Lactic acid {90000433}

Shared Reference Notes

• [1.1] [#Limosilactobacillus (Lactobacillus) reuteri] [#UV radiation] 
  - Lactic acid secreted by Lactobacillus reuteri DSM 17,938 can protect skin from UVB by suppressing pro-inflammatory #IL-6 and IL-8 cytokines.
• [1.2] [#Inflamatory bowel disease] 
  - Patients with IBD have lower fecal levels of #Acetate, #Propionate and #Butyrate, and higher levels of lactic and #Pyruvic acids than healthy individuals
• [1.3] [#Obesity] [#Olive] 
  - in humans, EVOO has prebiotic effects, promoting the growth of beneficial bacteria such as #Lactobacillus and #Bifidobacterium. Specifically, a #Mediterranean diet supplemented with 40 g/day EVOO for 3 months administered to 18 overweight/obese participants resulted in significantly increased levels of lactic acid bacteria compared to baseline.
• [1.4] [#Escherichia coli] 
  - Lactic acid bacteria, such as #Lactobacilli and #Bifidobacteria, which can enhance the production of mucin in human IECs and cause hinderance for the invasion of enteropathogenic E. coli
• [1.5] [#Aromatic amino acid] 
  - #Bifidobacterium species is the main producers of aromatic lactic acids in #Infants’ gut
• [1.6] [#Parkinson’s Disease] 
  - The enrichment of #Lactate production pathway is consistent with the increase of lactic acid bacteria (LAB) in PD patients
• [1.7] 
  - The #Kombucha microbiota, was mainly comprised of lactic acid bacteria, #Acetic acid bacteria, and yeast,
• [1.8] [#Normal Vaginal condition] 
  - Type 5 is dominated by #Lactobacillus jensenii which produces antimicrobial bacteriocins and D-lactic acid. - It’s rare but associated with good health, found in less than 10% of vaginas in research studies.
• [1.9] 
  - #Bifidobacteria can ferment fibre and produce the metabolites #Acetic acid, lactic acid, B vitamins and antibacterial molecules, making it an ideal choice for a #Probiotic
• - #lactulose exerts its beneficial effects on #Hepatic encephalopathy through different pathways. - First, the product of #lactulose fermentation is lactic acid, which is able to reduce the colonic lumen pH by releasing H+. - The #Ammonia in the gut reacts with proton and produces ammonium. This conversion develops a concentration gradient that increases the amount of #Ammonia reuptake from the blood into the gastrointestinal tract. - Second, in the presence of #lactulose in the gastrointestinal tract, the bacteria utilize the energy of #lactulose fermentation instead of the conversion of amino acids to #Ammonia energy. - Third, #lactulose can inhibit glutaminase and prevent the production of #Ammonia from #Glutamine. - Finally, #lactulose shortens the colonic transit time. Thus, it can reduce the level of #Ammonia in the gastrointestinal tract.
• [#Lactobacillus] [#Flavonoid] - flavanols can stimulate lactic acid bacteria.
• [1.11] 
  - Some oral bacteria belonging to genera #Lactobacillus, #Lactococcus, #Bifidobacterium, #Streptococcus, #Leuconostoc, and #Pediococcus produce lactic acid
• [1.12] [#Genome] 
  - In addition to #Bifidobacterium and #Lactobacillus, our study found a significant enrichment of #Streptococcus, a lactic acid-producing bacteria, in patients with #Ulcerative Colitis (UC). - This is in contrast to the majority of earlier studies from west. - This increase in #Streptococcus abundance has also been observed in UC patients from different populations.
• [#Ulcerative Colitis] [#Short Chain Fatty Acid] - A significant loss of SCFA-producing microbes and the concurrent increase in #Nitrate-reducing bacteria in UC patients favor a shift towards a proinflammatory microbiome > enrichment of lactic acid-producing bacteria is a consequence of increased inflammation.
• [1.13] 
  - aerobic glycolysis and lactic acid production are principal features of astrocytes. - astrocyte-derived lactic acid is assimilated by the neurons and re-converted to pyruvic acid to drive the mitochondrial respiratory chain.
• [1.14] 
  - Othe peptide antimicrobials include the #Colicins of #Escherichia coli, the #Pyocins of #Pseudomonas aeruginosa, the #Halocins of #Halobacteria, #Subtilin of #Bacillus subtilis, the #Lantibiotics of lactic acid bacteria (LAB), and other #Bacteriocins.
• [1.15] [#Cancer] [#Probiotic] 
  - similar L-#Lactate-producing lactic acid #Bacteria commensal to other body sites are also significantly associated with survival in colorectal, lung, head and neck, and skin cancers.
• [#Cancer] [#Probiotic] - that lactic acid bacteria in the tumor microenvironment can alter tumor metabolism and #Lactate signaling pathways, causing therapeutic resistance.
• - an obligate L-#Lactate-producing lactic acid bacterium found in tumors, #Lactobacillus iners, is associated with decreased survival in patients, induces chemotherapy and radiation resistance in #Cervical cancer cells, and leads to metabolic rewiring, or alterations in multiple metabolic pathways, in tumors.
• [1.16] 
  - #Lactococcus produces several antimicrobial substances, including lactic acid, #Hydrogen peroxide
• - #Lactococcus > excellent #Lactose-fermenting bacteria breaks down #Lactose to produce lactic acid, which is particularly beneficial for individuals with #Lactose intolerance
• [1.17] 
  - #Copper beads > #Enterobacteriaceae (EB) increased, while lactic acid bacteria (LAB) decreased during the treatment period. - When beads were removed from the feed, EB and LAB concentrations returned to baseline. - #Copper bead supplementation > increase in #Firmicutes, #Euryarchaeota, and #Acidobacteriota, while at the genus level, an increase in #Methanosphaera and #Pseudomonas was observed.

References Notes