Ruminococcaceae ⇒ Faecalibacterium {10000187}

Shared Reference Notes

• [1.1] 
  - Reduced abundance of Faecalibacterium was found to be predictive of RA and this bacterium was found to be significantly positively correlated with a number of metabolites including the vitamin B metabolites riboflavin, nicotinate and pantothenate; nucleotides adenine, guanine and uracil; and the SCFA butyrate. - As a butyrate producer, Faecalibacterium is generally considered beneficial
• [1.2] [#Autism] 
  - Increase in Faecalibacterium in ASD children is responsible for the progression of inflammatory processes, with increased levels of type I interferon, and the alteration of the intestinal barrier.
• [1.3] [#Alzheimer’s disease] 
  - Increasing the relative abundance of #Bacteroides and Faecalibacterium may improve cognitive levels
• [1.4] [#Obesity, #Diabetes Type 2] [#Gender, #Resistant starch] 
  - gut microbiota, especially Faecalibacterium, Predict postprandial glucose response (PPGR) after eating potatoes.
• [1.5] [#Chronic fatigue syndrome, #Inflamatory bowel disease, #Multiple Sclerosis] 
  - MC/CFS > a reduction of Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , #Cancer-related fatigue (compared to #Cancer patients with low fatigue) and other autoimmune diseases such as MS and #Diabetes Type 1 .
• [#Chronic fatigue syndrome] - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes - in particular an increase of #Alistipes and a decrease of butyrate-producer Faecalibacterium were considered as top biomarkers with potential diagnostic value - abundance of #Bifidobacterium and Faecalibacterium to be reduced in the affected twin compared to the non-affected one. - Decreases in Faecalibacterium and increases in #Coprobacillus were found. - Gut abundances of #Coprobacillus, of #Eggerthella and #Blautia were best able to distinguish patients from controls. - distinct microbial pattern with decreased anti-inflammatory #Firmicutes
• [1.6] [#Infectious diarrhea] 
  - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, #Prevotella, Faecalibacterium, #Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
• [1.7] [#Parkinson’s Disease] 
  - #Prevotellaceae (Prevotella), #Ruminococcaceae (Faecalibacterium), #Lachnospiraceae (#Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
• [1.8] 
  - Decreases in SCFA-producing bacteria, specifically belonging to #Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical #Sleep Deprivation and 3-day continuous #Sleep Deprivation. - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption. - #Sleep Deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of #Lactobacillus plantarum.
• - patients with psoriasis report a relative reduction in intestinal abundance of #Akkermansia, #Ruminococcus, or Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
• [1.9] 
  -The antibacterial and antitumor defensin (HBD1) showed decreased levels in #Prostate cancer patients, while others (HBD2 and 3) were considerably increased. - Abundance of #Staphylococcus, #Corynebacterium and #Oxyphotobacteria genera was significantly higher, the abundance of Faecalibacterium and #Bacteroides genera were significantly lower in prostate tumor samples compared to non-tumor samples. - #Bacteroides, Parabacteroides and Faecalibacterium abundance gradually decreased with the combined increase in HBD2 and HBD3. - Higher #Corynebacterium and #Staphylococcus abundances were measured together with higher HBD2 and HBD3 urinary levels.
• [#Asthma] [#Children] - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium, Faecalibacterium, #Ruminococcus, and #Roseburia) are associated with childhood respiratory diseases.
• [1.11] 
  - the intestines and colon are enriched with anaerobes including the #Clostridium and Faecalibacterium genera.
• [1.12] [#Clostridium difficile associated disease] 
  - #Vancomycin is used for C. difficile (CDI) which is associated with decrease in number of gut microbes like #Bacteroidetes, #Fuminococcus, and Faecalibacterium and increases in #Proteobacteria species.
