Sugar {51111159}

Record Keys

Queue:[  ]


Initialisation date:
[  ]

Meta Information

Diet, Habit
Zone:[  ]


[  ]

Shared Reference Notes

  • [1.1
    - The abundance of the mucus-degrading bacteria Akkermansia muciniphila and Bacteroides fragilis was increased. - Bacteria-derived mucolytic enzymes were enriched leading to erosion of the colonic mucus layer of sugar-fed mice. - Sugar-induced exacerbation of colitis was not observed when mice were treated with antibiotics or maintained in a germ-free environment, suggesting that altered microbiota played a critical role in sugar-induced colitis pathogenesis.
  • [1.2] [#Ulcerative Colitis] [#Plant-based diet
    - A positive association between a “high sugar and soft drinks” pattern and UC risk - When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.
  • [1.3] [#Inflamatory bowel disease
    - A sugar-rich diet favors the increase of #Akkermansia muciniphila, a mucolytic bacterium. The mucus layer separates luminal bacteria from intestinal epithelium: A thinner mucus layer allows bacteria to come in contact with the epithelial cells, eliciting an inflammatory response.
  • - A sugar-rich diet increases the percentage of pro-inflammatory Sutterellaceae and Marinilabiliaceae, which induce bowel inflammation, and reduce bacteria with anti-inflammatory properties like Lachnospiraceae and Lactobacillaceae, able to produce the short-chain fatty acid (SCFA) butyrate, the main anergy source of enterocytes.
  • [1.4
    - #Butyrate inhibits gut microbiome #Bacteroides - #Butyrate inhibition depends on which sugar a given #Bacteroides strain uses - Core genome variation in Acyl-CoA enzymes mediates #Butyrate defense - Each #Bacteroides unique fitness landscape unpredictable by interaction of ecosystem parts
  • [1.5] [#Prediabetes] [#High Fat Diet
    - microbiota protects against development of #Obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of sugar. - Eliminating sugar from high-fat diets protected mice from #Obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota.
  • [1.6] [#Mediterranean Ketogen Diet
    - MMKD had higher relative abundances of dietary metabolites found in high-fat dairy products, including cheddar cheese, low-sugar fruits like cherries, and low-sugar vegetables including #Broccoli
  • [1.7
    - high sugar conditions directly limit murine and human colonoid development, which is associated with a reduction in the expression of proliferative genes, ATP levels and the accumulation of #Pyruvate. - Treatment of colonoids to force #Pyruvate into the #Tauro-cholic acid cycle, restored their growth. - high sugar diet led to massive irreparable damage that was independent of the colonic microbiota and its metabolites. Analyses on crypt cells.
  • [1.8] [#Carbohydrate diet
    - carbohydrate-rich diets, including dietary fiber and simple sugars, belong to the #Prevotella enterotype.
  • [1.9] [#Diabetes Type 2
    - despite the sugar used in the fermentation process of #Kombucha, daily consumption did not raise #Fasting blood glucose levels to unhealthy levels in diabetics.
  • [#Prevotella copri] [#Western-style diet] - The Western diet is a high-fat, high-sugar, and low-fiber die significantly reduced the abundance of P. copri.
  • [1.11] [#Attention Deficit Hyperactivity Disorder
    - sugar restriction alone does not improve ADHD
  • [1.12] [#Diabetes Type 2] [#Sugar-sweetened beverage
    - high intake of sugar-sweetened carbonated beverage (SSCB) was more associated with the prevalence of #Depression. - the risk of depressive symptom significantly increased proportionally to SSCB consumption. - The effects appeared to be the same between those with pre-diabetic risk and those with normal blood sugar — which suggests insulin resistance or blood sugar levels don’t appear to play a part in determining risk for #Depression symptoms.
  • [1.13] [#Oscillibacter valericigenes] [#High Fat Diet
    - expansion of O. valericigenes > mice fed a high fat, high sugar diet > inflammatory macrophages with a very similar signature in the adipose tissue.
  • [1.14] [#Alzheimer’s disease, #Amyotrophic lateral sclerosis, #Multiple Sclerosis, #Parkinson’s Disease
    - #Ferulic acid (FA), which occurs naturally as the feruloylated sugar ester in grains, fruits, and vegetables, is critical for combating #Oxidative stress and alleviating neurodegenerative diseases resulting from free radical-generated protein aggregates in brain cells. - #Ferulic acid esterases (FAE) of the gut microbiota are critical enzymes that facilitate FA release from feruloylated sugar ester conjugates and influence systemic health.
  • [1.15] [#Akkermansia muciniphila] [#Sugar-sweetened beverage
    - sweet consumption was positively associated with the prevalence of A. muciniphila.
  • [1.16
    - feeding dietary simple sugars like #Glucose and #Fructose would enhance the abundance of #Akkermansia.
  • [#Depression, #Schizophrenia] - Dietary sugars, like #Fructose and #Glucose, are associated with psychosis-related higher brain dysfunction

References Notes

[  ]

Common References

MetaBiom only uses strictly necessary session cookies to give you the best possible experience on the website. By selecting "Accept essential cookies" you agree to the use of these cookies.