Ferulic acid {90000124}

Record Keys

Parent:[  ]
Ferulic acid
Queue:[  ]


Initialisation date:
[  ]
[  ]

Meta Information

Structural Type:[  ]
Functional Type:[  ]
Immun regulator


[  ]

Shared Reference Notes

  • [1.1
    - Ferulic acid, a compound known to have antioxidative and immunomodulatory properties
  • [1.2] [#Condition of chronic stress
    - in a model of chronic unpredictable mild stress, ferulic acid ameliorated depressive-like behaviors possibly through the upregulation of #BDNF, postsynaptic protein PSD95 levels, and synapsin I in the prefrontal cortex and hippocampus
  • - Ferulic acid has been shown to have potent implications in #Depression.
  • [#Lipopolysaccharide] - Ligusticum officinale is an anti-inflammatory plant used in oriental medicine which is rich in ferulic acid and potently can attenuate NF-κB activation in BV2 microglial cells following LPS stimulation.
  • - In an outbred ICR mouse model, ferulic acid, in combination with the bioavailability enhancer #Piperine, reduced immobility in the tail suspension and forced swim test by 60% possibly by inhibiting monoamine oxidase activity in the frontal cortex, hippocampus and hypothalamus
  • - ferulic acid at 1 mg/kg reduced #Oxidative stress and neuroinflammatory markers in the blood, hippocampus and cerebral cortex of mice
  • [#Lactobacillus plantarum, #Streptococcus thermophilus] [#Cypto-chlorogenic acid] - mulberry #Anthocyanins were specifically transformed by S. thermophilus (46.2%) and L. plantarum (43.6%) into #Chlorogenic acid, cypto-#Chlorogenic acid, #Caffeic acid and ferulic acid: all #Phenolic acids with potent anti-inflammatory benefits.
  • - Ferulic acid is a #Hydroxycinnaminic acid produced as a microbial metabolite from several #Lactobacillus species and the production of many of its bioactive metabolic products (#Dihydroferulic acid or #Vanillic acid) is dependent on the gut microbiota.
  • [1.3] [#Depression, #Stroke, #Transient Ischemic Attack
    - ferulic acid is known to be metabolized by gut microbes. - It exerts neuroprotective effects by reducing neuronal cell death and recovers memory deficits in a cerebral ischemia and reperfusion injury model. - It has also ameliorated depressionlike behavior and #Oxidative stress.
  • [1.4] [#Alzheimer’s disease, #Amyotrophic lateral sclerosis, #Multiple Sclerosis, #Parkinson’s Disease
    - Ferulic acid (FA), which occurs naturally as the feruloylated #Sugar ester in grains, fruits, and vegetables, is critical for combating #Oxidative stress and alleviating neurodegenerative diseases resulting from free radical-generated protein aggregates in brain cells. - Ferulic acid esterases (FAE) of the gut microbiota are critical enzymes that facilitate FA release from feruloylated #Sugar ester conjugates and influence systemic health.

References Notes

[  ]

Common References

MetaBiom only uses strictly necessary session cookies to give you the best possible experience on the website. By selecting "Accept essential cookies" you agree to the use of these cookies.