterococcus, and Ruminicoccus. [#Diabetes Type 1] - Studies have reported an increased quantity of #Villanella, #Clostridium, and #Bacteroides and a decreased quantity of Lactobacillus, #Eubacterium rectale, #Blautia coccoides, and #Bifidobacterium in #Children with type 1 diabetes. - #Diabetes Type 1 > negative correlation has been reported between plasma #Glucose level and #Bifidobacterium, Lactobacillus spp., and #Firmicutes and #Bacteroidetes spp., while there has been positive correlation between #Clostridium and plasma #Glucose level. [1.46] [#Metabolic associated fatty liver disease] - #Dorea, Lactobacillus and #Megasphaera are enriched in MAFLD group. [1.47] [#Candida albicans, #Streptococcus mutans] - The presence of C. albicans would increase the abundance of #Streptococcus (particularly S. mutans), certain Lactobacillus species, and salivary #Veillonella and #Prevotella, and also increase the cariogenic virulence of biofilms [1.48] [#Postmenopausal osteoporosis] - the enrichment Lactobacillus sp. in non-PMO and the increased abundances of #Peptoniphilus sp., #Propionic acid bacteria, and members of the #Galicola genus in PMO [1.49] - #Leptin serum level was positively correlated with the abundance of #Bifidobacterium and #Lactobacillus whereas #Leptin serum level was negatively correlated with #Clostridium, #Bacteroides and, #Prevotella [#Postmenopausal] - Gut #Bacteria that possess β-glucuronidase and/or β-galactosidase activity can metabolize #Estrogen including #Bifidobacterium, #Faecalibacterium, Lactobacillus, #Veillonella [#Diabetes Type 2, #Peripheral neuropathy] [#Sphingomyelin] [#High Fat Diet] - Lactobacillus, #Lachnoclostridium, and #Anaerotruncus taxa variants positively correlated with several lipid species, particularly elevated plasma sphingomyelins and sciatic nerve triglycerides. [#Peripheral neuropathy] - Lactobacillus, #Lachnoclostridium, and #Anaerotruncus, correlated negatively with several free fatty acid and complex lipid species, including LysoPC 16:1, in both plasma and sciatic nerve. [1.51] [#Systemic lupus erythematosus] - Lactobacillus treatment decreased #IL-6 and increased #IL-10 production in the gut contributing to an anti-inflammatory environment. [1.52] [#Colorectal cancer] [#Short Chain Fatty Acid] [#Zizyphus jujuba cv. Muzao] -ZMP consumption prevented CRC mouse colon shortening, decreased their mortality, reduced pro-inflammatory cytokines, increased the concentration of total short-chain fatty acids (SCFAs) and modulated gut microbiota in their feces. - ZMP also increased the richness of #Bifidobacterium, #Bacteroides and Lactobacillus. [1.53] - 60 bacterial genera from human gut microbiota (#Bacteroides, #Bifidobacterium, #Escherichia, #Faecalibacterium, and Lactobacillus,) > encode β-glucuronidase and/or β-galactosidase > impacting endogenous #Estrogen metabolism [1.54] - certain #Bifidobacterium, #Bacteroides, and Lactobacillus species that have high activities of #Bile Salt hydrolase, the enzyme responsible for the deconjugation of #Bile Acids. [1.55] - Lactobacillus spp., which was prevalent in healthy controls’ microbiota, splitted #Gluten peptides, thus reducing their immunogenicity [1.56] [#Spondyloarthritis] - significant increases in the class #Bacilli, order #Lactobacillales, families #Lactobacillaceae and #Clostridiaceae, and genera Lactobacillus and #Clostridium in non-colonized SpA patients. [1.57] [#Alzheimer’s disease] - In AD > Gavage with Lactobacillus and #Bifidobacterium restored these changes in the wild-type mice. [1.58] [#Escherichia coli] - #Vitamin B12 supplementation in mice significantly decreased #Parabacteroides and Lactobacillus and increased E. coli and #Enterococcus abundances in a murine model of #Colitis [1.59] [#Attention Deficit Hyperactivity