Lactoferrin {90000136}

Record Keys

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Meta Information

Structural Type:[  ]
Functional Type:[  ]
Immun regulator, Anti-inflammatory, Anti-bacterial, Anti-cancer, Antioxidant, Enhancing Gut integrity


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Shared Reference Notes

  • [1.1
    - LF promotes the growth of low iron requiring bacteria thought to be beneficial to humans such as Lactobacillus and Bifidobacterium. - LF has direct fungicidal interaction against fungal cell surface that is not dependent on iron. - Lactoferrin exhibit immunomodulatory properties.
  • [1.2
    - LF > iron donor to support the growth of some bacteria with lower iron demands > #Lactobacillus sp. or #Bifidobacterium sp.
  • - LF > binding with free iron >The lack of iron in Gut > suppresses the growth of #Escherichia coli (E. coli.), an iron-dependent bacteria
  • [#Inflamatory bowel disease] - Lactoferrin > potent anti-inflammatory and immunomodulatory substrate > prevention and treatment of IBD through regulating intestine mucosal immune response.
  • - Lactoferrin (LF), an iron-binding glycoprotein belonging to transferrin family, is a dietary bioactive component abundantly found in mammalian milk. - LF > perform diverse biological functions including antibacterial activity, anti-inflammatory activity, intestinal barrier protection, and immune cell modulation, and is involved in maintaining intestine mucosal immune homeostasis. - LF treatment > reduced the secretion and gene expression of tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8), interleukin-6 (IL-6), and nuclear factor-κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3) signaling pathway activation.
  • [1.3] [#Human milk oligosaccharides] [#Human breast milk
    - Breast milk contains important developmental and immune-promoting factors such as oligosaccharides, immunoglobulins (IgA), and lactoferrin which protect the newborn passively and actively against excessive intestinal inflammation
  • [1.4
    - lactoferrin > suppresses biofilm formation by stimulating twitching, a specialized form of surface motility
  • [1.5
    - supplementation of #Lysozyme and lactoferrin to #Children aged 12–23 months in rural Malawi resulted in improved gut health as determined by their ingested #lactulose excreted into the urine, along with decreased rates of hospitalization

References Notes

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