• [1.13] 
  - At the genus level, #Prevotella and #Bacteroides were significantly enriched in the #Meditation group. - Two beneficial bacterial genera (#Megamonas and Faecalibacterium) were significantly enriched in the #Meditation group. - Several pathways—including glycan biosynthesis, metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the #Meditation group. - Plasma levels of clinical risk factors were significantly decreased in the #Meditation group, including total #Cholesterol and apolipoprotein B.
• [1.14] 
  - Butyrylated high-amylose maize resistant starch decreased red meat-derived pro-mutagenic adduct O6-methyl-2-deoxyguanosine and related CRC risk. - Certain #Butyrate-producing bacteria such as #Clostridium, #Ruminococcus, Faecalibacterium spp., #Eubacterium spp., and #Roseburia, were found to decrease in relative frequency in CRC patients. - #Butyrate inhibited the growth of CRC cells and induced their apoptosis in vitro at pharmacologically high concentrations.
• [1.15] [#Diabetes Type 2] 
  - A reduction in the #Lachnospira, #Roseburia, Faecalibacterium and #Coprococcus genera in the T2D group. - These genera were #Butyrate producers. - The decrease of these genera favored #Obesity and the development of diseases.
• [1.16] [#Chronic fatigue syndrome] [#γ-butyrobetaine] 
  - Decreased γ-butyrobetaine correlated with increased Faecalibacterium.
• [1.17] [#Parkinson’s Disease] 
  - PD > increased relative abundance of family Enterobacteriaceae, genera #Akkermansia, #Lactobacillus, #Bifidobacterium. - PD > decreased relative abundance of family #Lachnospiraceae, Faecalibacterium
• [1.18] [#Bipolar disorder, #Major depressive disorder] 
  - MDD and BD had more commonalities, including higher #Enterococcus, #Flavonifractor, and #Streptococcus, and lower Faecalibacterium and #Ruminococcus.
• [#Bipolar disorder] - BD patients with a depressive episode > increased levels of #Coriobacteria and #Actinobacteria together with decreased #Ruminococcaceae and Faecalibacterium.
• [1.19] [#High-protein diet] 
  - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, #Prevotella, #Ruminococcus, #Roseburia, and Faecalibacterium.
• - Higher caffeine and #Coffee intake was related to higher alpha diversity higher relative abundance of Faecalibacterium and #Alistipes, and lower relative abundance of #Erysipelatoclostridium. - After adjustment of vitamin B2 in multivariate analysis, the significant inverse association between #Erysipelatoclostridium count and caffeine intake remained statistically significant.
• [1.21] [#Aging] 
  - the loss of #Lactobacillus and Faecalibacterium, as well as the abundance of #Oscillibacter and #Alistipes genera along with the #Eubacteriaceae family is linked to #Frailty in elderly people.
• [1.22] [#Soybean] 
  - high intake of milk and soy beverages was associated with a higher abundance of beneficial faecal microbes including Faecalibacterium, #Bifidobacterium, and #Parabacteroides. - consumption of fermented soy milk was associated with increased abundance of #Bifidobacterium, bifidobacteria and/or Lactobacillus compared to unfermented soy milk.
• [1.23] [#Faecalibacterium prausnitzii] [#Physical activity] 
  - in males with normal BMI, a stronger grip strength was associated with a higher relative abundance of Faecalibacterium and F. prausnitzii compared with lower grip strength.
• [1.24] [#CVD, #Obesity] [#Inulin-Type Fructans] 
  - Addition of ITF to the #Plant-based diet reduced microbial diversity and selectively increased #Bifidobacterium and Faecalibacterium. -- The change in the latter was significantly associated with higher values of insulin and HOMA-IR and lower HDL #Cholesterol. - The LDL:HDL ratio and the concentrations of IL-10, MCP-1 and TNFα were significantly elevated in the ITF-subgroup.
• [1.25] [#Whole grains] 
  - Several #Butyrate-producers (e.g., Faecalibacterium, #Roseburia, Butyriciococcus) were inversely associated with colonic transit time and/or faecal pH, while the mucin-degraders #Akkermansia and #Ruminococcaceae showed the opposite association.
