Lab ⇒ Vaginal microbiota {40000554} Record Keys Type:Natural Med. Cond., Lab Parent:[ ] Definition:Vaginal microbiota Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] -The vaginal microbiota can be characterized in five Community State-Types (CST), representing different microbial groups. CST-I has a predominant abundance of L. crispatus, CST-II has L. gasseri, CST-III has L. iners, and CST-V has L. jensenii. CST-IV, on the other hand, has a reduction of Lactobacillus spp. and a higher abundance of anaerobic bacteria such as Prevotella, Atopobium, Sneathia, and Gardnerella, which have been associated with bacterial vaginosis [1.2] [#Vulvovaginal candidiasis] [#Candida albicans] - #Lactobacillus spp. produces lactic and other organic acids that contribute to the low pH within the vaginal cavity. - Low pH (< 4.5) inhibits C. albicans yeast-to-hypha transition. [1.3] - increased diversity of vaginal microbiota and reduced abundance of #Lactobacillus spp. contribute to #HPV acquisition, persistence, and development of #Cervical cancer. [1.4] [#Bacterial vaginosis, #Normal Vaginal condition] - Type 3 CST is dominated by #Lactobacillus iners, but it can coexist with both healthy and disruptive bacteria. - If found with disruptive bacteria, it can cause symptoms like itching and abnormal discharge. - When found with protective lactobacilli, it’s neutral or even protective. - Type 3 has two subtypes: 3-A and 3-B. - The main difference is that 3-A has more L. iners. [1.5] [#Cesarean section, #Vaginal Microbiome Transfer] - Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related microbiome disturbancesReferences Notes[ ]
