Disease ⇒ Hypercholesterolaemia {40000312} Record Keys Type:Disease Parent:[ ] Definition:Hypercholesterolaemia Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10020603 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - coprostanol-forming microbes : ismA genes > cholesterol dehydrogenases : Cholestrol > contribute to coprostanol formation: significantly lower fecal cholesterol levels and lower serum total cholesterol with effects comparable to those attributed to variations in lipid homeostasis genes. [1.2] - High levels of #Isobutyric acid could be one such biomarker for hypercholesterolemia. [1.3] [#Beta-glucan] [#Oat] - Oats could be considered a functional food because of the presence of β-glucan, a soluble fiber shown to reduce #Cholesterol - #Bile Acids can be deconjugated by certain microbiota, which inhibits their reabsorption > elevation of bile acid synthesis inliver > reducing of Blood #Cholesterol [1.4] [#CVD] [#Enterococcus faecium, #Lactobacillus paracasei] [#Cholesterol] - E. faecium strain 132 and L. paracasei strain 201 may alleviate hypercholesterolemia in rats - #Enterococcus faecium strain 132 and #Lactobacillus paracasei strain 201 reduced liver inflammation, improved the lipid profile by regulating the gene expression related to #Cholesterol metabolism and reduced fat accumulation. [1.5] - #Lactobacillus and #Bifidobacterium, which act as beneficial bacteria in the gut, contribute to the prevention of diseases such as hypercholesterolemia [1.6] [#CVD, #Hyperlipidemia] - Species from the #Oscillibacter genus were associated with decreased fecal and plasma #Cholesterol levels. - human gut #Oscillibacter isolates > conserved #Cholesterol-metabolizing capabilities, including glycosylation and dehydrogenation. - #Cholesterol metabolism is a broad property of phylogenetically diverse #Oscillibacter spp.References Notes[ ]
