Disease ⇒ Cognitive impairment {40000159}

Shared Reference Notes

• [1.1] [#Keto diet] 
  - Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota. - Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with #Bilophila wadsworthia confers CI in mice fed a standard diet. - B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression. - The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI.
• [1.2] 
  - #Barnesiella was positively associated with the first principal component, DSST, and category fluency; - #Lachnospiraceae FCS020 group was positively associated with DSST. - #Sutterella was negatively associated with MoCA
• [1.3] [#Antibiotic Therapy] 
  - Long-term antibiotic use in midlife is associated with small decreases in cognition assessed seven years later.
• [1.4] [#Alzheimer’s disease, #Mild Cognitive Impairment] [#Mediterranean Ketogen Diet] 
  - Participants with MCI on the MMKD had lower levels of #GABA-producing microbes #Alistipes sp. CAG:514 and #GABA, and higher levels of #GABA-regulating microbes #Akkermansia muciniphila.
• [#American Heart Association Diet] - the low-fat AHAD modulates key #Neurotransmitters, such as promoting #GABA production, in individuals with cognitive impairment. This dysregulation may be related to increases in #GABA-producing microbes, such as #Alistipes sp. CAG:514.
• [1.5] 
  - #Butyrate administration to animals has shown protective effects against vascular #Dementia, cognitive impairment, and against metabolic risk factors for cognitive decline and #Dementia
• [#Mild Cognitive Impairment] [#Bacteriophage] - higher abundance of #Lactobacillus phages (family #Siphoviridae of the order #Caudovirales positively associated with better cognitive function; and transplantation of these phages from humans to mice and Drosophila showed increased memory scores and upregulation of memory-involved brain genes.
• [1.6] [#Mild Cognitive Impairment] [#Olive] 
  - participants who consumed a #Mediterranean diet supplemented with either EVOO or #Nuts had improved cognitive function compared with those that consumed a low-fat diet.
• [#Olive] - increase in complexin 1, a presynaptic neuronal protein, and a notable decrease in tau oligomers in mice fed EVOO, resulting in enhanced short-term plasticity and memory.
• [1.7] [#Alzheimer’s disease] [#Amyloid-beta] 
  - Aβ was associated with increased plasma phosphorylated tau and cognitive impairment only in those who tested positive for astrocyte reactivity (Ast+).
• [1.8] [#Short Chain Fatty Acid] 
  - The pathway most associated with healthy individuals (l-#Glutamate degradation V) produces the SCFA #Acetate, which not only has been observed to inhibit Aβ aggregation in vitro and protect against cognitive impairment in mice but also has been associated with an elevated Aβ SUVR in a human cohort
• [#Faecalibacterium prausnitzii] - specific strains of F. prausnitzii from healthy participants reduced cognitive impairment in a murine model of brain amyloidosis.
• [1.9] 
  - #Constipation may not be a necessary condition for steeper cognitive decline. Rather, a condition without #Constipation may support a relatively slow decline in cognitive impairment.
• [#Glutamate, #Glutamine] - Disruption within the glutamatergic pathway can lead to cognitive deficits, #Schizophrenia and frontotemporal #Dementia
• [1.11] [#Lactobacillus plantarum] 
  - Intake of Lactiplantibacillus plantarum LPHEAL9 significantly improved cognitive functions compared to the placebo, potentially by ameliorating aspects of mood and #Sleep.
• [1.12] [#Alzheimer’s disease] 
  - administrating feces of AD transgenic mice to wild-type mice resulted in AD-associated gut microbiota dysbiosis, #Tau phosphorylation, and cognitive impairment in the wild-type mice. - The oral and gut microbiota of AD patient partners resembled that of AD patients but differed from healthy controls, indicating the transmission of microbiota. - #Butyric acid-mediated acetylation of GSK3β at lysine 15 regulated its phosphorylation at serine 9, consequently impacting #Tau phosphorylation.