• [1.26] [#Athletes] 
  - Faecalibacterium, #Sutterella, #Clostridium, #Haemophilus, and #Eisenbergiella were the most abundant in bodybuilders, while #Bifidobacterium and #Parasutterella were the least abundant.
• [#Short Chain Fatty Acid] [#Exercise training] - A six-week moderate to intense aerobic exercise (30–60 min) program can induce a shift in the SCFA-producing Faecalibacterium and #Lachnospira spp. and genetic machinery (BCoATe) substantially in lean versus obese participants.
• [1.27] [#Acute lymphoblastic leukemia] 
  - #Roseburia, #Dialister, #Prevotella, Faecalibacterium and #Anaerostipes showed reduced relative abundance in #Children with ALL at the time of diagnosis
• - delayed maturation of the gut microbiome (characterized by reduced relative abundance of the genera #Roseburia, #Dialister, #Prevotella, Faecalibacterium and #Blautia and increased abundance of #Enterococcus), as well as reduced stool levels of #Butyrate by the age of 12 months, is associated with aberrant immune responses and an increased risk of #Asthma diagnosis by the age of 5 years
• [#Aging] - #Infants with older #Siblings exhibit increased gut microbiome α-diversity, faster gut microbiome maturation and earlier colonization with Faecalibacterium species, which are known to increase the Treg/TH17 cell ratio via inhibition of HDACs and to ameliorate gut inflammation.
• [#Aging] - A lack of older #Siblings is associated with reduced gut microbiome α-diversity and reduced relative abundance of Faecalibacterium as well as delayed maturation of the gut microbiome by the age of 12 months.
• [1.28] [#Bacteroides-Prevotella group] 
  - only Faecalibacterium, but not #Blautia, #Anaerostipes, or #Megamonas, was significantly lower in the #Hypertension group
• [#Lipopolysaccharide, #Short Chain Fatty Acid] - #Hypertension groups > low gut microbial diversity and some distinctive taxa, depleted SCFA-producing bacteria, such as Ruminococcacea and Faecalibacterium, and enriched LPS-producing gram-negative bacteria, such as #Bacteroidales, #Negativiticus, and #Megamonas,
• - Faecalibacterium is the most potent #Butyrate-producing bacteria and the biomarker most closely associated with #Hypertension prevention.
• [1.29] [#Irritable bowel syndrome] 
  - IBS patients have increased levels of the bacterial families #Enterobacteriaceae, #Lactobacillaceae, and #Bacteroidales, whereas #Bifidobacterium, Faecalibacterium, and #Clostridiales were decreased compared with healthy controls.
• [#Irritable bowel syndrome] - IBS was typified by enhanced quantities of #Firmicutes and specifically in #Ruminococcus, #Clostridium, and #Dorea, along with a distinct decrease of beneficial microbes, such as #Bifidobacterium and Faecalibacterium spp
• - #Blautia, Faecalibacterium, and #Dorea levels were consistently more abundant in 8-year-olds with #Allergy than in #Children without #Allergy. - Faecalibacterium abundance was correlated with IL-10 and FOXP3 mRNA levels.
• - #Bacteroides and Faecalibacterium had relatively high prevalences and were more abundant in #Children with severe #Asthma.
• [#Infantile eczema] [#Faecalibacterium prausnitzii] - Faecalibacterium is significantly increased in the microbiota of patients with #Atopic Dermatitis and eczema, and this genus represents only a single known species, F prausnitzii.
• - A similar correlation with high absolute tissue eosinophil counts and percentages of tissue eosinophils is also seen in the abundance of the genera #Parabacteroides, #Bifidobacterium, #Bacteroides, #Microbacterium, Faecalibacterium, #Lactococcus, #Desulfovibrio, and #Ruminococcus.
