Disease ⇒ Psoriasis {40000128} Record Keys Type:Disease Parent:[ ] Definition:Psoriasis Details Initialisation date:2020-09-06 Other Terms:[ ] LinksWickipediaMerck Manual Meta Information MedDra ID:10037153 MedDra Level:pt ICD:[ ] Category:Dermatology Zone:[ ] Mechanism:[ ] Notes: - psoriatic lesions tend to have higher Firmicutes, Actinobacteria, and Corynebacterium kroppenstedtii. Both Staphylococci and Propionibacterium were present at lower levels, while Proteobacteria was present at higher levels in psoriasis than in healthy adults. - Among bacterial species with higher abundance in the psoriasis gut microbiome, Bacteroides vulgatus and Parasutterella excrementihominis have been associated with other immune-mediated diseases. - Increased intestinal colonization of Bacteroides vulgatus and elevated Bacteroides vulgatus reactive serum antibodies have been reported in ulcerative colitis patients. - Moreover, colonization of Bacteroides vulgatus is sufficient to promote colitis in several animal models, which further supports the active role of Bacteroides vulgatus in development of colitis. - The abundance of Akkermansia muciniphila was significantly reduced in patients with psoriasis . - A. muciniphila is believed to have an important function in the pathogenesis of IBD and obesity; therefore, A. muciniphila, which is an indicator of health status, may be a key node for psoriasis as well as IBD and obesity. (1) Shared Reference Notes [1.1] - Altered gut barrier in psoriasis is associated with gastrointestinal symptoms, systemic inflammatory profile and the increased blood concentration of gut microbiota-derived metabolite – TMAO. [1.2] - Biologic therapy may have an impact on the composition of the gut microbiome of psoriatic patients. [1.3] [#Multiple Sclerosis] - Orally administered EDP1867, a gamma-irradiated strain of #Veillonella parvula, rapidly transits through the murine gut without colonization or alteration of the background microbiome flora. - In murine models of inflammatory disease including delayed-type hypersensitivity (DTH), #Atopic Dermatitis, psoriasis, and experimental autoimmune encephalomyelitis (EAE), treatment with EDP1867 resulted in significant reduction in inflammation and immunopathology. [1.4] [1.5] [#Akkermansia muciniphila] - abundance of A. muciniphila was significantly decreased in patients with psoriasis. - In patients with moderate-to-severe psoriasis, serum markers of intestinal barrier integrity injury increased. - intestinal fatty acid binding protein, a biomarker of intestinal barrier damage, significantly elevated in patients with psoriasis. [1.6] [1.7] [1.8] - patients with psoriasis have a higher abundance of Proteobacteria and S. aureus and a decrease in Acinetobacter when compared to healthy individuals [1.9] [#Acute anterior uveitis, #Ankylosing spondylitis, #Crohn’s disease, #HLA-B27-associated disease, #Psoriatic Arthritis, #Ulcerative Colitis] - HLA-B27 transgenic rats that develop a spontaneous spondyloarthropathy-like illness do not develop disease when raised in a germ-free environment, but mono-association with #Phocaeicola vulgatus is sufficient to induce disease. [#Acne] [1.11] - #Kocuria and #Cutibacterium were enriched in healthy subjects, while #Staphylococcus was enriched in psoriatic disease. - The relative abundance of #Corynebacterium was higher in NL #Psoriatic Arthritis (PsA). samples compared with NL psoriasis (PsO) samples. [1.12] [#Oleic acid, #Stearic acid] - administration of oleic and stearic acids exacerbated psoriasis-like symptoms: [#Oleic acid, #Stearic acid] - mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of #Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids. - #Gentamicin treatment significantly reduced the abundance of #Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod (IMQ)-induced psoriasis-like mice. [1.13] [#Antimicrobial peptides] - HDPs are well-known for their immunomodulatory and barrier-improving properties and play a critical role in the pathogenesis of diseases such as psoriasis and polymorphic light eruption underscoring the versatile role of HDPs in skin physiology [1.14] [#Allergy, #Diabetes Type 2] - A disturbed #Proteobacteria microbiota has been previously associated with psoriasis, eczema and diabetic foot ulcers, with greater #Proteobacteria diversity correlated with T-helper1, interleukin-10 and anti-inflammatory immune responses that were protective against allergic inflammation. [1.15] [#Pancreatic Cancer] - #Malassezia > new pathogenic roles in #Seborrheic dermatitis, psoriasis, #Crohn’s disease, and pancreatic ductal carcinoma. [1.16] [#Natural Skin Microbiome] - #Firmicutes, #Proteobacteria, and #Actinobacteria as the primary active