Fusobacteriaceae ⇒ Fusobacterium {10000597}

Shared Reference Notes

• [1.1] [#Probiotic (Bifidobacter and Lactobacilus)] 
  - Bacteria present in probiotics, particularly the common Lactobacillus and Bifidobacterium microbes, have been found to induce anti-#Cancer action by enhancing #Cancer cell apoptosis and protecting against oxidative stress. - Probiotics supplements also decrease the #Cancer-producing microorganism Fusobacterium.
• [1.2] [#Inflamatory bowel disease] [#Escherichia coli] 
  - Patients with IBD typically have a far less diverse intestinal microbiota than healthy people, as well as an increase in pro-inflammatory bacteria like Enterobacteriaceae, especially E. coli and Fusobacterium. - At the same time, bacteria that generate butyrate, an essential molecule for intestinal and immune health, are declining
• [1.3] 
  - Fusobacterium, utilizes different pathways like those for Glutamate (4-aminobutyrate) and Lysine for #Butyrate production, which are associated with a release of harmful byproducts like ammonia.
• [1.4] [#Periodontal disease] 
  - Transplantation of periopathogenic microbiota from the SP patients altered the caecal microbiota and induced low-grade intestinal inflammation in mice. - The abundance of #Porphyromonadaceae and Fusobacterium, which are co-pathogens in periodontitis and intestinal inflammation was significantly enriched in the gut of the C-SP group. - Interestingly, #Porphyromonadaceae was also enriched in the salivary samples from the humans, revealing the close relationship between the salivary and gut microbiota.
• [1.5] [#Diabetes Type 1, #Diabetes Type 2] 
  - Compared to the levels in non-diabetic individuals, diabetes patients exhibited a higher abundance of #Neisseria, TM7, #Gemella, #Eikenella, #Selenomonas, #Actinomyces, #Capnocytophaga, Fusobacterium, #Aggregatibacter, #Veillonella, and #Streptococcus genera and a lower abundance of Filifactor, Synergistetes, Tannerella, Eubacterium, Porphyromonas, and Treponema genera
• [1.6] [#Parvimonas micra] 
  - grade 3 tumors #Colorectal cancer were significantly enriched in Fusobacterium and #Parvimonas - #Parvimonas micra and Fusobacterium have been shown to aggregate and form biofilms in vitro. - Biofilm formation is linked to inflammatory bowel disease and CC.
• [1.7] [#Fusobacterium varium] 
  - #Lachnospiraceae bacterium and members of #Ruminococcus and Fusobacterium species, including Fusobacterium ulcerans and Fusobacterium varium, were found to be enriched in patients with #Obesity
• [1.8] 
  - Anaerobes such as #Actinomyces, #Veillonella and Fusobacterium are less prevalent in Oral mucos and mostly present at subgingival sites
• [1.9] [#Akkermansia muciniphila, #Faecalibacterium prausnitzii] 
  - in #Colorectal cancer > the relative abundances of Fusobacterium, #Porphyromonas and A. muciniphila are increased, and F. prausnitzii is decreased compared to healthy controls.
• [#Oesophageal adenocarcinoma] - adenocarcinoma has a distinct dysbiosis with a relative abundance of Fusobacterium, #Gemella, #Porphyromonas, and #Parvimonas
• [1.11] [#Bipolar disorder] 
  - low abundance of #Faecalibacterium, #Pseudomonas and Fusobacterium in depressed BD patients may have implications for the neurobiology of BD
• - abundance of #Faecalibacterium, #Pseudomonas and Fusobacterium was negatively correlated with the severity of #Depression.
• - Fusobacterium, which belongs to the #Fusobacteria phylum, was also identified as one of the potential #Butyrate producers, which could modulate the gut microbiota and even modify anti-inflammatory, tumor-fighting, and metabolic pathways
• [1.12] [#Metabolic syndrome] 
  - An abundance of Fusobacterium is involved in promoting inflammation and increasing gut barrier permeability in metabolic disorders
• [#Polycystic ovary syndrome] [#Bacteroides fragilis, #Escherichia coli] - In patients with PCOS, there were enrichment of Fusobacterium, #Escherichia, and #Bacteroides at the genus level and #Bacteroides fragilis and #Escherichia coli at the species level.
• [#Polycystic ovary syndrome] - Fusobacterium has also been observed to be enriched in the oral microbiota of PCOS patients.
• [1.13] [#Fusobacterium nucleatum] 
