Desulfovibrionaceae ⇒ Desulfovibrio {10000269}

Shared Reference Notes

• [1.1] [#Alzheimer’s disease] 
  - Decrease in #Bacteroidetes and #Alloprevotella and increase in #Proteobacteria, #Verrucomicrobia, #Akkermansia, and Desulfovibrio > improve short-term memory ability and cognitive level of AD mice
• [1.2] 
  - Desulfovibrio is a #Sulfur-reducing bacteria (SRB) that can degrade mucins, SCFAs, and amino acids (glutamate, alanine) in the human colon, and may help to maintain the integrity of the gut epithelium.
• [1.3] [#High-protein diet] 
  - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, #Prevotella, #Ruminococcus, #Roseburia, and #Faecalibacterium.
• [1.4] [#Bacteroides-Prevotella group, #Clostridium III] 
  - in neurodegenerative disease > #Streptococcus, #Shigella, Desulfovibrio, Christensenelia, and #Akkermansia muciniphila have the #Putrescine III synthesis pathway and belong to the elevated microbes group.
• - in neurodegenerative disease > The microbes with elevated populations, like #Bilophila, Butryicicoccus, #Alistipes, #Enterococcus, #Lactobacillus, #Streptococcus, #Shigella, and Desulfovibrio, have the metabolic capability to produce #Putrescine majorly by the #Putrescine III biosynthesis pathway.
• - In neurodegenerative diseases > #Histamine and other important #Neurotransmitters were synthesized in reduced amounts by the microbes with an elevated population in the diseased state. - Most of the microbes, except Desulfovibrio, #Lactobacillus, and #Streptococcus, showed no annotation in their #Genome to synthesize #Histamine.
• - Desulfovibrio and #Shigella showed a high score for the formation of #Butyrate, which is found in an elevated amount in neurodegenerative diseases.
• [1.5] 
  - Various Desulfovibrio strains have been shown to adhere to the epithelial cell surface, invade into the cell cytoplasm, and replicate within the cells
• [#Alpha-synuclein, #Hydrogen sulfide] - gut inflammation reduces the capacity of H2S inactivation system, which allows Desulfovibrio -produced H2S to accumulate and enhance alpha-syn aggregation.
• [#Alpha-synuclein, #Lipopolysaccharide] - lipopolysaccharides which are known to be present in the outer membrane of Gram-negative bacteria, including Desulfovibrio bacteria, may be an additional virulence factor. Lipopolysaccharides have been shown to modulate alpha-syn aggregation
• [#Parkinson’s Disease] - Desulfovibrio bacteria isolated from the fecal samples of PD patients were more competent to induce alpha-syn aggregation than the DSV bacteria isolated from the samples of healthy individuals. - patient Desulfovibrio strains significantly increased the fatality rate of the nematodes.
• [#Parkinson’s Disease] [#Escherichia coli] - Desulfovibrio bacteria from PD patients harbored significantly more (P<0.001, Kruskal-Wallis and Mann-Whitney U test) and larger alpha-syn aggregates (P<0.001) than worms fed Desulfovibrio bacteria from healthy individuals or worms fed E. coli strains.
• [#Parkinson’s Disease] [#Escherichia coli] [#Alpha-synuclein] - Desulfovibrio strains, particularly those from PD patients, were more competent than #Curli-producing E. coli in stimulating the accumulation of larger and more abundant alpha-syn aggregates.
• [#Parkinson’s Disease] [#Hydrogen sulfide] - increased amounts of H2S producing bacteria such as Desulfovibrio bacteria play a role in the pathogenesis of PD
• - #Sulfate-reducing bacteria (SRB), to which group Desulfovibrio bacteria belongs, have been shown to induce apoptosis of human colonic epithelial cells when the SRB enrichments originated from patients suffering from #Ulcerative Colitis
• [1.6] [#Escherichia coli, #Helicobacter pylori, #Shigella flexneri] 
  - Notable genera in the #Proteobacteria are #Escherichia, #Salmonella, #Shigella, Desulfovibrio, and #Helicobacter. Included in the phyla is the #Enterobacteriaceae family, which contains several enteropathogenic bacteria, including #Shigella flexneri, #Salmonella typhi, and #Escherichia coli. Other enteric pathogens in this phylum are #Vibrio cholerae and #Helicobacter pylori.
