Oleic acid {90000277}

Shared Reference Notes

• [1.1] [#Covid-19] 
  - #Corynebacterium accolens is a common nose inhabitant - #Corynebacterium accolens incidence was significantly decreased in the URT of patients with SARS-CoV-2 compared with uninfected controls. #Corynebacterium accolens can inhibit Streptococcus pneumoniae and Staphylococcus aureus growth, possibly through triolein hydrolysis, which releases oleic acid. - In addition to inhibiting bacterial pathogens, oleic acid is capable of inhibiting other enveloped viruses, such as herpes and influenza. - Oleoylethanolamide, an oleic acid derivative, may inhibit the release of proinflammatory cytokines induced by SARS-CoV-2, potetially reducing the risk of a patient developing a cytokine storm, which is associated with severe disease and high mortality.
• [1.2] [#Stearic acid] 
  - administration of oleic and stearic acids exacerbated #Psoriasis-like symptoms:
• [#Stearic acid] - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of #Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids.
• [1.3] [#Alzheimer’s disease] [#Olive oil] 
  - A significantly decreased level of oleic acid has been observed in the brains of patients suffering from major depressive disorders and Alzheimer’s diseas
• - #Olive oil > oleic acid (OA) content (70–80%) is responsible for its many health properties. - The best-characterized mechanism highlights OA as a natural activator of #Sirtuin 1 (SIRT1). - #Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor.

References Notes