  - A high abundance of Fusobacterium (in particular F. nucleatum) at #Colorectal cancer sites has been associated with regional lymph node metastases and tumor location (2% in rectum and approx. 11% in cecum)
• [#Oral squamous cell carcinoma] - Oral cancer and epithelial precursor lesions are also linked with bacteria from genera Fusobacterium, #Veillonella, #Actinomyces, #Clostridium, #Haemophilus, and #Enterobacteriaceae
• [1.14] [#Pulmonary tubercolosis, #Tuberculosis] 
  - The genera #Parabacteroides, #Bacteroides, #Lachnoclostridium, and Fusobacterium were markedly enhanced in the PTB group, while #Roseburia, #Blautia, unidentified #Ruminococcaceae, #Bifidobacterium, #Romboutsia, and #Fusicatenibacter were enhanced in the HC group.
• [1.15] 
  - Patients with #Melanoma had a higher relative abundance of Fusobacterium compared with controls on univariate analysis
• [1.16] 
  - #Sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, #Desulfovibrio, #Escherichia coli, Fusobacterium, #Klebsiella, #Lactobacillus, #Morganella, #Odoribacter, and #Proteus.
• - Fusobacterium and #Peptostreptococcus were the most consistently increased genera among the #Cancer cases
• [1.17] 
  - levels of #TMAO in cystic fluid were positively correlated with bacterial clusters corresponding to Enterobacteriacea, #Granulicatella, #Klebsiella, #Stenotrophomonas, #Streptococcus, #Haemophilus, and Fusobacterium > associated with #Pancreatic Cancer.
• [1.18] [#Colorectal cancer] [#Fusobacterium necrophorum] 
  - Fusobacterium necrophorum (F. necrophorum), another member of the Fusobacterium genus with an invasive behavior88, has also been associated with CRC
• [#Oral squamous cell carcinoma] - the genera #Parvimonas, #Peptoniphilus and Fusobacterium were most abundant in an #Oral cancer subtype, OSCC
• [1.19] [#Clostridium difficile associated disease, #Clostridium difficile infection] 
  - patients who are likely to develop R-CDI have higher levels of #Calprotectin, together with a higher abundance of Fusobacterium and lower abundance of #Senegalimassilia, #Prevotella and #Ruminococcus.
• [#Clostridium difficile associated disease] - Fusobacterium increased in abundance, while #Collinsella, #Senegalimassilia, #Prevotella and #Ruminococcus decreased in patients with recurrent versus non-recurrent disease.
• [#Polycystic ovary syndrome] - Women suffering from PCOS had increased levels of Fusobacterium and decreased levels of #Actinobacteria in their salivary microbiomes
• [1.21] [#Moyamoya disease] 
  - the relative abundance of the 2 genera, #Lachnoclostridium and Fusobacterium, increased in the MMD group, while the relative abundance of the 2 genera, #Bifidobacterium and #Enterobacter decreased in the MMD group.
• [1.22] [#Helicobacter pylori] 
  - reduced levels of #Nesterenkonia but increased levels of #Methylophilaceae, Fusobacterium, #Prevotella, #Actinomyces, #Novosphingobium, and H. pylori in #Extrahepatic Cholangiocarcinoma cases.
• [1.23] [#Colorectal cancer] 
  - #Akkermansia and #Bacteroides emerged as notable microbes enriched in yoCRC tumors as compared to Bacillus, #Staphylococcus, #Listeria, #Enterococcus, #Pseudomonas, Fusobacterium, and #Escherichia/#Shigella which have consistently been implicated with higher relative abundance in aoCRC tumors
• [#Colorectal cancer] - CRC tumors, particularly in patients with metastatic disease, were relatively enriched with the Fusobacterium genus
• [1.24] 
  - #Lichtheimia, a fungal species, has demonstrated a constructive relationship with bacterial species such as #Campylobacter, #Porphyromonas, and Fusobacterium.
• [1.25] [#Multiple Sclerosis] 
  - the abundance of Fusobacterium increased in the gut as it did in the saliva.
• [#Multiple Sclerosis] - Fusobacterium and #Leptotrichia had an increased abundance in the MS oral microbiota.
• [1.26] [#Schizophrenia] 
  - Megasphera, #Akkermansia, Fusobacterium and #Prevotella were significantly more abundant in SCZ patients, and #Citrobacter, #Blautia, #Coprococcus, #Lachnoclostridium were more abundant in HC controls.
• [1.27] [#Non-small-cell lung cancer] [#Immune checkpoint inhibitor] 
  - presence of Fusobacterium was negatively associated with responsiveness to ICB treatment in NSCLC. - Fuso-high tumors had significantly lower cytotoxic, IFNG, and major histocompatibility complex (MHC) class II gene expression signatures

References Notes