Sulfur {90000380}

Shared Reference Notes

• [1.1] 
  - #Desulfovibrio is a sulfur-reducing bacteria (SRB) that can degrade mucins, SCFAs, and amino acids (glutamate, alanine) in the human colon, and may help to maintain the integrity of the gut epithelium.
• [1.2] [#Natural Skin Microbiome] 
  - pathogenic microbes actively metabolizing in the #Clay were absent. Importantly, 6% of the transcripts annotated to sulfur and iron metabolism, which are known to play a major role in skin disease management.
• [1.3] 
  - imbalances in functional pathways indicative of dysbiosis were associated with reduced predicted age and elevated risk of #Allergy. -These included a breakdown of mucous integrity via elevated sulfur reduction and diminished sulfur oxidation pathways, elevated oxidation levels and subsequent availability of oxidized monosaccharides, as well as reduced potential for secondary fermentation.
• [1.4] 
  - Some oral #Bacteria (e.g., #Porphyromonas gingivalis, #Prevotella intermedia, #Aggregatibacter actinomycetemcomitans, and #Fusobacterium nucleatum) produce volatile sulfur compounds (VSCs), such as #Hydrogen sulfide (H2S), methyl mercaptan (CH3SH), dimethyl #Sulfide ((CH3)2S), and dimethyl disulfide (CH3SSCH3).
• - volatile sulfur compounds (VSCs) are toxic to tissues and play a role in the pathogenesis of periodontitis and in the development of chronic inflammation.
• [1.5] 
  - sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, #Desulfovibrio, #Escherichia coli, #Fusobacterium, #Klebsiella, #Lactobacillus, #Morganella, #Odoribacter, and #Proteus.
• - sulfur-metabolizing microbiome in the human gut has been shown to be associated with a high risk of #Colorectal cancer
• [1.6] 
  - #Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen #Bilophila wadsworthia in its sulfur metabolism pathways and host distribution.
• [#Taurinivorans muris] - Colonization of T. muris in gnotobiotic mice increased deconjugation of #Taurine-conjugated #Bile Acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of #Salmonella enterica
• [1.7] 
  - #Hydrogen sulfide (H2S) and methanethiol are produced during the decomposition of sulfur-containing amino acids, and have been linked to the progression of #Chronic kidney disease (CKD), cardiovascular disease, and bone metabolic disorders
• - Sulfur-containing amino acids can be fermented by Enterobacteria, #Enterococci, Peptostreptococci, #Fusobacteria, and #Eubacteria
• [1.8] 
  - genes involved in #Iron binding and #Iron-sulfur cluster binding were increased in the livers of infected mice, but suppressed by #Nisin treatment
• [1.9] [#Parkinson’s Disease] [#Akkermansia muciniphila, #Bilophila wadsworthia] 
  - in PD > changes in sulfur metabolism, driven by A. muciniphila and B. wadsworthia, which is consistent with the changed metabolome.
• [#Atopobium vaginae, #Gardnerella vaginalis, #Solobacterium moorei] [#Diet Inflammatory Index] - Higher DII scores were associated with the enrichment of pro-inflammatory bacterial species, including S. moorei, a producer of pro-inflammatory sulfur compounds, and those associated with inflammatory perinatal conditions such as #Preterm birth and GDM, including G. vaginalis, A. vaginae and members of the #Corynebacterium genera
• [1.11] [#Multiple Sclerosis] 
  - an increased ratio of #Cysteine persulfide to #Cysteine in SPMS revealed by sulfur metabolomics > excessive DNA oxidation could take place in the gut of secondary progressive MS (SPMS).

References Notes