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Microbiome & Chronic Diseases

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Inulin [Helenin, Alatin, Meniantin] {60000102}

Record Keys


Biotic:
Inulin
Parent:[  ]
Queue:
Helenin, Alatin, Meniantin

Details


Initialisation date:
2020-10-17
Specification:

- dietary fibers
- fructans

Source:

- Elecampane (Inula helenium)
- Chicory, roots or rhizomes, wheat, onion, bananas, garlic, asparagus, Jerusalem artichoke

Links


Meta Information


Structural Type:
Carbohydrate
Functional Type:
Energy Source
Function:
Anti-cancer

Notes:


[  ]

Shared Notes


  • [1.2
    - Inulin improve gut dysbiosis, lower testosterone, and increase estradiol levels while improving ovarian morphology and weight gain in mice fed a high-fat diet
  • [1.3
    - In multiple murine tumour models, inulin—a widely consumed dietary fibre—formulated as a ‘colon-retentive’ orally administered gel can effectively modulate the gut microbiome in situ, induce systemic memory-T-cell responses and amplify the antitumour activity of the checkpoint inhibitor anti-programmed cell death protein-1 (α-PD-1).
    - Orally delivered inulin-gel treatments increased the relative abundances of key commensal microorganisms and their short-chain-fatty-acid metabolites, and led to enhanced recall responses for interferon-γ+CD8+ T cells as well as to the establishment of stem-like T-cell factor-1+PD-1+CD8+ T cells within the tumour microenvironment.
  • [1.1
    - vegetables rich in inulin increased Bifidobacterium levels, promoted satiety, and reduced body weight

Common References