Disease ⇒ Cognitive impairment {40000159}

References Notes

Shared Reference Notes

• [1.2] 
  - Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota.
  - Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with Bilophila wadsworthia confers CI in mice fed a standard diet.
  - B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression.
  - The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI.
• [1.1] 
  - Barnesiella was positively associated with the first principal component, DSST, and category fluency;
  - Lachnospiraceae FCS020 group was positively associated with DSST.
  - Sutterella was negatively associated with MoCA
• [1.3] 
  - Long-term antibiotic use in midlife is associated with small decreases in cognition assessed seven years later.