Ruminococcaceae ⇒ Ruminococcus {10000246}

Shared Reference Notes

• [1.1] [#Amyotrophic lateral sclerosis] 
  - Greater abundance of Ruminococcus, at genus level > related to higher risk of ALS. - #kynurenine > risk factor of ALS.
• [1.2] [#Colitis, #Crohn’s disease] [#Candida tropicalis] 
  - C. tropicalis > induces dysbiosis that involves changes in the presence of mucin-degrading bacteria #Akkermansia muciniphila and Ruminococcus gnavus > leading to altered tight junction protein expression with increased intestinal permeability > followed by induction of robust Th1/Th17 responses > lead to an accelerated proinflammatory phenotype in experimental colitic mice.
• [1.3] [#Lactobacillus paracasei] 
  - The #Fibrosis-triggering microbial populations in the cecum as mucolytic bacteria : the species #Mucispirillum schaedleri, the genus Ruminococcus, and the genus #Anaeroplasma, and in the ileum, such as the genera #Streptococcus and Lactobacillus.
• [1.4] 
  - Barley contains abundant soluble #Beta-glucan fibers - #Bifidobacterium, #Butyricicoccus, #Collinsella, Ruminococcus 2, and #Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley. - The relationship between #Barley consumption and #Bifidobacterium remained after adjusting for disease and dietary habits, and that of #Butyricicoccus remained after adjusting for disease. - Network and cluster analyses revealed that #Barley consumption was directly correlated with #Bifidobacterium and #Butyricicoccus.
• [1.5] [#Parkinson’s Disease] 
  PD patient group, the abundance of proinflammatory microbes, such as #Clostridiales bacterium NK3B98 and Ruminococcus sp AM07-15, significantly correlated with decreased fecal levels and increased plasma levels of SCFAs, especially #Propionic acid.
• [1.6] 
  - patients with psoriasis report a relative reduction in intestinal abundance of #Akkermansia, Ruminococcus, or #Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
• [1.7] [#Gallstone Disease] 
  - Ruminococcus spp., another important butyrate producing bacteria, significantly decreased in patients with CGSs from the present study. Some authors recently proposed that these bacteria to be considered markers for distinguishing patients with GSD from healthy controls.
• [1.8] [#Asthma] [#Children] 
  - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium, #Faecalibacterium, Ruminococcus, and #Roseburia) are associated with childhood respiratory diseases.
• [1.9] [#Irritable bowel syndrome] 
  - Ruminococcus to be increased in IBS patients, suggesting even a potential role as a biomarker of this disorder
• [#Vegetarian diet] - Dominant species in vegetarians are Ruminococcus, #Roseburia, and #Eubacterium.
• [1.11] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] 
  The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) #Roseburia, #Eubacterium, #Subdoligranumum, Ruminococcus - an increase in pro-inflammatory pathogens #Proteus, #Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, #Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus.
• [1.12] [#Crohn’s disease] [#Clostridium cluster IV] 
  - #Roseburia, #Gemmiger, #Coprococcus, Ruminococcus 2, #Butyricicoccus, #Dorea, #Fusicatenibacter, #Anaerostipes, Clostridium IV were enriched in the healthy controls. - #Blautia, Clostridium IV, #Coprococcus, #Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between #Dorea, #Butyricicoccus, #Roseburia and gland reduce, #Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, #Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, Ruminococcus 2 and clinical symptoms.
• [1.13] 
  - Butyrylated high-amylose maize resistant starch decreased red meat-derived pro-mutagenic adduct O6-methyl-2-deoxyguanosine and related CRC risk. - Certain #Butyrate-producing bacteria such as #Clostridium, Ruminococcus, #Faecalibacterium spp., #Eubacterium spp., and #Roseburia, were found to decrease in relative frequency in CRC patients. - #Butyrate inhibited the growth of CRC cells and induced their apoptosis in vitro at pharmacologically high concentrations.
• [1.14] [#Diabetes Type 2] 
  - A significant reduction of genera #Alistipes, #Anaerostipes, Ruminococcus was detected in the T2D group.
