Porphyromonadaceae ⇒ Odoribacter {10000219}

Shared Reference Notes

• [1.1] [#Inflamatory bowel disease] 
  - In IBD > reduced levels of #Christensenellaceae, Odoribacter, #Mogibacteriaceae and #Gemmiger and increased abundance of #Peptostreptococcaceae.
• [1.2] [#Hypertension] 
  - Abundance of #Blautia and Odoribacter showed a negative correlation with high SBP
• [1.3] [#Alzheimer’s disease] 
  - AD Mouse > an increase in Odoribacter and #Helicobacter genera and decreases in #Prevotella species.
• [1.4] [#Alzheimer’s disease] 
  - Increased proportions of Odoribacter and #Barnesiella and decreased proportions of #Eubacterium , #Roseburia , #Lachnoclostridium and #Collinsella were seen in elders with other #Dementia types than AD.
• [#Alzheimer’s disease] - Increased proportions of #Bacteroides, #Alistipes, Odoribacter, and #Barnesiella and decreased proportions of #Lachnoclostridium were present in AD elders.
• [1.5] [#Alzheimer’s disease] 
  - #Alistipes, #Barnesiella, and Odoribacter were previously found in symptomatic individuals with AD.
• [1.6] [#Atrial fibrillation, #Pregnancy] 
  - individuals who developed AF had lower abundances of Odoribacter and Sanguibacteroides. - A higher relative abundance of the Odoribacter genus has been related to lower blood pressure in pregnant women.
• [#Hypertension] [#Short Chain Fatty Acid] - Blood pressure is a strong AF risk factor. - Bacteria of the genus Odoribacter odproduce the SCFA acid #Butyrate, a signalling molecule in blood pressure control. - SCFAs interact with G-protein coupled receptor pathways including renin secretion and sympathetic activation,which are central to blood pressure regulation.
• - Odoribacter abundance positively correlates with #Isobutyric acid and an unfavourable lipid profile.
• [1.7] [#Systemic lupus erythematosus] 
  - SLE > increased abundance of genera #Candidatus saccharimonas, #Desulfovibrio, Odoribacter and #Roseburia in mice treated with HCMVpp65 peptide is significantly correlated with lupus-like effects including enhanced levels of creatinine, proteinuria, glomerular damage and anti-dsDNA antibodies.
• [1.8] 
  - A higher genetically predicted abundance Odoribacter was associated with a reduced risk of #Psoriasis. - higher genetically predicted Odoribacter was a lower risk of #Psoriasis vulgaris.
• [1.9] [#Hepatocellular cancer] 
  - increased levels of genus Odoribacter and #Butyricimonas but decreased levels of genus #Dorea in the gut of HCC patients compared to those without HCC and identified them as potential biomarkers of HCC
• - #Sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, #Desulfovibrio, #Escherichia coli, #Fusobacterium, #Klebsiella, #Lactobacillus, #Morganella, Odoribacter, and #Proteus.

References Notes