Disorder] - Lactobacillus and #Bifidobacterium producers of #GABA, which is known to decrease in patients with ADHD > Ameliorate ADHD [#Autism] - the levels of #Bifidobacterium (known as beneficial bacteria, such as Lactobacillus species) were significantly lower in the stool of #Children with ASD - After probiotic supplementation, there was a significant increase in the colony counts of #Bifidobacterium and Lactobacillus with significant improvement in the severity of ASD and gastrointestinal symptoms. - Lactobacillus species produce #Acetylcholine and #GABA - enterobacterial metabolite #Norharman, which was partly exogenous and generated from #Tryptophan metabolism regulated by Lactobacillus, showed the strongest inhibitory effect on M1 macrophage activation. - As a neuroactive β-carboline, #Norharman is a pyridoindole alkaloid that is naturally occurring, is plant-derived or in thermally processed foods, and is formed by the condensation of indoleamine (such as #Tryptamine) and formaldehyde, showing antioxidant, anti-inflammatory, and antitumor activities [1.61] [#Flavonoid] - flavanols can stimulate #Lactic acid bacteria. [1.62] - Gut bacteria, specifically of the genera #Bifidobacterium, #Clostridium, and Lactobacillus, can produce enzymes such as β-glucuronidases that modify excreted estrogens, causing them to be retained in the body via reabsorption into circulation. This leads to increased #Estrogen levels which can cause several hormone-linked diseases. [1.63] - Some oral bacteria belonging to genera Lactobacillus, #Lactococcus, #Bifidobacterium, #Streptococcus, #Leuconostoc, and #Pediococcus produce #Lactic acid [1.64] - patients with #Celiac Disease showed the abundance of #Streptococcus, Lactobacillus, #Veillonella, and #Allisonella species, while the abundance of #Ruminococcus, #Faecalibacterium, #Blautia, #Gemmiger, and #Anaerostipes was decreased. [1.65] - #Ginger essential oil supplementation in PL mice enhanced the relative abundance of Lactobacillus, #Alistipes, and #Olsenella, which are considered beneficial bacteria. [#Metabolic associated fatty liver disease] - Lactobacillus may be used as a #Probiotic to improve #Steatohepatitis through the gut microbiota–liver axis by modulating gut microbiota composition and the inflammatory pathway in NAFLD [1.66] - Although 5-aminosalicylates affect the host gut pH and promote the growth of #Bifidobacterium and Lactobacillus, and #Wheat consumption has also been linked to their enrichment. [#Genome] - In addition to #Bifidobacterium and Lactobacillus, our study found a significant enrichment of #Streptococcus, a #Lactic acid-producing bacteria, in patients with #Ulcerative Colitis (UC). - This is in contrast to the majority of earlier studies from west. - This increase in #Streptococcus abundance has also been observed in UC patients from different populations. [#Ulcerative Colitis] - increased abundance of #Nitrate-reducing bacteria in UC patients. - persistent inflammation in UC patients accumulates nonfermentable #Nitrate. - #Bifidobacterium and Lactobacillus can utilize nonfermentable forms of #Nitrate. [1.67] [#Indole-3-acetic acid] - Lactobacillus can use #Tryptophan instead of #Glucose as a source of energy, and produce #AHR ligands such as #Indole-3-acetic acid (IAA), #Tryptamine (TA) and 3-methyl #Indole [1.68] - #Sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, #Desulfovibrio, #Escherichia coli, #Fusobacterium, #Klebsiella, Lactobacillus, #Morganella, #Odoribacter, and #Proteus. [1.69] [#Bacteroides-Prevotella group, #Ruminococcus gauvreauii] [#Keto diet] - The abundance of Ruminococcus_gauvreauii_group, #Bacteroides, #Bifidobacterium, and #Blautia significantly increased, whereas that of Lactobacillus, #Romboutsia, #Facklamia, and #Turicibacter