Disease ⇒ Heart failure {40000230} Record Keys Type:Disease Parent:[ ] Definition:Heart failure Details Initialisation date:[ ] Other Terms:HF Meta Information MedDra ID:10019285 MedDra Level:llt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#CVD, #Hearth attack] [1.2] [#Eubacterium hallii, #Lachnospiraceae, #Ruminococcaceae] - patients with HF have a decrease in #Butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families. - reduction of the #Butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality [1.3] - #TMAO levels are also associated with heart failure and #Coronary artery disease. - #TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease. [1.4] [1.5] [#Atrial fibrillation] - possible negative association of prevalent AF with #Bifidobacterium, and a positive relation for incident AF. - In heart failure patients, the genus #Bifidobacterium is depleted. - #Bifidobacterium has been positively correlated with ejection fraction and negatively with the cardiac stress marker N-terminal pro B-type natriuretic peptide. [#Atrial fibrillation] - #Enorma, #Bifidobacterium, and #Eisenbergiella were among the top associations of prevalent and incident AF. - At the genera level, the top association of prevalent AF was observed with #Enorma. - #Enorma belongs to the family of Coriobacteriaceae, which were among the core families related to heart failure [1.6] [#L-urobilin] - #Urobilin concentrations also have an impact on human health, being positively correlated with insulin resistance and heart failureReferences Notes[ ]