• [1.13] 
  - #Arabinoxylan and #Arabinose, can enhance general cognition and attenuate the accumulation process of #Dementia-related glial fibrillary acidic protein in mice
• [1.14] [#Depression, #Hearing loss] 
  - significant negative correlation between urinary #Glyphosate levels and cognitive function. - severe depressive symptoms were significantly higher than having no symptoms in individuals with higher #Glyphosate levels. - individuals reporting serious hearing difficulty in individuals with higher #Glyphosate levels.
• [1.15] [#Alzheimer’s disease] 
  - co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, #Tau phosphorylation, and cognitive impairment. - Gavage with #Lactobacillus and #Bifidobacterium restored these changes.
• [1.16] [#Malondialdehyde] [#Citrus and pomegranate complex] 
  - After four weeks of supplementation with CPC, handgrip strength significantly improved, as compared to placebo, which deteriorated. - self-evaluated psychological function showed a trend for improvement after CPC supplementation > significantly higher score for the CPC group in the thinking, memory, learning, and concentration facet, as compared to the placebo group. - a significant decrease in MDA was observed after CPC supplementation.
• [1.17] [#Dairy] 
  - cheese intake was found to be a factor that was inversely associated with lower cognitive function.
• [#Whole grains] - grain products increased their risk of cognitive decline by 40%, whereas an increased intake of #Dairy products reduced the risk of cognitive decline by 20%
• [1.18] [#Lipopolysaccharide] 
  - TG-treated SAMP8 mice exhibited significant improvement in the parameters of escape latency, distance moved, and annulus crossing index. - #Trigonelline treatment significantly reduces TNFα and IL6 protein levels in SAMP8 mice hippocampus. - it also suppressed LPS-induced TNFα mRNA expression in SH-SY5Y cells. - TG may exert its biological effects through negatively modulating Traf6-mediated NF-κB activation.
• [1.19] 
  - decrease in #Prevotella histicola and #Prevotella oulorum > in the oral cavity of patients with #Rheumatoid Arthritis, and cognitive decline
• [#Nuts] - higher nut intake was associated with better cognitive function.
• [1.21] [#Alzheimer’s disease] 
  - repeated short exposures to #Menthol odor enhanced the immune response against ovalbumin immunization. - #Menthol inhalation also improved the cognitive capacity of immunocompetent mice but not in immunodeficient NSG mice, which exhibited very poor fear-conditioning. - Exposure to #Menthol for 6 months (1 week per month) prevented the cognitive impairment observed in the APP/PS1 mouse model of Alzheimer. - this improvement was also observed by the depletion or inhibition of T regulatory cells.
• [1.22] [#Alzheimer’s disease] [#Porphyromonas gingivalis] 
  - patients with AD exhibited higher blood levels of anti-P. gingivalis IgG > is associated with specific cognitive impairment
• [1.23] [#Constipation] 
  - Compared to those with BM once daily, participants with BM frequency every 3+ days had significantly worse objective cognitive function, equivalent to 3.0 years of chronological cognitive #Aging.
• [1.24] 
  - genus #Eisenbergiella increases with severity of cognitive impairment and that genus #Desulfovibrio was negatively correlated with MMSE scores.
• [1.25] [#Prevotella intermedia] 
  - serum antibody levels specific for P. intermedia have been reported to be associated with cognitive deficits
• [1.26] [#Adlercreutzia equolifaciens] 
  - A. equolofaciens subspecies celatus was also the most important features in RF models of the right anterior cingulate, which has been linked to social cognition and reward-based decision making - estrogen has previously been shown to have activity in this brain region
• - #Alistipes obesi, #Blautia wexlerae, and #Ruminococcus gnavus were enriched or depleted in #Children with higher cognitive function scores.
• [#Anaerostipes hadrus, #Blautia wexlerae] - B. wexlerae and A. hadrus were among the top 15% important predictors on both left and right thalamus and the expressive language subscale.
