Sleep Deprivation {51111282}

Shared Notes

• [1.1] 
  - gut microbial composition and metabolites did not change in the rats after 24 h of SD but were significantly altered after 48 h of Sleep Deprivation > reversible after 1 week of sleep recovery.
  - After 48 h of SD, the relative abundance of Butyricicoccus, Butyricimonas, Alistipes, Intestinimonas, and Lactobacillus decreased, whereas the relative abundance of Streptococcus increased.
  
  
• - fecal butyrate concentrations positively correlated with the relative abundance of Butyricimonas.
  - the abundance of SCFAs-producing microbes, such as Butyricicoccus, Butyricimonas, and Alistipes markedly decreased after SD.
  - butyrate > significantly reduced after 48 h of SD > After 1 week of sleep recovery, butyrate concentrations returned.
• - Streptococcus was negatively correlated with the concentration of fecal butyrate and positively correlated with the KEGG pathway of lipopolysaccharide biosynthesis.
• [1.2] 
  - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation.
  - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
  - sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum.