Disease ⇒ Heart failure {40000230}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Heart failure

Details


Initialisation date:[  ]
Other Terms:
HF

Meta Information


MedDra ID:
10019285
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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Shared Reference Notes


  • [1.1] [#CVD, #Hearth attack
  • [1.2] [#Eubacterium hallii, #Lachnospiraceae, #Ruminococcaceae
    - patients with HF have a decrease in #Butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families. - reduction of the #Butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
  • [1.3
    - #TMAO levels are also associated with heart failure and #Coronary artery disease. - #TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease.
  • [1.4
  • [1.5] [#Atrial fibrillation
    - possible negative association of prevalent AF with #Bifidobacterium, and a positive relation for incident AF. - In heart failure patients, the genus #Bifidobacterium is depleted. - #Bifidobacterium has been positively correlated with ejection fraction and negatively with the cardiac stress marker N-terminal pro B-type natriuretic peptide.
  • [#Atrial fibrillation] - #Enorma, #Bifidobacterium, and #Eisenbergiella were among the top associations of prevalent and incident AF. - At the genera level, the top association of prevalent AF was observed with #Enorma. - #Enorma belongs to the family of Coriobacteriaceae, which were among the core families related to heart failure
  • [1.6] [#L-urobilin
    - #Urobilin concentrations also have an impact on human health, being positively correlated with insulin resistance and heart failure

References Notes


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