mRNA vaccine {51111456}

Shared Reference Notes

• [1.1] 
  - Certain #Butyrate producers, such as #Lachnospira, #Catenibacterium, and #Faecalibacterium, were enriched in individuals with higher immunogenic responses to the BNT162b2 vaccine
• - #Methanobrevibacter, #Ruminococcaceae #DTU089, #Marvinbryantia, #Cloacibacillus, and #Succinivibrio were enriched in the baseline microbiome of individuals with low IgG titers and low spike-specific CD4+ T-cell responses.
• [#Covid-19] - #Agathobacter, #Lactobacillus, #Bacteroides, and #Lachnospira were positively correlated with both spike IgG levels and spike-specific CD4+ T-cell responses. These #Bacteria with known immunomodulatory properties could contribute to higher immune responses to vaccinations
• [#Covid-19] [#Bifidobacterium adolescentis] - B. adolescentis was also associated with a higher rate of neutralizing antibodies after CoronaVac immunization
• [#Covid-19] - #Bifidobacterium and #Faecalibacterium showed significant association with high spike IgG titers, irrespective of other factors - Enrichment of #Bifidobacterium was correlated with CD4+ T-cell responses and higher antibody titers to parenteral and oral vaccinations.
• [#Covid-19] - high spike IgG levels, with less abundance of bacterial groups belonging to #Clostridiales and #Methanobacteriales, such as #Ruminococcaceae #DTU089 and #Methanobrevibacter, respectively.
• [#Covid-19] [#Roseomonas mucosa] [#Short Chain Fatty Acid] - different bacterial groups from #Lachnospiraceae to be associated with either high or low spike IgG levels. - bacterial members belonging to the family #Lachnospiraceae are well-known producers of SCFAs in colon mucosa-associated microbiota. - #Lachnospiracea FSC020, which shows a positive association with spike IgG levels > a potential positive association with the production of #Acetate and propionat
• [#Covid-19] [#Short Chain Fatty Acid] - #Marvinbryantia was observed to be less abundant in the younger group. - enrichment of #Marvinbryantia spp., which are SCFA-producers, in the elderly > a lower response to vaccinations,
• [#Covid-19] - Elevated levels of spike-specific CD4+ T-cell responses were associated with reduced microbiome diversity, thus further validating the association of the microbiome with the immunogenicity of the BNT162b2 mRNA vaccine. - certain bacterial genera at the baseline were associated with vaccine immunogenicity, measured by IgG spike and spike-specific CD4+ T-cell responses.
• - Microbiota-derived #Flagellin, #Peptidoglycan, and #Lipopolysaccharide can act as natural adjuvants to vaccination, recognized by PRRs

References Notes