• [#Bacteroides finegoldii, #Blautia wexlerae, #Roseburia faecis] - B. wexlerae, #Dorea longicatena, R. faecis, and A. finegoldii, are #Clostridiales > positively associated with cognitive function in children.
• [#Clostridium cluster I, #Streptococcus salivarius] - Previous results also link to relationships between the caudate and the cerebellum, and the visual reception score. - S. salivarius was consistently found among the top 20% predictors for this subscale, along with both sides of the thalamus and cerebellum white matter, along with cerebellar vermal lobules I to X.
• [#Fusicatenibacter saccharivorans] - #Butyrate-producing F. saccharivorans is among the 15% most important predictors for both the gross motor subscale and three bilateral components of the COC (left and right pars orbitalis, pars opercularis and pars triangularis).
• [#Polyphenols, #Urolithins] - #Gordonibacter pamelaeae, also has a unique metabolism that may affect the brain, as it can metabolize the polyphenol #Ellagic acid (found in pomegranates and some berries) into urolithin, which has been shown in some studies to have a neuroprotective effect
• [#Ruminococcus gnavus] - R. gnavus, which we found was negatively associated with cognitive function
• [1.27] 
  - #Megasphaera is associated with cognitive impairment and inflammation in patients with #Hepatic encephalopathy.
• [1.28] [#Bacteroides-Prevotella group] 
  - Families including #Bacteroidaceae, #Rikenellaceae, along with genera including #Paraprevotella, Ruminococcustques group, #Bacteroides, #Dialister, #Paraprevotella, and RuminococcaceaeUCG003 had a protective effect on cognition.
• - genus #Roseburia, #Blautia, Catenibacteriu, and #Oxalobacter had a negative impact on cognitive performance, with #Roseburia strongly associated with outcome.
• [1.29] [#Chronic fatigue syndrome] 
  - #Vitamin E in improving mental health, particularly cognitive function. - certain gut microbes, like #Bacteroides and #Clostridium, are considered to possess the potential ability to metabolize #Vitamin E in the intestinal tract. - the cognitive issues observed in ME/CFS patients may be associated to specific changes in the gut microbiome and a significant reduction in #Vitamin E levels.
• [#Amyloid-beta] - 12-week #Vitamin A-deficient diet resulted in decreased serum retinol levels, impaired cognition, and increased Aβ pathologies in the hippocampus of APP/PS1 mice.
• [#Amyloid-beta] - a #Vitamin A-enriched diet led to higher serum retinol levels, preserved cognition, and reduced Aβ pathologies in the hippocampus of APP/PS1 mice.
• [1.31] [#Mild Cognitive Impairment] 
  - #Roseburia inulinivorans showed negative correlations with the scores of the Functional Activities Questionnaire
• - #Bifidobacterium adolescentis is associated with better performance in multiple cognitive scores and several serum indicators.
• [1.32] 
  - In stool, #Bifidobacterium abundance correlated with #4-hydroxyphenyllactate, which is a metabolite of #Tyrosine—a catecholamine precursor associated with cognitive function.
• [1.33] 
  - #Inosine was shown to improve cognitive function and to decrease neuroinflammation in ageing rats
• [1.34] 
  - In #Depression > Poor current cognitive function associated with lower relative abundance of #Bifidobacterium
• - higher abundance of #Bacteroidota and lower abundance of #Bifidobacterium predict lower cognitive functioning.
• - Supplementing #Bifidobacterium improves cognitive function in animal models and people with varying levels of cognitive impairment
• - cognitive decline was associated with lower baseline #Glutamate degradation and higher #Histamine synthesis potential.
• - cognitive decline was associated with decreased relative abundance of #Intestinibacter – a hallmark of gut dysbiosis suggesting inflammation-driven cognitive decline and increased biological #Aging
• - Future cognitive decline associated with lower cognitive function, lower relative abundance of #Intestinibacter, lower #Glutamate degradation, and higher baseline #Histamine synthesis.

References Notes