significantly declined in the KD group compared with the ND group. [#Alzheimer’s disease] - co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, #Tau phosphorylation, and #Cognitive impairment. - Gavage with Lactobacillus and #Bifidobacterium restored these changes. [1.71] [#Lachnospiraceae] [#Fiber-free diet] - The lack of dietary fiber > reduced abundances of the #Butyrate-producing genera Lachnospiraceaea NK4A136 and #Roseburia. Additionally, Lactobacillus, which was also reduced in Fibre deprived mice [1.72] [#Osteopontin] - OPN could reduce the colonization of Lactobacillus in the intestine of mice and promote the abundance of #Dorea, which could further regulate metabolic disorders [1.73] [#Parkinson’s Disease] - Lactobacillus and #Bifidobacterium genus were most abundant in PD patients. #Prevotella VZCB and other #Faecalibacterium were most abundant in controls. [1.74] [#Metabolic Dysfunction-associated Steatohepatitis] [#Probiotic] - Probiotics, such as #Bifidobacterium and Lactobacillus strains, have been shown to reduce oxidative and inflammatory liver damage while also decreasing hepatic triglycerides (TG) and hepatic steatosis. [1.75] - Lactobacillus was demonstrated to enhance antigen-specific IgA secretion and induce Tfh cells in mice [#Primary immune thrombocytopenia] - fecal bacteria such as #Actinomycetaceae, #Blautia, #Streptococcus, and Lactobacillus are enriched, whereas bacteria such as #Bacteroides are depleted in ITP patients. [#Primary immune thrombocytopenia] - lactobacillus might indeed play a key role in the progression of ITP. [#Primary immune thrombocytopenia] [#Streptococcus anginosus, #Streptococcus parasanguinis, #Streptococcus salivarius] - Lactobacillus and #Streptococcus (including S. anginosus, #Streptococcus sp., S. parasanguinis, and S. salivarius) were enriched in ITP patients. [1.76] - #Bifidobacterium and Lactobacillus spp. can convert #Arginine to #Glutamic acid, which is deaminated to aminobutyric acid (#GABA), a key inhibitory neurotransmitter of the CNS - Lactobacillus, #Enterococcus, #Clostridium, and #Proteus are gastrointestinal tract (GIT) bacteria that can use the #Triglyceride backbone as an electron sink, reducing glycerol to 1,3-propanediol [#Diabetes Type 2] - in T2DM patients > #Bifidobacterium, Lactobacillus, #Faecalibacterium prausnitzii, and #Butyrate-creating bacteria such as #Roseburia intestinalis and F. prausnitzii abundance decreased [#Triglyceride] - #3-hydroxypropanal (reuterin), was discovered to be extracellularly accumulated in Lactobacillus and #Enterococcus cultures. - Reuterin has antimicrobial properties that act on both pathogens and commensals, and it can be dehydrated spontaneously to acrolein, a highly reactive genotoxic with the same mutagenic potency as formaldehyde. [1.77] [#Hypercholesterolaemia] - Lactobacillus and #Bifidobacterium, which act as beneficial bacteria in the gut, contribute to the prevention of diseases such as hypercholesterolemia - The small intestine’s microbiota has fewer types and numbers than the colon, including Lactobacillus [1.78] [#Obesity] - weight loss is associated with reduced #Butyrate production by specific gut microbiota bacteria, such as the Lactobacillus and #Bifidobacterium genera belonging to the #Firmicutes phylum [1.79] - Lactobacillus, #Bacillus, #Corynebacterium, #Streptococcus, #Pseudomonas, #Staphylococcus, #Escherichia-#Shigella were observed to decrease in Viral #Keratitis microbiomes. And the abundance of some opportunistic pathogens such as #Rhodococcus were increased. - GM mainly controls #Estrogen levels through the secretion of an enzyme called β-glucuronidase, which is encoded by several GM genera, including #Bacteroides, #Bifidobacterium, #Escherichia, and Lactobacillus [1.81] [#Infants] - due to the reduced #Oxygen concentration,Citation38 anaerobic #Bacteria, i.e., Lentilactobacillus and Lactobacillus, emerge during the 8th to 12th month. [1.82] [#Biliary tract cancer, #Intrahepatic Cholangiocarcinoma, #Primary liver cancer] - enriched in ICC were #Actinomyces, Lactobacillus, #Peptostreptococcaceae, and #Alloscardovia. Furthermore, the #Glycoursodeoxycholic acid and #Tauroursodeoxycholic acid (TUDCA) plasma-stool ratios were significantly increased in ICC with the genera Lactobacillus and #Alloscardovia exhibiting positive correlations with the TUDCA plasma-stool ratio. - These biomarkers could be used to differentiate ICC from hepatocellular carcinoma (HCC) [1.83] [#Bladder cancer] - the #Howardella genus and the #Streptococcus anginosus strain were more common in women. - no differences in the diversity of urine between sexes; however, in the urine of women, there was a higher abundance of the genera Lactobacillus, Actinotignum, #Prevotella, #Veillonella, and #Campylobacter. - genus Lactobacillus was more frequently found in the urine of patients with a history of #BCG therapy. [1.84] - increased Lactobacillus is associated with TNF production and intestinal inflammation. [#Short Chain Fatty Acid] - genera Lactobacillus and #Megasphaera are increased in #Schizophrenia (SZ), as well as alterations in the #Glutamate-#Glutamine-#GABA cycle, serum levels of #Tryptophan, #kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). [1.85] - increase in #Lachnospiraceae, #Ruminococcaceae, and Lactobacillus species following #Beta-glucan treatment. [1.86] [#Covid-19] [#mRNA vaccine] - #Agathobacter, Lactobacillus, #Bacteroides, and #Lachnospira were positively correlated with both spike IgG levels and spike-specific CD4+ T-cell responses. These #Bacteria with known immunomodulatory properties could contribute to higher immune responses to vaccinations [1.87] [#Collagen-induced arthritis , #Rheumatoid Arthritis, #Spondyloarthritis] [#Lachnospiraceae bacterium] - in CIA (such as Lachnospiraciae and Lactobacillaeae), RA (#Lachnospiraceae bacterium, lactobacillus spp., #Faecalibacterium), and SpA (#Ruminococcaceae, #Rikenellaceae, #Porphyromonadaceae, #Bacteroidaceae, #Lachnospiraceae) are either predicted or known to produce #Indole [1.88] - levels of #Prevotella, #Dehalobacterium, #Ruminococcus, and Lactobacillus were found to be remarkably lower in rat model of #Hyperuricemia. [1.89] [#Chronic periodontitis] - the microbiomes of periodontitis patients contained a greater abundance of the genus #Acidaminococcus, #Clostridium, Lactobacillus, #Bifidobacterium, #Megasphaera, and Romboutsiac. [#Bisphenol A] - Lactobacillus and #Bacteroides were lost after BPA [1.91] [#Radiofrequency field] - Lactobacillus, the #Probiotic in #Firmicutes, showed a significantly increased abundance after 3 weeks RF exposure [1.92] [#Tryptophan] - Trp is converted to #Indole via the enzyme Trp identified in gut bacteria such as #Escherichia coli (E. coli), #Clostridium spp., and #Bacteroides spp. - Trp decarboxylase converts Trp to #Tryptamine > is expressed in #Clostridium, #Ruminococcus, #Blautia, and Lactobacillus bacteria [#Tryptophan] - a Trp rich diet was able to shift the gut microbial composition of mice toward the increased abundance of bacteria able to produce #AHR ligands such as Lactobacillus and #Ruminococcus gnavus, thus reducing #Gluten immunopathology. [1.93] [#Candida albicans] - The mechanisms that underlie the competition of Lactobacillae with C. albicans are manifold and include toxic metabolic products, biofilm interference, physical interactions, and forced metabolic adaptation that compromises the pathogenicity of C. albicans [1.94] [#Allergic rhinitis] - butyrylated #Starch significantly increased the levels of colonic #Butyrate, and