Disease ⇒ Cognitive impairment {40000159}
Type: | Disease |
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Definition: | Cognitive impairment |
Parent: | [ ] |
Initialisation date: | 2021-09-09 |
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Other Terms: | [ ] |
MedDra ID: | [ ] |
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MedDra Level: | [ ] |
ICD: | [ ] |
Category: | Neurology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.2]
- Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota.
- Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with Bilophila wadsworthia confers CI in mice fed a standard diet.
- B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression.
- The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI. - [1.1]
- Barnesiella was positively associated with the first principal component, DSST, and category fluency;
- Lachnospiraceae FCS020 group was positively associated with DSST.
- Sutterella was negatively associated with MoCA - [1.3]
- Long-term antibiotic use in midlife is associated with small decreases in cognition assessed seven years later.