Lactoferrin {90000136}

Shared Reference Notes

• [1.1] 
  - LF promotes the growth of low iron requiring bacteria thought to be beneficial to humans such as Lactobacillus and Bifidobacterium. - LF has direct fungicidal interaction against fungal cell surface that is not dependent on iron. - Lactoferrin exhibit immunomodulatory properties.
• [1.2] 
  - LF > iron donor to support the growth of some bacteria with lower iron demands > #Lactobacillus sp. or #Bifidobacterium sp.
• - LF > binding with free iron >The lack of iron in Gut > suppresses the growth of #Escherichia coli (E. coli.), an iron-dependent bacteria
• [#Inflamatory bowel disease] - Lactoferrin > potent anti-inflammatory and immunomodulatory substrate > prevention and treatment of IBD through regulating intestine mucosal immune response.
• - Lactoferrin (LF), an iron-binding glycoprotein belonging to transferrin family, is a dietary bioactive component abundantly found in mammalian milk. - LF > perform diverse biological functions including antibacterial activity, anti-inflammatory activity, intestinal barrier protection, and immune cell modulation, and is involved in maintaining intestine mucosal immune homeostasis. - LF treatment > reduced the secretion and gene expression of tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8), interleukin-6 (IL-6), and nuclear factor-κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3) signaling pathway activation.
• [1.3] [#Human milk oligosaccharides] [#Human Milk] 
  - Breast milk contains important developmental and immune-promoting factors such as oligosaccharides, immunoglobulins (IgA), and lactoferrin which protect the newborn passively and actively against excessive intestinal inflammation

References Notes