Microbiome & Chronic Diseases

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Oleic acid {90000277}

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Oleic acid
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Shared Reference Notes

  • [1.1] [#Covid-19
    - #Corynebacterium accolens is a common nose inhabitant - #Corynebacterium accolens incidence was significantly decreased in the URT of patients with SARS-CoV-2 compared with uninfected controls. #Corynebacterium accolens can inhibit Streptococcus pneumoniae and Staphylococcus aureus growth, possibly through triolein hydrolysis, which releases oleic acid. - In addition to inhibiting bacterial pathogens, oleic acid is capable of inhibiting other enveloped viruses, such as herpes and influenza. - Oleoylethanolamide, an oleic acid derivative, may inhibit the release of proinflammatory cytokines induced by SARS-CoV-2, potetially reducing the risk of a patient developing a cytokine storm, which is associated with severe disease and high mortality.
  • [1.2] [#Stearic acid
    - administration of oleic and stearic acids exacerbated #Psoriasis-like symptoms:
  • [#Stearic acid] - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of #Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids.
  • [1.3] [#Alzheimer’s disease] [#Olive oil
    - A significantly decreased level of oleic acid has been observed in the brains of patients suffering from major depressive disorders and Alzheimer’s diseas
  • - #Olive oil > oleic acid (OA) content (70–80%) is responsible for its many health properties. - The best-characterized mechanism highlights OA as a natural activator of #Sirtuin 1 (SIRT1). - #Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor.

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