Microbiome & Chronic Diseases

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Vaginally delivery {50000113}

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Vaginally delivery
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Diet, Habit


- During life, the numbers of bifidobacteria decrease from up to 90% of the total colon microbiota in vaginally delivered breast-fed infants to <5% in the colon of adults and they decrease even more in that of elderly.

- The dominant early colonizers of the normal infant gut are maternal fecal bacteria, mainly members of Bifidobacterium and Bacteroides (2)

Shared Reference Notes

  • [1.1
    - Gamma aminobutyrate (#GABA), a major CNS inhibitory neurotransmitter, is produced from #Lactobacillus and is the first bacterium that is colonized with most vaginally born infants.
  • [1.2] [#Pregnancy] [#Cesarean section
  • [1.3] [#Neonate
    - Infant gut metabolomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. - delivery mode, breastfeeding, use and type of infant formula, and prior antibiotics significantly influenced infant microbiomes or metabolomes for at least one sampling time point. - Early infant colonizers #Streptococcus thermophilus and #Lactobacillus acidophilus transiently expanded around the time of delivery, whereas #Anaerotruncus colihominis, a species with potential immunomodulatory properties was fleetingly reduced.
  • [1.4] [#Cesarean section
    - #Bacteroides indeed disappears around week 1 of life in CS-born infants after initial colonization, whereas colonization persists in those vaginally born.

References Notes

  • (2) [1.5