Disease ⇒ Chronic periodontitis {40000290}

Shared Reference Notes

• [1.1] [#Periodontal disease] 
  - #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (#Leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
• [1.2] [#Lactobacillus lactis] [#Nisin probiotic] 
  - #Nisin and a #Nisin-producing Lactococcus lactis probiotic significantly decreased the levels of several periodontal pathogens, alveolar bone loss, and the oral and systemic inflammatory host response. - Surprisingly, #Nisin and/or the #Nisin-producing L. lactis probiotic enhanced the population of fibroblasts and osteoblasts despite the polymicrobial infection.
• [1.3] [#Diabetes Type 2] 
  - Elevated IL-6 and CRP levels associated with Periodontitis, as significant risk factors for insulin resistance and diabetes mellitus
• [1.4] [#Periodontal abscess] 
  - periodontopathogens can be disseminated through the blood flow to other body parts where they may enhance inflammatory processes that can lead to the development or exacerbation of #Atherosclerosis.
• [1.5] [#Periodontal disease] [#Fusobacterium nucleatum] 
  - Chronic oral infection establishes ectopic oral F. nucleatum colonization in the intestine and significantly induces systemic humoral IgG and IgM antibody responses

References Notes