• [#Eosinophilic chronic rhinosinusitis] - nasal dysbiosis in eCRSwNP was defined by increased relative abundances of #Sphingomonas, #Moraxellaceae, #Bacteroides, #Bifidobacterium, #Ruminococcus, and Faecalibacterium, as well as by decreased abundances of #Ralstonia, #Propionibacterium, and Propionibacter.
• [1.31] [#Obesity] [#Faecalibacterium prausnitzii] 
  - Abundance of Faecalibacterium genus members (i.e., F. prausnitzii) is greater in both women and men with higher skeletal muscle mass. - increases in both lean mass and Faecalibacterium relative abundance are observed in normal weight subjects after #Exercise training.
• [1.32] [#Parkinson’s Disease] 
  - consistent reduction in preQ0 biosynthesis at prodromal PD and early α-synucleinopathy. - PreQ0 is a key intermediate of the biosynthesis of 7-#Deazapurine nucleoside. - the abundance of preQ0 biosynthesis seems strongly co-occurring with genus Faecalibacterium, a butyrate-producing bacteria and an indicator of PD progression
• [1.33] [#Bipolar disorder] 
  - negative association between Faecalibacterium abundance and #Depression severity in depressive and BD patients
• [#Bipolar disorder] - low abundance of Faecalibacterium, #Pseudomonas and #Fusobacterium in depressed BD patients may have implications for the neurobiology of BD
• - abundance of Faecalibacterium, #Pseudomonas and #Fusobacterium was negatively correlated with the severity of #Depression.
• - Faecalibacterium was found to produce a protein which was involved in anti-inflammatory activities
• - abundance of #Enterobacteriaceae and #Alistipes was increased, and Faecalibacterium abundance was decreased in patients with #Major depressive disorder
• [1.34] 
  - Faecalibacterium causally increased the possibility of #Female infertility.
• [1.35] [#Postmenopausal] 
  - Gut #Bacteria that possess β-glucuronidase and/or β-galactosidase activity can metabolize #Estrogen including #Bifidobacterium, Faecalibacterium, #Lactobacillus, #Veillonella
• [1.36] [#Sjögren syndrome ] 
  - Sjogren’s syndrome > an increase in #Bacteroidetes, an opportunistic commensal, and a decrease in #Firmicutes and Faecalibacterium > decreased Treg cells - the degree of dysbiosis was partly correlated with the severity of ocular surface disease.
• [1.37] [#Systemic lupus erythematosus] 
  - SLE patients displayed higher serum levels of #IL-2 and #IL-6. - The abundance of #Roseburia and Faecalibacterium was inversely correlated with #IL-6, the abundance of #Roseburia had a negative correlation with #IL-2, and the abundance of #Bacteroides had a positive correlation with #IL-2.
• [1.38] [#Ankylosing spondylitis, #Spondyloarthritis] 
  - Patients with SpA showed an enrichment of #Collinsella, and several Lachnospiraceae ASVs - HLA-B27+ individuals displayed enriched Faecalibacterium.
• [1.39] 
  - 60 bacterial genera from human gut microbiota (#Bacteroides, #Bifidobacterium, #Escherichia, Faecalibacterium, and #Lactobacillus,) > encode β-glucuronidase and/or β-galactosidase > impacting endogenous #Estrogen metabolism
• [#Parkinson’s Disease] [#Short Chain Fatty Acid] - Decreases of short-chain fatty acid-producing genera, #Fusicatenibacter, Faecalibacterium, and #Blautia, as well as an increase of mucin-degrading genus #Akkermansia, predicted accelerated disease progression.
• [1.41] [#Short Chain Fatty Acid] 
  - increased abundance of gut ##Ruminococcus and ##Alistipes in castration-resistant #Prostate cancer (CRPC) patients along with ##Bacteroidales, ##Rikenellaceae, #Faecalibacterium,the so called SCFAs-producing microbiotas.
• [1.42] [#Clostridiales XIV, #Clostridium cluster IV] 
  - #Walnut consumption at 42 g/day, increased #Butyrate-producing #Clostridium clusters XIV and IV including, Faecalibacterium, #Roseburia, while lowering the relative abundance of #Ruminococcus, #Dorea, Oscilllo, #Bifidobacteria.