microbial phyla in Chamliyal #Clay. - These resemble those abundant in a healthy human skin microbiome. - This is significant as lower levels of these phyla in the skin are linked to inflammatory skin conditions like psoriasis. [1.17] [#Bacteroides-Prevotella group] - a higher genetically predicted Atinomycetaceae, #Eubacterium fissicatena group, #Lactococcus, and #Actinomycetales were associated with a higher risk of psoriasis vulgaris. - The genetically predicted relative abundance of #Verrucomicrobiae, #Verrucomicrobiaceae, #Akkermansia, #Verrucomicrobiales were positively associated with arthropathic psoriasis. - A higher genetically predicted abundance #Odoribacter was associated with a reduced risk of psoriasis. - higher genetically predicted #Odoribacter was a lower risk of psoriasis vulgaris. - A higher genetically predicted abundance of #Rikenellaceae served as protective factors for arthropathic psoriasis. - a higher genetically predicted abundance of #Ruminiclostridium 5 was associated with an increased risk of psoriasis. [1.18] - #Resveratrol also targets toll-like receptor (TLR) signalling, such as TLR2, TLR3, and TLR4 signalling.9-13 In skin, #Resveratrol reduces imiquimod-induced, TLR7, TLR8, TLR9-mediated, psoriatic inflammation in animal models, most likely via interfering with NF-kB activation. [1.19] [#Metabolic syndrome] - Psoriasis > #Balneotherapy and thermal water drinkin > increase in #Firmicutes bacterium CAG95 in gut, which was previously identified as the species with the highest association with metabolic health. - the consistent negative association of #Micrococcus and #Aggregatibacter with psoriasis improvement regardless of body site suggests that these genera might serve as biomarkers of a lack of clinical response to treatment. - Both genera are known to cause infections, particularly in immunocompromised individuals, suggesting a potential link between microbiome composition and disease exacerbation. - Psoriasis > #Massilia and #Delftia showed potential as “good taxa,” as they were negatively associated with affected skin before treatment and increased after successful #Balneotherapy. - certain genera, such as #Finegoldia and #Ornithinimicrobium, were enriched on diseased skin at baseline but significantly decreased after #Balneotherapy in patients who reported psoriasis improvement. - Psoriasis > abundance of genera associated with disease or lack thereof and significantly altered after #Balneotherapy showed a trend towards the non-disease condition on the elbows, as for the decreasing #Ornithinimicrobium and #Mesorhizobium. - Psoriasis > an increased relative abundance of #Staphylococcus on the retroarticular crease both on affected and unaffected skin [#Atopic Dermatitis, #Hidradenitis suppurativa] [1.21] [#Diabetes Type 1, #Hashimoto’s thyroiditis, #Sjögren syndrome ] Patients with psoriatic disease had a significantly higher risk of #Crohn’s disease , #Ulcerative Colitis, #Systemic lupus erythematosus, #Rheumatoid Arthritis, #Ankylosing spondylitis , #Alopecia areata, and type 1 diabetes. - the risk of #Graves’ disease, Hashimoto’s disease, Sjögren’s syndrome, and #Systemic sclerosis was not significantly different between the groups. [1.22] [#Faecalibacterium prausnitzii] - F. prausnitzii is a well-known microbiomarker of inflammatory diseases, which has been reported to be reduced in the gut microbiome of #Atopic Dermatitis and psoriasis patients. [1.23] - #Brevibacterium was reported to be predominant in skin samples of psoriatic lesions, #Senile pruritis subjects and on skin of elderly bedridden subjects often presenting #Dry Skin with possible localized infected wounds [1.24] - taxa with potential associations to the risk of psoriasis include #Mollicutes, #Victivallaceae, #Eubacterium coprostanoligenes, #Eubacterium fissicatena, #Holdemania, #Lachnospiraceae NK4A136, #Lactococcus, #Tenericutes. - Certain strains within the #Eubacterium coprostanoligenes possess steroid-metabolizing abilities, participating in #Cholesterol metabolism and converting #Cholesterol into the #Cholesterol degradation product, #Coprostanol. - potential causal relationship between the #Eubacterium coprostanoligenes, #Eubacterium fissicatena, and psoriasis risk. - negative correlation between #Victivallaceae and #Lachnospiraceae NK4A136 group and the risk of psoriasis. - negative correlation between #Lactococcus and the risk of psoriasis. [1.25] [#Acne] [#Ultraviolet Exposure] [1.26] - The psoriatic subject showed a decrease in Firmicutes abundance and an increase in Proteobacteria abundance. - An increase in Streptococcaceae, Rhodobacteraceae, Campylobacteraceae and Moraxellaceae has been observed in psoriatic subject.References Notes[ ]
