Lab ⇒ Hyperuricemia {40000632} Record Keys Type:Lab Parent:[ ] Definition:Hyperuricemia Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Uric acid] [#Antibiotic Therapy] - Ablation of the microbiota in uricase-deficient mice causes severe hyperuricemia - anaerobe-targeted antibiotics increase the risk of #Gout in humans. [1.2] [#Gout] - Altered compositions of microbiota, characterized by a reduced abundance of genus #Coprococcus, were found in subjects with hyperuricemia compared with those with normouricemia. [#Alistipes indistinctus] - decreased A. indistinctus was associated with enhanced risk of hyperuricemia. [#Alistipes indistinctus] [#Uric acid] - #Hippuric acid functioned as the key microbial effector of A. indistinctus to lower UA. [#Alistipes indistinctus] [#Uric acid] - Replenishment of A. indistinctus and #Hippuric acid alleviated hyperuricemia via enhancing ABCG2-mediated intestinal UA excretion. [#Uric acid, #Urolithin A] - #Alistipes indistinctus (A. indistinctus) was found to be a keystone bacterium for maintaining optimal UA > lower UA. - levels of #Prevotella, #Dehalobacterium, #Ruminococcus, and #Lactobacillus were found to be remarkably lower in rat model of hyperuricemia. [#Uric acid] - the phenotype of elevated UA was transmissible with fecal microbial transplantation from donors with hyperuricemia. [1.3] [#Gout] - #Escherichia-#Shigella exhibited a positive association with SU levels, while #Lachnospiraceae NC2004 group and Family XIII AD3011 group were associated with a reduced HUA risk.References Notes[ ]