• [1.15] [#Bacteroides barnesiae, #Dorea formicigenerans] 
  - #Rice bran > increase genera Ruminoccocus, Dorea, and Bacteroides
• [1.16] [#Bipolar disorder, #Major depressive disorder] 
  - MDD and BD had more commonalities, including higher #Enterococcus, #Flavonifractor, and #Streptococcus, and lower #Faecalibacterium and Ruminococcus.
• [1.17] [#High-protein diet] 
  - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, #Prevotella, Ruminococcus, #Roseburia, and #Faecalibacterium.
• [1.18] [#Mild Cognitive Impairment] 
  - the ratio of Ruminococcus sp. CAG:330 to #Bacteroides fragilis CAG: 47 is consistently elevated in MCI
• [1.19] [#Soybean] 
  - diet containing soy protein resulted in increased abundance of Enterococus and decreased abundance of #Lactobacilli and Ruminococus in rats
• [#Inflamatory bowel disease] - transient blooms of pro-inflammatory Ruminococcus have been associated with active flare-ups in IBD.
• - Enriched Ruminococcus is associated with #Irritable bowel syndrome (IBS).
• [1.21] [#Diabetes Type 2] [#Resistant starch] 
  - Ruminococcus was shown to possess an exceptional ability to colonize and degrade #Starch particles, which in turn alleviates insulin resistance.
• [#Fusobacterium varium] - #Lachnospiraceae bacterium and members of Ruminococcus and #Fusobacterium species, including #Fusobacterium ulcerans and #Fusobacterium varium, were found to be enriched in patients with #Obesity
• [1.22] [#Celiac Disease] 
  - #Bacillus subtilis LZU-GM was isolated from Pakistani traditional fermented sourdough and could degrade 73.7% of #Gluten in 24 h in vitro. - The #Gluten degradation was 3-fold higher in the small intestine of the strain LZU-GM treated mice group. - #Gluten-treated mice established positive antigliadin antibodies (AGA) in serum (IgA, IgG, and anti-TG2 antibodies) as compared to the strain LZU-GM treatment group. - the number of IFN-γ, TNF-α, #IL-10, and COX-2 cells decrease in the lamina propria of the strain LZU-GM treatment group. - Microbial community bar plot analysis showed that #Lactobacillus, #Dubosiella, and #Enterococcus genera were restored and stabilized in the LZU-GM treatment group while #Blautia and Ruminococcus were found lower.
• [1.23] [#Crohn’s disease] [#Dorea longicatena, #Ruminococcus lactaris] 
  - ileocolonic resection (ICR) in CD patients > amples collected at time of surgery were enriched in #Proteobacteria and harbored high levels of unusual, bacteria such as #Streptococcus mitis, #Undibacterium oligocarboniphilum, #Sphingomonas melonis and #Gemella haemolysans - 6 months after surgery samples had elevated proportions of anaerobic bacteria belonging to #Lachnospiraceae (#Clostridium nexile, #Blautia wexlereae, #Dorea longicatena). - Remission was characterized by increased levels of bacteria belonging to #Bacteroides, #Dorea, Ruminococcus and #Dialister genera, whereas recurrence was associated with increased levels of #Gemmiger formicilis, #Enterococcus durans and Ruminococcus lactaris.
• [1.24] [#Irritable bowel syndrome] 
  - IBS was typified by enhanced quantities of #Firmicutes and specifically in Ruminococcus, #Clostridium, and #Dorea, along with a distinct decrease of beneficial microbes, such as #Bifidobacterium and #Faecalibacterium spp
• [1.25] 
  - A similar correlation with high absolute tissue eosinophil counts and percentages of tissue eosinophils is also seen in the abundance of the genera #Parabacteroides, #Bifidobacterium, #Bacteroides, #Microbacterium, #Faecalibacterium, #Lactococcus, #Desulfovibrio, and Ruminococcus.
• [#Children] - the abundances of #Bifidobacterium and Ruminococcus increased gradually over time from age 6 months to age 8 years
• [#Eosinophilic chronic rhinosinusitis] - nasal dysbiosis in eCRSwNP was defined by increased relative abundances of #Sphingomonas, #Moraxellaceae, #Bacteroides, #Bifidobacterium, Ruminococcus, and #Faecalibacterium, as well as by decreased abundances of #Ralstonia, #Propionibacterium, and Propionibacter.
