Oleic acid {90000277} Record Keys Parent:[ ] Definition:Oleic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Covid-19] - #Corynebacterium accolens is a common nose inhabitant - #Corynebacterium accolens incidence was significantly decreased in the URT of patients with SARS-CoV-2 compared with uninfected controls. #Corynebacterium accolens can inhibit Streptococcus pneumoniae and Staphylococcus aureus growth, possibly through triolein hydrolysis, which releases oleic acid. - In addition to inhibiting bacterial pathogens, oleic acid is capable of inhibiting other enveloped viruses, such as herpes and influenza. - Oleoylethanolamide, an oleic acid derivative, may inhibit the release of proinflammatory cytokines induced by SARS-CoV-2, potetially reducing the risk of a patient developing a cytokine storm, which is associated with severe disease and high mortality. [1.2] [#Stearic acid] - administration of oleic and stearic acids exacerbated #Psoriasis-like symptoms: [#Stearic acid] - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of #Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids. [1.3] [#Alzheimer’s disease] [#Olive] - A significantly decreased level of oleic acid has been observed in the brains of patients suffering from major depressive disorders and Alzheimer’s diseas - #Olive oil > oleic acid (OA) content (70–80%) is responsible for its many health properties. - The best-characterized mechanism highlights OA as a natural activator of #Sirtuin 1 (SIRT1). - #Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. [1.4] - oleic acid is beneficial for #Lactobacillus spp. [1.5] [#Obesity] [#Olive] - The major fatty acid in EVOO, oleic acid, assists in maintaining #Glucose homeostasis by activating the G protein–coupled receptors GPR-120 and GPR-40, leading to intestinal GLP-1 release and widespread ant-inflammatory effects in a variety of tissues, including liver and adipose tissue. [1.6] - #Corynebacterium accolens, a benign lipid-requiring species present in nostrils, can inhibit pneumococcal growth when supplemented with human skin surface TAGs thanks to a TAG lipase, LipS1, that hydrolyzes #Triolein into oleic acidReferences Notes[ ]