• [1.43] 
  - patients with #Celiac Disease showed the abundance of #Streptococcus, #Lactobacillus, #Veillonella, and #Allisonella species, while the abundance of #Ruminococcus, Faecalibacterium, #Blautia, #Gemmiger, and #Anaerostipes was decreased.
• [1.44] [#Ulcerative Colitis] 
  - contrary to earlier reports, no significant loss of Faecalibacterium genera was observed in UC patients, there was even a slight increase in the abundance of Faecalibacterium in UC patients.
• [1.45] [#Gastric bypass surgery] 
  - Roux-en-Y gastric bypass (RYGB) resulted in clear alteration in composition of gut fungal and bacterial microbiota. - Before surgery, patients had higher levels of #Firmicutes and #Actinobacteria and lower levels of #Verrucomicrobia - Faecalibacterium and #Bifidobacterium showed a decrease after surgery and aerotolerant #Streptococcus was increased postoperatively. - The relative abundance of #Proteobacteria was increased after surgery. - Changes in fungal microbiota composition included decreases in #Candida and #Saccharomyces and increases in #Pichia. - levels of #Verrucomicrobia and #Proteobacteria increased after the surgery procedure - Bifidobacteriaceae abundance decreased, whereas Streptococcaceae and Enterobacteriaceae increased after surgery. - RYGB led to increased #Firmicutes and #Actinobacteria phyla but decreased #Bacteroidetes phylum
• [#Inflamatory bowel disease] [#Escherichia coli] - #Colectomy > there was a significant increase in the expansion of E.coli in individuals who underwent surgery and, in particular, samples from IBD patients who underwent #Colectomy had the highest abundance of E.coli. - At 6 months, endoscopic recurrence was associated with elevated #Proteus genera and at 18 months with reduced Faecalibacterium, #Desulfovibrio and #Bilophila abundance. At 18 months severe endoscopic recurrence was associated with increase in #Proteobacteria.
• [1.46] [#Parkinson’s Disease] [#Roseomonas mucosa] [#Short Chain Fatty Acid] 
  - #Constipation severity is significantly correlated with the decrease of #Blautia and Faecalibacterium, short chain fatty acids (SCFAs)-producing taxa that can exert positive effects on the intestinal mucosa and which are decreased in PD.
• [#Parkinson’s Disease] - #Prevotellaceae, #Lachnospiraceae, and Faecalibacterium were decreased significantly in patients with PD compared to healthy controls, while #Ruminococcaceae, #Bifidobacteriaceae, #Christensenellaceae, and #Verrucomicrobiaceae were enriched in patients with PD
• [1.47] [#Multiple Sclerosis] 
  - Individuals with relapsing-remitting MS have an abundance of #Mycoplasma, #Pseudomonas, Faecalibacterium, #Haemophilus, #Anaerostipes, #Blautia, and #Dorea, while #Bacteroides, #Prevotella, #Parabacteroides, and #Adlercreutzia are relatively less common.
• [1.48] [#Parkinson’s Disease] 
  - #Lactobacillus and #Bifidobacterium genus were most abundant in PD patients. #Prevotella VZCB and other Faecalibacterium were most abundant in controls.
• [1.49] [#Osteoporosis] 
  - higher abundances of #Lachnospiraceae NK4A136 group, and Faecalibacterium were associated with greater tibia cortical vBMD
• - SUA levels and #Gout simultaneously affect the abundance of the genus Faecalibacterium and #Prevotella. - #Gout patients had lower levels of the genus Faecalibacterium compared to healthy individuals. - negative association between SUA levels and Faecalibacterium abundance. - SUA levels are a risk factor for the increased abundance of genus Prevotella9
• [1.51] [#Butanoic acid, #Short Chain Fatty Acid] 
  - SCFAs, particularly butanoic and #Acetic acid, can be produced by Faecalibacterium, #Roseburia, #Sutterella, and #Prevotella
• [1.52] [#mRNA vaccine] 
  - Certain #Butyrate producers, such as #Lachnospira, #Catenibacterium, and Faecalibacterium, were enriched in individuals with higher immunogenic responses to the BNT162b2 vaccine
• [#Covid-19] [#mRNA vaccine] - #Bifidobacterium and Faecalibacterium showed significant association with high spike IgG titers, irrespective of other factors - Enrichment of #Bifidobacterium was correlated with CD4+ T-cell responses and higher antibody titers to parenteral and oral vaccinations.
