Sleep Deprivation {51111282}
Factor: | Sleep Deprivation |
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Queue: | [ ] |
Initialisation date: | 2022-01-25 |
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Specification: | |
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Type: | Habit |
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Host: | Mouse |
Zone: | [ ] |
Notes:
[ ]
Shared Notes
- [1.1]
- gut microbial composition and metabolites did not change in the rats after 24 h of SD but were significantly altered after 48 h of Sleep Deprivation > reversible after 1 week of sleep recovery.
- After 48 h of SD, the relative abundance of Butyricicoccus, Butyricimonas, Alistipes, Intestinimonas, and Lactobacillus decreased, whereas the relative abundance of Streptococcus increased.
- - fecal butyrate concentrations positively correlated with the relative abundance of Butyricimonas.
- the abundance of SCFAs-producing microbes, such as Butyricicoccus, Butyricimonas, and Alistipes markedly decreased after SD.
- butyrate > significantly reduced after 48 h of SD > After 1 week of sleep recovery, butyrate concentrations returned. - - Streptococcus was negatively correlated with the concentration of fecal butyrate and positively correlated with the KEGG pathway of lipopolysaccharide biosynthesis.
- [1.2]
- Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation.
- Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
- sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum.