Akkermansiaceae ⇒ Akkermansia {10000161}

Shared Reference Notes

• [1.1] 
  -Increased abundance of Akkermansia and Holdemania were found to be predictive of MS. - Akkermansia showed negative associations with the bile acid components taurocholate, bile acid glycocholate and fatty acid anions 3-hydroxyoctanoate and caproate. - The identification of bile acids associated with a number of our taxa is consistent with several studies showing an integral role of the gut bile acid pool as a modulator of host immune response and inflammation
• [1.2] 
  - Akkermansia spp can reduce inflammation by a number of different mechanisms such as reducing plasma level of lipopolysaccharide (LPS)-binding protein (LBP), reducing the expression of inflammatory genes, and reducing the production of pro-inflammatory cytokines such as IL-17, IL-23, IL-8, TNF-α as well as increasing the production of anti-inflammatory cytokines such as IL-10 and IL-12. - While low levels of Akkermansia were found in obesity and type-2 diabetes mouse models, exogenous administration of Akkermansia increased the control of gut inflammation and permeability by regulating tight-junction-related proteins, and thickening the intestinal mucous layer.
• [#High Fat Diet] - The population of Akkermansia in the gut is negatively modulated by the fat content of the consumed diet.
• [#Diabetes Type 2] - The commonly used diabetes treatment #Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
• [1.3] [#Obesity] [#Human breast milk] 
  - Infants fed with breast milk rich in #Betaine showed reduced growth rates after birth. - Experiments in mice showed that giving #Betaine to female mice improved blood sugar metabolism and lowered fat tissue in breastfeeding offspring. - When breast-fed with milk rich in #Betaine, both mouse pups and human infants had higher amounts of Akkermansia bacteria in their guts. - Low levels of maternal #Betaine during pregnancy are linked to increased infant weight at birth. - Maternal #Betaine supplementation resulted in lower fetal weight in a mouse study.
• [1.4] [#Diabetes Type 2] 
  - In a mouse model oral administration of Akkermansia activated toll-like receptor 2, increased the expression of epithelial tight-junction proteins, and reversed high-fat diet-induced insulin resistance - Akkermansia was the only genus that was underrepresented in patients with elevated HbA1c
• [1.5] [#Exercise training] 
  - Exercise increases > increase α-diversity and microbial metabolites such as SCFAs. - Exercise > typically reveal increases in commensal taxa such as #Bifidobacterium, #Lactobacilli, and Akkermansia
• [#High-protein diet] - High-protein group > decreased abundance of #Veillonellaceae, Akkermansia, uncultured #Eggerthellaceae, and #Ruminococcaceae UCG-010
• [1.6] [#Lachnospiraceae] 
  - 4 weeks of #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in #Bifidobacterium and #Dialister at the genus level.
• [1.7] [#Alzheimer’s disease] 
  - Decrease in #Bacteroidetes and #Alloprevotella and increase in #Proteobacteria, #Verrucomicrobia, Akkermansia, and #Desulfovibrio > improve short-term memory ability and cognitive level of AD mice
• [#Parkinson’s Disease] [#Bifidobacterium adolescentis] - PD patients, showing an increase in Akkermansia, Bifidobacterium, and #Lactobacillus and a decrease in #Prevotella
• [1.8] [#Ruminococcaceae] [#High Fat Diet] 
  - HFD > decrease relative abundance of #Verrucomicrobia, Akkermansia , Ruminococcaceae_UCG-014 and #Bifidobacteriaceae
• [#Bifidobacteriaceae, #Ruminococcaceae] [#Moderate Treadmill Exercise] - Exercise > increase the relative abundance of #Verrucomicrobia, Akkermansia and Ruminococcaceae_UCG-014
• [1.9] [#Parkinson’s Disease] 
  - increased relative abundance of the Akkermansia genera over time among individuals with PD across multiple geographic locations (Finland, Germany, Japan, Russia, and United States) - an increase in the relative abundance of genus Akkermansia, a genus of mucin-metabolizing bacteria that are commonly elevated among individuals with PD, in individuals with RBD (REM sleep behavior disorder)
• [#Parkinson’s Disease] - Mucin degrading genus Akkermansia of the phylum #Verrucomicrobia has been widely reported to be significantly abundant in PD by most studies. Akkermansia and Christensenellaceae may symbiotically play a role in PD pathology and progression
• [#Parkinson’s Disease] - Intestinal mucus layer is rich in protein mucin. Akkermansia utilises mucin as a nutritional source and degrades it into SCFA #Acetate, which acts as a substrate for other beneficial bacteria to produce butyrate, an energy source for the intestinal epithelial cells. - Akkermansia is a symbiont that degrades mucin and encourages cells to produce more mucin. - A compensatory effect of richness in Akkermansia is possibly due to depleting cellulose-degrading bacteria in the PD gut
• [1.11] 
  - Decreases in SCFA-producing bacteria, specifically belonging to Akkermansia and #Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical #Sleep Deprivation and 3-day continuous #Sleep Deprivation. - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption. - #Sleep Deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of #Lactobacillus plantarum.
• - patients with psoriasis report a relative reduction in intestinal abundance of Akkermansia, #Ruminococcus, or #Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
• [1.12] [#Inflamatory bowel disease] 
  - studies have demonstrated striking differences between luminal and mucosal samples within the colon itself, specifically regarding mucosa-associated bacteria such as #Bifidobacterium, #Lactobacillus, and Akkermansia. - the microbial community composition is different between ileal luminal samples from colonic and fecal samples, as well along the length of the colon itself.
• [1.13] [#Poly-unsaturated fatty acid] [#High satureted fat diet] 
  Presence of Akkermansia showed positive correlation with intake of saturated fats and negative correlation with respect to polyunsaturated fatty acids (PUFA) present in overall diet.
• [1.14] [#Multiple Sclerosis] [#Blautia wexlerae, #Erysipelotrichaceae CCMM] 
  - In both progressive MS and RRMS > increased #Clostridium bolteae, #Ruthenibacterium lactatiformans, and Akkermansia and decreased #Blautia wexlerae, #Dorea formicigenerans, and #Erysipelotrichaceae CCMM. - Unique to progressive MS, has elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased #Blautia and #Agathobaculum.
• [1.15] [#Cancer, #Neutropenia] 
  - Transferring gut microbiota from patients with neutropenic #Fever to irradiated mice promoted the development of subsequent #Fever. - An excess of mucin-degrading Akkermansia bacteria found in the transferred microbiomes of febrile patients, as well as in nontransplanted but irradiated or #Chemotherapy-treated mice that reduced their food intake, resulted in a compromised intestinal barrier in mice that could be circumvented by administration of propionate.
• [1.16] [#Parkinson’s Disease] 
  - PD > increased relative abundance of family Enterobacteriaceae, genera Akkermansia, #Lactobacillus, #Bifidobacterium. - PD > decreased relative abundance of family #Lachnospiraceae, #Faecalibacterium
• [1.17] [#Epigallocatechin gallate, #Short Chain Fatty Acid] 
  - ECGC contribute significantly also to increase the number of SCFAs-producing bacteria, especially Akkermansia, enhancing the colon barrier integrity and general anti-inflammatory effects.
• [1.18] 
  - #Breast cancer intramural Microbial biomarkers #Acinetobacter, #Citrobacter, #Enterobacter, #Staphylococcus, #Paracoccus and Akkermansia were differentially abundant in breast tumors from #Black women compared with those from white women.
• [1.19] [#Short Chain Fatty Acid] 
  - in #Centenarians, longevity is positively associated with an abundance of short-chain fatty acid (SCFA) producers, such as #Clostridium cluster XIVa, #Ruminococcaceae, Akkermansia, and #Christensenellaceae
• - good immunological and metabolic health-related bacteria, such as Akkermansia, #Christensenellaceae, and #Lactobacillus, were higher in #Centenarians than in other groups
• - #Coriobacteriaceae and Akkermansia correlated negatively with senescence-associated secretory phenotype (SASP).
• [#Clostridium clusters XIVa] - elevated levels of #Anaerotruncus spp., Clostridium XIVa, and #Lachnospiraceae in #Parkinson’s Disease patients were associated with dyskinesia symptoms in #Parkinson’s Disease patients, while elevations in Akkermansia were associated with non-motor impairments in #Parkinson’s Disease patients
• [1.21] [#Inflamatory bowel disease] [#Akkermansia muciniphila] [#Antibiotic Therapy] 
  - Conditions like inflammatory bowel disease (IBD), #Salmonella typhimurium infection or post-antibiotic reconstitution may not benefit from Akkermansia supplementation. - using Akkermansia in patients with endocrine and gynecological disorders—such as #Polycystic ovary syndrome (PCOS) or #Endometriosis—that have a higher risk of developing IBD, should be critically evaluated. - the gut microbiota of patients suffering from #Parkinson’s Disease or #Multiple Sclerosis exhibits a characteristic signature of Akkermansia municiphila abundance.
• [1.22] [#Whole grains] 
  - Several #Butyrate-producers (e.g., #Faecalibacterium, #Roseburia, Butyriciococcus) were inversely associated with colonic transit time and/or faecal pH, while the mucin-degraders Akkermansia and #Ruminococcaceae showed the opposite association.
