Microbiome & Chronic Diseases

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Faecalibacterium ⇒ Ruminococcaceae {10000187}

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Initialisation date:


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Enzyme:[  ]
Mucin-degrading, Anti-inflammatory, Fatigue-inducing


- Short chain fatty acid producer

References Notes

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Shared Reference Notes

  • [1.100
    - Reduced abundance of Faecalibacterium was found to be predictive of RA and this bacterium was found to be significantly positively correlated with a number of metabolites including the vitamin B metabolites riboflavin, nicotinate and pantothenate; nucleotides adenine, guanine and uracil; and the SCFA butyrate.
    - As a butyrate producer, Faecalibacterium is generally considered beneficial
  • [1.101
    - Increase in Faecalibacterium in ASD children is responsible for the progression of inflammatory processes, with increased levels of type I interferon, and the alteration of the intestinal barrier.
  • [1.102
    - Increasing the relative abundance of Bacteroides and Faecalibacterium may improve cognitive levels
  • [1.103
    - gut microbiota, especially Faecalibacterium, Predict postprandial glucose response (PPGR) after eating potatoes.
  • [1.34
    - MC/CFS > a reduction of Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , cancer-related fatigue (compared to cancer patients with low fatigue) and other autoimmune diseases such as MS and diabetes type 1 .
  • - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased Lactonifactor and Alistipes
    - in particular an increase of Alistipes and a decrease of butyrate-producer Faecalibacterium were considered as top biomarkers with potential diagnostic value
    - abundance of Bifidobacterium and Faecalibacterium to be reduced in the affected twin compared to the non-affected one.
    - Decreases in Faecalibacterium and increases in Coprobacillus were found.
    - Gut abundances of Coprobacillus, of Eggerthella and Blautia were best able to distinguish patients from controls.
    - Decreases in Faecalibacterium and increases in Coprobacillus were found.
    - distinct microbial pattern with decreased anti-inflammatory Firmicutes
  • [1.62
    - A drastic disappearance of obligate anaerobic gut commensals (Blautia, Prevotella, Faecalibacterium, Lachnospiraceae, Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as short chain fatty acid (SCFAs)
  • [1.77
    - Prevotellaceae (Prevotella), Ruminococcaceae (Faecalibacterium), Lachnospiraceae (Blautia, Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
  • [1.99
    - patients with psoriasis report a relative reduction in intestinal abundance of Akkermansia, Ruminococcus, or Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
  • - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation.
    - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
    - sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum.

Common References