• [1.7] 
  - A similar correlation with high absolute tissue eosinophil counts and percentages of tissue eosinophils is also seen in the abundance of the genera #Parabacteroides, #Bifidobacterium, #Bacteroides, #Microbacterium, #Faecalibacterium, #Lactococcus, Desulfovibrio, and #Ruminococcus.
• [1.8] 
  - #Collinsella is a hydrogen-reducing bacteria that could cross-feed with Desulfovibrio.
• [#Alpha-synuclein] - Desulfovibrio is a #Hydrogen sulfide (H2S) and #Lipopolysaccharide (LPS)-producing bacteria. - LPS-treated mice would present intestinal hyperpermeability and a higher level of pathological α-syn accumulation
• [#Parkinson’s Disease] - the genera #Akkermansia and #Oscillospiraceae UCG-005, which have been identified as prodromal PD RBD-enriched - bacteria (e.g., #Collinsella and Desulfovibrio) which were potentially related to PD pathogenesis were already increased in prodromal PD RBD patient
• [#Parkinson’s Disease] - In prodromal PD patients, the overall microbiota composition shifted closely to early PD, with depletion of #Butyrate-producing bacteria, and overabundance of pro-inflammatory #Collinsella, Desulfovibrio, and #Oscillospiraceae UCG-005.
• [1.9] 
  - protective role against #Female infertility, > #Ruminococcus, Desulfovibrio. #Bifidobacteriales, #Bifidobacterium, #Actinobacteria, #Ruminococcaceae NK4A214, #Bifidobacteriaceae, #Actinobacteria, #Holdemania.
• [#Systemic lupus erythematosus] - SLE > increased abundance of genera #Candidatus saccharimonas, Desulfovibrio, #Odoribacter and #Roseburia in mice treated with HCMVpp65 peptide is significantly correlated with lupus-like effects including enhanced levels of creatinine, proteinuria, glomerular damage and anti-dsDNA antibodies.
• [1.11] 
  - #Prevotella and Desulfovibrio, is overexpressed with four enzymes—hydroxymethylpyridine kinase, phosphomethylpyridine kinase, thiamine-phosphate pyrophosphorylase, and thiamine-monophosphate kinase—crucial for #Thiamin biosynthesis
• [1.12] [#Autism] 
  - The increased abundance of #Clostridia and Desulfovibrio and #Bacteroidetes/#Firmicutes ratio were related to the severity of ASD and gastrointestinal symptoms.
• [1.13] 
  - #Sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, Desulfovibrio, #Escherichia coli, #Fusobacterium, #Klebsiella, #Lactobacillus, #Morganella, #Odoribacter, and #Proteus.
• [1.14] [#Inflamatory bowel disease] [#Escherichia coli] 
  - #Colectomy > there was a significant increase in the expansion of E.coli in individuals who underwent surgery and, in particular, samples from IBD patients who underwent #Colectomy had the highest abundance of E.coli. - At 6 months, endoscopic recurrence was associated with elevated #Proteus genera and at 18 months with reduced #Faecalibacterium, Desulfovibrio and #Bilophila abundance. At 18 months severe endoscopic recurrence was associated with increase in #Proteobacteria.
• [1.15] [#Treponema medium] [#Hydrogen sulfide] 
  - Complete utilization of #Taurine as electron acceptor in modified Desulfovibrio liquid medium with electron donors #Lactate and #Pyruvate in excess resulted in production of nearly quantitative amounts of H2S and excess #Acetate
• [1.16] [#Carbohydrate diet] 
  - On a #Fructose-rich diet, mice lost beneficial bacteria such as #Prevotella, #Muribaculum, and #Bifidobacterium - These #Fructose-rich diet mice also showed an enrichment of Desulfovibrio, #Collinsella, #Olsenella, and #Bacteroides as well as increased frequency of immune cells with pro-inflammatory characteristics
• [1.17] 
  - Desulfovibrio, #Desulfobacter, #Desulfomonas, #Desulfobulbus, and #Desulfotomaculum are the 5 most common intestinal #Sulfate-reducing bacteria (SRB) genera.
