Microbiome & Chronic Diseases

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Sleep Deprivation {51111282}

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Sleep Deprivation
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Shared Notes

  • [1.1
    - gut microbial composition and metabolites did not change in the rats after 24 h of SD but were significantly altered after 48 h of Sleep Deprivation > reversible after 1 week of sleep recovery.
    - After 48 h of SD, the relative abundance of Butyricicoccus, Butyricimonas, Alistipes, Intestinimonas, and Lactobacillus decreased, whereas the relative abundance of Streptococcus increased.

  • - fecal butyrate concentrations positively correlated with the relative abundance of Butyricimonas.
    - the abundance of SCFAs-producing microbes, such as Butyricicoccus, Butyricimonas, and Alistipes markedly decreased after SD.
    - butyrate > significantly reduced after 48 h of SD > After 1 week of sleep recovery, butyrate concentrations returned.
  • - Streptococcus was negatively correlated with the concentration of fecal butyrate and positively correlated with the KEGG pathway of lipopolysaccharide biosynthesis.
  • [1.2
    - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation.
    - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
    - sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum.