Vaginally delivery {50000113} Record Keys Definition:Vaginally delivery Queue:[ ] Details Initialisation date:2019-02-24 Specification: [ ] Meta Information Type:Diet, Habit Host: Human Notes: - During life, the numbers of bifidobacteria decrease from up to 90% of the total colon microbiota in vaginally delivered breast-fed infants to <5% in the colon of adults and they decrease even more in that of elderly. - The dominant early colonizers of the normal infant gut are maternal fecal bacteria, mainly members of Bifidobacterium and Bacteroides (2)Shared Reference Notes [1.1] - Gamma aminobutyrate (#GABA), a major CNS inhibitory neurotransmitter, is produced from #Lactobacillus and is the first bacterium that is colonized with most vaginally born infants. [1.2] [#Pregnancy] [#Cesarean section] [1.3] [#Neonate] - Infant gut metabolomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. - delivery mode, breastfeeding, use and type of infant formula, and prior antibiotics significantly influenced infant microbiomes or metabolomes for at least one sampling time point. - Early infant colonizers #Streptococcus thermophilus and #Lactobacillus acidophilus transiently expanded around the time of delivery, whereas #Anaerotruncus colihominis, a species with potential immunomodulatory properties was fleetingly reduced. [1.4] [#Cesarean section] - #Bacteroides indeed disappears around week 1 of life in CS-born infants after initial colonization, whereas colonization persists in those vaginally born. [1.5] [#Human breast milk] - At 6 weeks postpartum, the composition and structure of gut microbiota of #Cesarean section-delivered (CSD) #Infants differed from those of vaginally delivered (VD) #Infants, with decreased #Bacteroides and #Escherichia-#Shigella and increased #Klebsiella, #Veillonella, and #Enterococcus. - At 6 months postpartum, these delivery mode-induced microbial shifts were restored by exclusive breastfeeding, resulting in similar gut microbial profiles between VD and CSD #Infants who were exclusively breastfed and more variable gut microbial profiles between VD and CSD #Infants who were mixed fed.References Notes (2) [1.6]