• [1.23] [#Akkermansia muciniphila] 
  - greater increase in Akkermansia’s abundance in #Aspirin vs placebo > #Aspirin users, who do not have severe upper Gl complications, are likely to have increased mucin levels that contribute to host defense and potentially to a decrease in inflammation.
• - The abundance of Akkermansia increased more in the #Aspirin compared to the placebo group
• [1.24] [#Parkinson’s Disease] 
  - an increase of mucin-degrader (i.e., potential gut barrier disrupter) Akkermansia in RBD and early PD
• [#Parkinson’s Disease] - the genera Akkermansia and #Oscillospiraceae UCG-005, which have been identified as prodromal PD RBD-enriched - bacteria (e.g., #Collinsella and #Desulfovibrio) which were potentially related to PD pathogenesis were already increased in prodromal PD RBD patient
• [1.25] [#Systemic lupus erythematosus] 
  - SLE > The abundance of #Acholeplasma, #Capnocytophaga and #Leptotrichia were negatively correlated with SLEDAI score, and the abundance of #Bacteroides, #Ruminococcus and Akkermansia had an inverse correlation with the serum levels of complement C3
• [1.26] 
  - addition of #Tea #Polyphenols increased Akkermansia abundance in HF mice, which is consistent with previous research indicating that TP, #Cranberry, chlorogenic acid, and #Grape also increase the colonization of Akkermansia in the gut - increase in small intestinal goblet cells in TP-treated mice, which secrete mucins, a food source for Akkermansia development. - #Polyphenols increase intestinal mucus secretion which is the food source of Akkermansia.
• [1.27] [#Crohn’s disease] 
  - CD patients had higher abundances of a #Ruminococcus taxon and strongly depleted in a #Blautia ASV, and previous csDMARD therapy was associated with increased Akkermansia.
• [1.28] [#Parkinson’s Disease] [#Short Chain Fatty Acid] 
  - Decreases of short-chain fatty acid-producing genera, #Fusicatenibacter, #Faecalibacterium, and #Blautia, as well as an increase of mucin-degrading genus Akkermansia, predicted accelerated disease progression.
• [1.29] [#Oat] 
  - increase in #Bifidobacterium and Akkermansia, as well as a reduction in the #Sutterellaceae family when 80 g/d of oats were consumed as part of a normal diet for 45 days
• - The genetically predicted relative abundance of #Verrucomicrobiae, #Verrucomicrobiaceae, Akkermansia, #Verrucomicrobiales were positively associated with arthropathic #Psoriasis.
• - In patients with #Psoriatic Arthritis, there was a decrease in the abundance of certain bacteria such as Akkermansia, #Ruminococcus, #Pseudobotyrivibrio, #Paraacteroides, #Alistipes, and #Coprococcus
• [1.31] 
  - Akkermansia has demonstrated benefit in preventing #High Fat Diet-induced #Obesity as well as in alleviating #Obesity-related insulin resistance and inflammation. - Akkermansia has been associated with beneficial changes in gene expression related to adipocyte differentiation and inversely correlated to gene variants associated with body mass index
• [1.32] 
  - increase in the relative abundances of #Verrucomicrobiaceae and Akkermansia and a decrease in #Prevotellaceae and #Prevotella
• [#Alzheimer’s disease, #Parkinson’s Disease] - several studies have consistently reported a greater abundance of Akkermansia in the fecal samples of PD and AD patients than that in healthy controls
• [#Cancer, #Skin wound] - Akkermansia is associated with enhancement of wound healing, augmented antitumor responses, protection against #Obesity, and induced intestinal adaptive immune responses during homeostasis
• [#Parkinson’s Disease] - abundance of #Megasphaera and Akkermansia, and reduced #Roseburia in PD patients
• [1.33] [#Parkinson’s Disease] [#Fiber-free diet, #Low fibre Diet] 
  - The lack of dietary fiber makes specialized taxa, which are equipped with glycan-degrading enzymes, such as Akkermansia spp. or the Bacteriodetes genera #Alistipes spp. and #Bacteroides spp.,65 switch to host #Glycans as energy resource, promoting mucus erosion and pathogens susceptibility.
• [1.34] 
  - Only #Bifidobacterium and Akkermansia, have evolved the capacity to utilize mucin as a nutrient source
• [1.35] [#Non-Hodgkin lymphoma] [#CAR T-cell therapy] 
  - In Lymphoma > #Bacteroides, #Ruminococcus, #Eubacterium and Akkermansia were most important in determining CAR-T responsiveness, with Akkermansia also being associated with pre-infusion peripheral T cell levels in these patients.