• [1.26] 
  - protective role against #Female infertility, > Ruminococcus, #Desulfovibrio. #Bifidobacteriales, #Bifidobacterium, #Actinobacteria, #Ruminococcaceae NK4A214, #Bifidobacteriaceae, #Actinobacteria, #Holdemania.
• [1.27] [#Systemic lupus erythematosus] 
  - SLE > The abundance of #Acholeplasma, #Capnocytophaga and #Leptotrichia were negatively correlated with SLEDAI score, and the abundance of #Bacteroides, Ruminococcus and #Akkermansia had an inverse correlation with the serum levels of complement C3
• [1.28] [#Crohn’s disease] 
  - CD patients had higher abundances of a Ruminococcus taxon and strongly depleted in a #Blautia ASV, and previous csDMARD therapy was associated with increased #Akkermansia.
• [1.29] 
  - Most gram-positive bacteria, like Ruminococcus and #Clostridium, and some gram-negative bacteria can metabolize #Bile Acids .
• [#Short Chain Fatty Acid] - increased abundance of gut #Ruminococcus and ##Alistipes in castration-resistant #Prostate cancer (CRPC) patients along with ##Bacteroidales, ##Rikenellaceae, ##Faecalibacterium,the so called SCFAs-producing microbiotas.
• [#Prostate cancer] [#Short Chain Fatty Acid] - FMT with CRPC patients’ fecal suspension > increase SCFAs-producing gut microbiotas such as Ruminococcus, #Alistipes, Phascolarctobaterium in TRAMP, and correspondingly raised their gut SCFAs (#Acetate and ##Butyrate) levels.
• [#Prostate cancer] - gut Ruminococcus was significantly more abundant in CRPC individuals.
• [1.31] [#Clostridiales XIV, #Clostridium cluster IV] 
  - #Walnut consumption at 42 g/day, increased #Butyrate-producing #Clostridium clusters XIV and IV including, #Faecalibacterium, #Roseburia, while lowering the relative abundance of Ruminococcus, #Dorea, Oscilllo, #Bifidobacteria.
• [1.32] 
  - In patients with #Psoriatic Arthritis, there was a decrease in the abundance of certain bacteria such as #Akkermansia, Ruminococcus, #Pseudobotyrivibrio, #Paraacteroides, #Alistipes, and #Coprococcus
• [1.33] [#Prostate cancer] 
  - Ruminococcus can convert pregnenolone and hydroxypregnenolone to dehydroepiandrosterone (DHEA) and testosterone, which are downstream metabolites. - Abiraterone #Acetate, a specific inhibitor of CYP17A1, prevents the bacterial conversion of pregnenolone to DHEA and testosterone. - Ruminococcus possesses genes with significant sequence similarity with human CYP17
• [1.34] [#Metabolic syndrome] 
  - #Ruminococcaceae UCG-014 was disadvantageous for weight loss, while #Ruminococcaceae NK4A214 and Ruminococcus 1 were advantageous for weight loss and change in waist circumference. - baseline abundance of this taxon was positively associated with DNAme in three metabolically relevant genes.
• [1.35] 
  - patients with #Celiac Disease showed the abundance of #Streptococcus, #Lactobacillus, #Veillonella, and #Allisonella species, while the abundance of Ruminococcus, #Faecalibacterium, #Blautia, #Gemmiger, and #Anaerostipes was decreased.
• [1.36] [#Non-Hodgkin lymphoma] [#CAR T-cell therapy] 
  - In Lymphoma > #Bacteroides, Ruminococcus, #Eubacterium and #Akkermansia were most important in determining CAR-T responsiveness, with #Akkermansia also being associated with pre-infusion peripheral T cell levels in these patients.
• [1.37] [#Clostridium difficile associated disease, #Clostridium difficile infection] 
  - patients who are likely to develop R-CDI have higher levels of #Calprotectin, together with a higher abundance of #Fusobacterium and lower abundance of #Senegalimassilia, #Prevotella and Ruminococcus.