downregulated serum OVA-sIgE, IL-4, and IL-5, and improved symptoms in AR mice. In addition, the proportion of Treg cells in mesenteric lymph nodes and the levels of #IL-10 and TGF-β in the serum were elevated after butyrylated #Starch intervention. - butyrylated #Starch promoted the enrichment of beneficial genera in AR mice, such as Lactobacillus, and alleviated the composition and structural disorder of gut microbiota in AR mice. [1.95] [#Mild Cognitive Impairment, #Parkinson’s Disease] [#Porphyromonas gingivalis] - The structures of oral microbiota in PD-MCI group were significantly different compared to that in PD-NC and PC group. The relative abundances of #Prevotella, Lactobacillus, #Megasphaera, #Atopobium, and #Howardella were negatively correlated with cognitive score. - The predominant Kgp genotypes of P. gingivalis in the PD-MCI group were primarily Kgp II, whereas in the PD-NC group, it was mainly Kgp I. - The Kgp II correlated with lower MMSE and MoCA scores, which suggested that Kgp genotypes II is related to cognitive impairment in PD. [1.96] [#Diabetes Type 2] - oral #Fusobacterium nucleatum and gut Lactobacillus are increased in in diabetic coronary heart disease (DCHD) patients, with a positive correlation between the two. - in hyperglycemic mice, augmented #Fusobacterium nucleatum levels in the oral cavity were accompanied by an imbalance in the oral-gut axis, characterized by an increased coexistence of #Fusobacterium nucleatum and Lactobacillus, along with elevated cardiac miRNA-21 and a greater extent of myocardial damage [1.97] [#Condition of chronic stress] - stressed animals had a decrease in the abundance of Lactobacillus after stress and continued with many groups showing that oral administration of a Lactobacillus #Probiotic can alleviate the #Anxiety- and #Depression-like behavior in a multitude of models [#Lactobacillus intestinalis, #Lactobacillus murinus] - mice raised with a known consortium of gut bacteria that contains L. intestinalis and L. murinus are more resistant to both acute stressor and more chronic mild stressors than mice without Lactobacillus. [1.98] - Four bacterial species, including #Ruminococcaceae UCG010, #Butyricimonas, #Pasteurellaceae and lactobacillus independently influence the development of various types of #Obesity. - In the case of extreme #Obesity with alveolar hypoventilation, lactobacillus reduced the risk of its occurrence. [1.99] - the topical application of Lactobacillus strains was shown to reduce inflammatory lesions related to #Acne, presumably through modulating the immune response [#Anthocyanins] - Subtle differences were observed in the faecal microbiota of subjects that were fed the different apples, with significant reductions in relative abundances of #Streptococcus, #Ruminococcus, #Blautia, and #Roseburia, and increased relative abundances of #Sutterella, #Butyricicoccus, and Lactobacillus in subjects after consuming the red #Apple. - anthocyanin-rich apples may influence immune function compared to control apples [1.101] [#Lactobacillus plantarum] - treatment with Lactobacillus plantarum L137 increased the abundance of Lactobacillus species, improved intestinal barrier integrity via upregulation of #ZO-1, as well as modulated cytokine levels. - In #Colitis mice, treatment with Lactobacillus plantarum L137 ameliorated disease-associated changes and exhibited an anti-inflammatory effect. [1.102] [#Metabolic associated fatty liver disease] [#Bile Acids] [#High Fat Diet] - high-fat diets (HFD) have been found to increase specific Lactobacillus species resistant to BAs, which may influence lipid metabolism and contribute to MAFLD development. [1.103] [#Alcohol Consumption] - the alcohol group had higher Lactobacillus and #RoseburiaReferences Notes[ ]