• [1.36] [#Osteoporosis] 
  - treatment of gonadal-intact mice with pasteurized Akkermansia resulted to a reduction in trabecular and cortical bone mass
• [#Osteoporosis] - that greater abundances of the genera; Akkermansia and #DTU089, were associated with lower radius total vBMD, and tibia cortical vBMD respectively.
• [1.37] [#D-ribose] 
  - The increased Akkermansia might be the cause of intestinal barrier impairment in RIB-fed mice.
• [#Sugar] - feeding dietary simple sugars like #Glucose and #Fructose would enhance the abundance of Akkermansia.
• [#Depression] - Akkermansia was detected in much higher abundance in individuals with severe depressive symptoms. - Akkermansia might ameliorate chronic stress-induced depressive-like behaviors.
• [#Depression] [#Lachnospiraceae] [#D-ribose] - RIB-fed mice were characterized by 22 differential bacteria taxa on the Genera level, especially Akkermansia, #Turicibacter, and Lachnospiraceae_UCG-006
• [1.38] [#Short Chain Fatty Acid] 
  - #Electro-acupuncture treatment effectively ameliorated both pain and #Depression-like behaviors. - Electro-acupunctureprofoundly reshaped the gut microbiota composition, notably increasing the abundance of SCFAs-producing bacteria, particularly Akkermansia. - #Electro-acupuncture treatment > alterations of #BDNF, HDAC2, and AcH3
• [1.39] 
  - In chronic #Intermittent Hypoxia (CIH) mice, beneficial genera like #Clostridium, Akkermansia, and #Bacteroides reduced in presence while pathogenic genera like #Desulfovibrio increased.
• - Akkermansia, a mucin degrading bacterium in the #Verrucomicrobiaceae family, promotes mucus thickness and maintains gut barrier integrity.
• [#Immune checkpoint inhibitor] - an abundance of Akkermansia has been associated with a clinical benefit from immune checkpoint inhibitors in patients with non-small cell lung or renal #Cancer
• [#Colorectal cancer] - Akkermansia and #Bacteroides emerged as notable microbes enriched in yoCRC tumors as compared to Bacillus, #Staphylococcus, #Listeria, #Enterococcus, #Pseudomonas, #Fusobacterium, and #Escherichia/#Shigella which have consistently been implicated with higher relative abundance in aoCRC tumors
• - A lower abundance of Akkermansia has been linked with lifestyle diseases such as #Obesity, diabetes mellitus, #Hypertension, and liver steatosis.
• [1.41] 
  - in individuals diagnosed with Hashimoto’s thyroiditis > Akkermansia bacteria were more prevalent in both healthy individuals and those with Hashimoto’s thyroiditis with normal thyroid function, in contrast to the group of patients with Hashimoto’s with #Hypothyroidism
• [#Short Chain Fatty Acid] - SCFA-producing #Bacteria such as Akkermansia, #Butyrivibrio, #Holdemania, #Anaerostipes, and #Intestinimonas were identified in this study as part of the gut microbiota associated with #Hypothyroidism. - SCFAs play a crucial role in the regulation of sodium/#Iodine symporter (NIS) expression in thyroid cells.
• - Akkermansia, #Butyrivibrio, #Holdemania, and #Ruminococcaceae UCG-011 were identified as protective factors for #Hypothyroidism, whereas #Anaerostipes, #Intestinimonas, and Ruminiclostridium5 were found to have negative effects on the condition.
• [#Inflamatory bowel disease] - the abundance of Akkermansia is reduced in the intestinal mucosa of patients suffering from IBD
• [1.42] 
  colistin has an impact on the immune microenvironment of the testis and can downregulate serum testosterone levels in male mice through inhibition of Akkermansia, leading to destroyed #Inosine metabolism. Supplement with #Inosine can restore testosterone secretion probably by prompting the recovery of the intestinal mucus barrier and the serum lipopolysaccharides levels.
• [1.43] 
  - the predominant anti-inflammatory bacteria in the #Vitamin A Normal group are Akkermansia and #Verrucomicrobiales, while the anti-inflammatory bacterial communities in the VAS group belong to the genus #Desulfovibrio.
• [1.44] [#Depression] 
  - Species of #Coprococcus, Akkermansia, #Roseburia, and #Turicibacter were inversely associated with mood symptoms at age 5.
• [1.45] [#Schizophrenia] 
  - Megasphera, Akkermansia, #Fusobacterium and #Prevotella were significantly more abundant in SCZ patients, and #Citrobacter, #Blautia, #Coprococcus, #Lachnoclostridium were more abundant in HC controls.
• [1.46] [#Corticosteroid ] 
  - the steroid group had more #Megasphaera and Akkermansia.
• [1.47] 
  - depletion of the mucus layer by enriched Akkermansia sp. has been linked to higher susceptibility to a pathogen in an animal model.

References Notes