• [1.18] [#Clostridium asparagiforme, #Clostridium citroniae, #Clostridium hathewayi, #Clostridium sporogenes] [#TMA, #TMAO] 
  - #Clostridium sp (C asparagiforme, C citroniae, C hathewayi, and C sporogenes), Desulfovibrio, and #Enterobacteriaceae (#Escherichia coli and #Acinetobacter sp), can respond to a diet rich in #Choline, an essential nutrient for omnivores, and convert it to trimethylamine, which is then metabolised in the liver to trimethylamine N-oxide, a microbiome derived proatherogenic metabolite.
• [1.19] [#Alzheimer’s disease] 
  - the percentage of DCX-positive neuroblasts inversely correlated with parabiont genera Desulfovibrio and #Dialister, and the percentage of Map2-positive cells inversely correlated with genera Desulfovibrio, #Dialister and #Eisenbergiella.
• [#Alzheimer’s disease] [#Fecal Microbiota Transplantation] - one of the genera that was increased at Day 59 post Alzheimer’s-FMT compared to Day 10 was Desulfovibrio, a genus that was also significantly enriched in Alzheimer’s participants.
• [#Alzheimer’s disease] [#Short Chain Fatty Acid] - The parabiont Desulfovibrio has also been found to be enriched in other Alzheimer’s cohorts and is associated with reduced caecal levels of SCFAs and with inflammation in mice.
• - genus #Eisenbergiella increases with severity of #Cognitive impairment and that genus Desulfovibrio was negatively correlated with MMSE scores.
• [#Exercise training, #Western-style diet] - Desulfovibrio has been found to be increased by a Western style diet and by a #High Fat Diet but decreased by endurance exercise
• - #Indole is an inter-kingdom signal in gut epithelial cells, reinforcing the host cell-barrier assets - It is derived from #Tryptophan, produced by several microbes (i.e., #Bacteroides, #Clostridium, Desulfovibrio) colonizing the human GI tract - It is a critical precursor of physiologically important molecules, such as #Serotonin and #Melatonin
• [1.21] [#Kidney stone] 
  - Desulfovibrio enriched in Nephrolithiasis > The intestinal #oxalate-#Sulfate antiporter (SAT-1) has been implicated in human CaOx nephrolithiasis; as #Sulfate-reducing bacteria, Desulfovibrio spp. may reduce the bioavailability of the influx substrate leading to greater plasma #oxalate levels, as is observed in cohorts with #Autism.
• [1.22] 
  - In chronic #Intermittent Hypoxia (CIH) mice, beneficial genera like #Clostridium, #Akkermansia, and #Bacteroides reduced in presence while pathogenic genera like Desulfovibrio increased.
• [#Intermittent Hypoxia] - IH mice exhibited increased levels of Desulfovibrio, a bacterium that adversely impacts the intestinal barrier, contributing to the disruption of the intestinal barrier.
• [1.23] 
  - the predominant anti-inflammatory bacteria in the #Vitamin A Normal group are #Akkermansia and #Verrucomicrobiales, while the anti-inflammatory bacterial communities in the VAS group belong to the genus Desulfovibrio.
• [#Colitis] - Desulfovibrio are #Sulfate-reducing bacteria have the ability to reduce #Sulfate to #Hydrogen sulfide, which, when accumulated, can lead to damage to the intestinal epithelium, causing chronic inflammation and disrupting the balance between cellular proliferation and apoptosis
• [1.24] 
  - Desulfovibrio and #Catenabacterium may serve as protective factors in the onset of Drug-induced #Obesity.

References Notes