High-protein diet {51111259} Record Keys Definition:High-protein diet Queue:[ ] Details Initialisation date:2022-01-03 Specification: [ ] Meta Information Type:Diet Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - High-protein group > decreased abundance of #Veillonellaceae, #Akkermansia, uncultured #Eggerthellaceae, and #Ruminococcaceae UCG-010 [#Exercise training] - protein-supplemented group without exercise > increases in trimethylamine-N-oxide (#TMAO) and #Phenylacetylglycine (PAG). - In contrast, the addition of exercise decreases #TMAO [1.2] - the microbiota of high protein fed mice produces significantly higher quantities of extracellular vesicles, compared to those of mice fed high-carbohydrate or high-fat diets. These extracellular vesicles activate Toll-like receptor 4 to increase the epithelial expression of IgA-inducing cytokine, APRIL, B cell chemokine, CCL28, and the IgA transporter, PIGR. - #Succinate, produced in high concentrations by microbiota of high protein fed animals, increases generation of reactive oxygen species by bacteria, which in turn promotes extracellular vesicles production. [1.3] [#Branched short-chain fatty acids, #Isobutyric acid, #Isovaleric acid] - Both isobutyric and isovaleric acids are BSCFAs, which are produced by fermentation of #Branched-chain amino acids by intestinal flora. Milk and dairy products are unique dietary sources of BCFAs. - Higher levels of BCFAs are produced when eating a high-protein/low-carbohydrate diet [1.4] - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, #Prevotella, #Ruminococcus, #Roseburia, and #Faecalibacterium. [#Phenol] - Excessive fermentation of undigested protein residues in the colon increases the amount of #Ammonia, biogenic amines, #Indole compounds, and phenols. [1.5] - #Intestinibacter of #Firmicutes phylum was positively correlated with protein-derived energy.References Notes[ ]
