Disease ⇒ Hepatocellular cancer {40000356}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Hepatocellular cancer

Details
Initialisation date:	[ ]
Other Terms:	HCC

Meta Information
MedDra ID:	10073071
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

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Shared Reference Notes

[1.1]
- Immune reactivity against E. hirae or B. longum also correlates with robust CD8+ T cell responses and better prognosis in HBV-related hepatocellular carcinoma
[1.2]
- hepatocellular carcinoma patients had significantly decreased #Linoleic acid and #Phenol levels in serum and feces, two metabolites that significantly inhibit the growth of hepatocellular carcinoma cells.
[1.3]
- Coprococcus and Faecalibacterium were depleted in hepatocellular carcinoma.
[1.4]
- #Fusobacterium nucleatum was found to directly interact with TIGIT through the FAP2 protein, with subsequent inhibition of NK cells which have significant anti-tumor properties
[1.5] [#Secondary bile acids]
- excessive production of the secondary BA deoxycholic acid triggers the expression of inflammatory and tumorigenic factors in hepatic stellate cells (HSCs), contributing to hepatocellular carcinoma development. Secondary BAs might also activate farnesoid X receptor (FXR) and elevate the risk of developing #Colorectal cancer and hepatocellular carcinoma.

References Notes

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↥ Microbiota

‐ Acidaminococcus Stool Human [1.6]
‐ Actinobacteria Stool Human [1.6]
‐ Actinobacteria Tongue scrape sample Human [1.7]
‐ Actinomyces Tongue scrape sample Human [1.7]
‐ Akkermansia Stool Human [1.6]
‐ Alistipes Stool Human [1.6]
‐ Allisonella Stool Human [1.6]
‐ Alloprevotella Stool Human [1.8]
‐ Anaerostipes Stool Human [1.6]
‐ Anaerotruncus Stool Human [1.6]
‐ Bacteroides Stool Human [1.9]
‐ Barnesiella Stool Human [1.8]
‐ Bilophila Stool Human [1.10]
‐ Butyricicoccus Stool Human [1.6]
‐ Campylobacter Tongue scrape sample Human [1.7]
‐ Clostridium cluster IV Stool Human [1.6]
‐ Clostridium cluster XIVb Stool Human [1.6]
‐ Clostridium Stool Human [1.6]
‐ Collinsella Stool Human [1.6]
‐ Coprococcus Stool Human [1.6]
‐ Dorea Stool Human [1.6]
‐ Eggerthella Stool Human [1.6]
‐ Enterococcus Stool Human [1.10]
‐ Epsilonproteobacteria Tongue scrape sample Human [1.7]
‐ Erysipelotrichia Stool Human [1.6]
‐ Escherichia coli Stool Human [1.11]
‐ Eubacterium Stool Human [1.6]
‐ Faecalibacterium Stool Human [1.8]
‐ Fusobacterium Tongue scrape sample Human [1.7]
‐ Gemella Stool Human [1.10]
‐ Gemmiger Stool Human [1.6]
‐ Holdemania Stool Human [1.6]
‐ Lachnospiraceae Tongue scrape sample Human [1.7]
‐ Lachnospira Stool Human [1.6]
‐ Leptotrichia Tongue scrape sample Human [1.7]
‐ Odoribacter Stool Human [1.6]
‐ Oscillibacter Stool Human [1.6]
‐ Parabacteroides Stool Human [1.6]
‐ Paraprevotella Stool Human [1.6]
‐ Phascolarctobacterium Stool Human [1.10]
‐ Phenylobacterium Stool Human [1.9]
‐ Porphyromonas Stool Human [1.6]
‐ Prevotella Stool Human [1.8]
‐ Proteobacteria Stool Human [1.9]
‐ Proteus Stool Human [1.8]
‐ Pseudomonas Stool Human [1.6]
‐ Pyramidobacter Stool Human [1.6]
‐ Ruminiclostridium Stool Human [1.8]
‐ Ruminococcaceae Stool Human [1.8]
‐ Ruminococcus Stool Human [1.6]
‐ Shigella Stool Human [1.8]
‐ Streptococcus Stool Human [1.10]
‐ Subdoligranulum Stool Human [1.8]
‐ Synechococcus Stool Human [1.9]
‐ Veillonella Stool Human [1.8]

↧ Microbiota

‐ Acidaminococcus Stool Human [1.6]
‐ Adlercreutzia Stool Human [1.10]
‐ Aggregatibacter Stool Human [1.6]
‐ Akkermansia Stool Human [1.10]
‐ Bacteroidetes Tongue scrape sample Human [1.7]
‐ Bifidobacterium Stool Human [1.10]
‐ Collinsella Stool Human [1.10]
‐ Coprobacillus Stool Human [1.6]
‐ Coprococcus Stool Human [1.3]
‐ Dialister Stool Human [1.10]
‐ Enterococcus Stool Human [1.6]
‐ Faecalibacterium Stool Human [1.3]
‐ Gammaproteobacteria Tongue scrape sample Human [1.7]
‐ Haemophilus Stool Human [1.6]
‐ Haemophilus Tongue scrape sample Human [1.7]
‐ Klebsiella Stool Human [1.6]
‐ Lactobacillus Stool Human [1.6]
‐ Megasphaera Stool Human [1.6]
‐ Pasteurellaceae Tongue scrape sample Human [1.7]
‐ Peptococcus Stool Human [1.6]
‐ Phascolarctobacterium Stool Human [1.6]
‐ Pseudomonas Tongue scrape sample Human [1.7]
‐ Rothia Stool Human [1.6]
‐ Streptococcus Tongue scrape sample Human [1.7]

Intervention by Microbiota

[ ]

↥ Metabolome

‐ Secondary bile acids Causal? Gut Inner Mucus Human [1.5]

↧ Metabolome

[ ]

Intervention by Metabolome

[ ]

Related Factor

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Subclass

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References

[ ]

Author: MetaBiom
Identifier: 40000356
URL: https://www.metabiom.org/disease/256/hepatocellular-cancer
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy [2020] [Review] [Oncoimmunology] [Journal] [80001845]
[1.2] Small molecules in the big picture of gut microbiome-host cross-talk - IMPORTANT [2022] [Review] [EBioMedicine] [Journal] [80002422]
[1.3] Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease [2022] [Study] [Frontiers in Microbiology] [Journal] [80002427]
[1.4] Hepatocellular Carcinoma: Understanding the Inflammatory Implications of the Microbiome [2022] [Review] [International journal of molecular sciences] [Journal] [80002481]
[1.5] The double-edged sword of probiotic supplementation on gut microbiota structure in <i>Helicobacter pylori</i> management [2022] [Gut microbes] [Journal] [80002569]
[1.6] Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma [2018] [Gut] [Journal] [80000859]
[1.7] Deep sequencing reveals microbiota dysbiosis of tongue coat in patients with liver carcinoma [2016] [Scientific Reports] [Journal] [80001032]
[1.8] Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma [2019] [Gut Pathogens] [Journal] [80000945]
[1.9] Gut microbiota dysbiosis in patients with hepatitis B virus-induced chronic liver disease covering chronic hepatitis, liver cirrhosis and hepatocellular carcinoma [2020] [Journal of Viral Hepatitis] [Journal] [80001388]
[1.10] Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease [2018] [Hepatology] [Journal] [80000791]
[1.11] Profile of gut microbiota associated with the presence of hepatocellular cancer in patients with liver cirrhosis [2016] [Transplantation Proceedings] [Journal] [80000772]

Disease ⇒ Hepatocellular cancer {40000356}

Record Keys

Details

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References