• [#Clostridium difficile associated disease] - #Fusobacterium increased in abundance, while #Collinsella, #Senegalimassilia, #Prevotella and Ruminococcus decreased in patients with recurrent versus non-recurrent disease.
• [1.38] [#Inflamatory bowel disease] 
  - Ruminococcus, is able to influence colon function via vitamin synthesis pathway. - in the IBD patients, metabolic pathway vitamin digestion and absorption and Ruminococcus spp. were significantly altered
• - Ruminococcus has been found to be related to #Vitamin D biosynthesis
• [1.39] [#Diabetes Type 2, #Gallstone Disease, #Kidney stone, #Urinary stone disease] 
  - #Eggerthella, #Flavonifractor, and Ruminococcus spp., all of which were enriched in SF, have recently been suggested as general disease-associated signatures (shared across type 2 diabetes, diarrhoea and #Constipation, mental disorders, and gallstones)
• [#Metabolic associated fatty liver disease] - increased abundance of Ruminococcus following #Beta-glucan treatment > improvement in MASLD progression.
• [#Western-style diet] - significant reduction of Ruminococcus in the mice that had been fed WSD in comparison to the control group. - This shift was partially reversed after #Beta-glucan treatment
• [1.41] [#Bacteroides-Prevotella group, #Ruminococcus gauvreauii] 
  - marked reduction in #Butyrate-producing bacterial genera, such as #Coprococcus, and #Subdoligranulum, in both the ileum and colon; #Faecalibacterium in colon; and [Ruminococcus] gauvreauii group in fecal samples from People living with HIV (PLWH)
• [1.42] 
  - levels of #Prevotella, #Dehalobacterium, Ruminococcus, and #Lactobacillus were found to be remarkably lower in rat model of #Hyperuricemia.
• [1.43] [#Chronic fatigue syndrome] 
  - a significant decline in serum #Butyrate levels were found in ME/CFS patients. - decrease in #Butyrate-producing bacteria among ME/CFS patients involving genus/species like Ruminococcus, #Faecalibacterium prausnitzii, and #Eubacterium rectale. - the abundance of these species were negatively correlated with the severity of fatigue symptoms in ME/CFS patients.
• [1.44] [#Tryptophan] 
  - Trp is converted to #Indole via the enzyme Trp identified in gut bacteria such as #Escherichia coli (E. coli), #Clostridium spp., and #Bacteroides spp. - Trp decarboxylase converts Trp to #Tryptamine > is expressed in #Clostridium, Ruminococcus, #Blautia, and #Lactobacillus bacteria
• [1.45] [#Schizophrenia] 
  - #Shigella and #Collinsella were more abundant in SCZ patients, and #Faecalibacterium, #Coprococcus, #Prevotella, #Haemophilus, Ruminococcaceae_Ruminococcus, #Bacteroides, and #Oscillospira are significantly abundant in HC
• [1.46] [#Anthocyanins] 
  - Subtle differences were observed in the faecal microbiota of subjects that were fed the different apples, with significant reductions in relative abundances of #Streptococcus, Ruminococcus, #Blautia, and #Roseburia, and increased relative abundances of #Sutterella, #Butyricicoccus, and #Lactobacillus in subjects after consuming the red #Apple. - anthocyanin-rich apples may influence immune function compared to control apples
• [1.47] [#Metabolic associated fatty liver disease] 
  - Patients with lean MAFLD exhibited enrichment in #Erysipelotrichaceae UCG-003, Ruminococcus, #Clostridium sensu stricto 1, #Romboutsia, and #Ruminococcaceae UCG-008.
• [#Metabolic Dysfunction-associated Steatohepatitis] - patients with lean NASH had a threefold reduction in the abundance of #Faecalibacterium and Ruminococcus
• [1.48] [#Blautia] 
  - Specific human gut microbes, including Ruminococcus_E, #Agathobacter, #Fusicatenibacter, #Anaerobutyricum, Blautia_A and #Neisseria, were identified as potential consensus microbial biomarkers for #Obesity in the population.

References Notes