• [1.53] [#Bacteroides-Prevotella group, #Ruminococcus gauvreauii] 
  - marked reduction in #Butyrate-producing bacterial genera, such as #Coprococcus, and #Subdoligranulum, in both the ileum and colon; Faecalibacterium in colon; and [#Ruminococcus] gauvreauii group in fecal samples from People living with HIV (PLWH)
• - #Erysipelotrichaceae UCG-003, #Coprococcus, Faecalibacterium, and #Subdoligranulum, significantly lower in PLWH and were associated with slower rates of biological #Aging.
• [1.54] [#Collagen-induced arthritis , #Rheumatoid Arthritis, #Spondyloarthritis] [#Lachnospiraceae bacterium] 
  - in CIA (such as Lachnospiraciae and Lactobacillaeae), RA (#Lachnospiraceae bacterium, #Lactobacillus spp., Faecalibacterium), and SpA (#Ruminococcaceae, #Rikenellaceae, #Porphyromonadaceae, #Bacteroidaceae, #Lachnospiraceae) are either predicted or known to produce #Indole
• [1.55] 
  - Faecalibacterium and #Agathobacter > can produce #Butyrate by cross-feeding with #Bifidobacterium
• - The #Cranberry extract supplementation increased the abundance of Faecalibacterium and #Agathobacter in subjects from enterotype 1 (#Prevotella enterotype), concomitant to a decrease of #Prevotella.
• [1.56] [#Diabetes Type 2] 
  - Metabolites associated with the identified fiber-related bacteria (Both #Butyrivibrio and Faecalibacterium) , including several microbial metabolites (eg, #Indolepropionate and #3-phenylpropionate) inversely associated with the risk of T2D.
• [#Diabetes Type 2] [#High fibre diet] - multiple bacterial genera, species, and related enzymes associated with fiber intake. Several bacteria (eg, #Butyrivibrio, Faecalibacterium) and enzymes involved in fiber degradation (eg, xylanase EC3.2.1.156) were positively associated with fiber intake, inversely associated with prevalent T2D, and favorably associated with T2D-related metabolic traits.
• [1.57] [#Autism] 
  - #Citrate levels were higher in future ASD, consistent with increased #Succinate and #Citrate in urine, while #Uridine levels in stool positively correlated with Faecalibacterium.
• [1.58] [#Schizophrenia] [#Ruminococcus] 
  - #Shigella and #Collinsella were more abundant in SCZ patients, and Faecalibacterium, #Coprococcus, #Prevotella, #Haemophilus, Ruminococcaceae_Ruminococcus, #Bacteroides, and #Oscillospira are significantly abundant in HC
• [1.59] [#Diabetes Type 2] 
  - #Blautia, Faecalibacterium, #Bifidobacterium, #Clostridium, #Anaerostipes, #Mediterraneibacter, and #Butyricicoccus abundances were relatively higher in healthy fecal samples than in prediabetic fecal samples.
• [#Short Chain Fatty Acid] [#Diet Inflammatory Index] - microbiome members that were depleted in individuals reporting high DII scores included known producers of anti-inflammatory SCFAs such as Faecalibacterium
• [1.61] [#Metabolic Dysfunction-associated Steatohepatitis] 
  - patients with lean NASH had a threefold reduction in the abundance of Faecalibacterium and #Ruminococcus

References Notes