Neurotransmitters ⇒ GABA {60000051}
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Definition: | GABA |
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Initialisation date: | 2020-09-16 |
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Specification: | |
gamma-Aminobutyric acid, γ-aminobutyric acid | |
Source: | |
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Structural Type: | Amino acid |
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Functional Type: | Neurotransmitter |
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Notes:
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Shared Reference Notes
- [1.1]
- #Bifidobacterium can produce GABA - - #Lactobacillus can produce GABA
- [1.2]
- γ-aminobutyric acid (GABA) production by human-derived #Bacteroides is widespread, and there is a correlation between brain signatures of depression and fecal #Bacteroides levels in patients with #Major depressive disorder. - [1.3]
- #Bifidobacterium generate GABA. - [#Vaginally delivery] - Gamma aminobutyrate (GABA), a major CNS inhibitory neurotransmitter, is produced from #Lactobacillus and is the first bacterium that is colonized with most vaginally born infants.
- [1.4] [#Drug-resistant Epilepsy] [#Keto diet]
- ketogenic diet has been shown to increase the level of GABA in the cerebrospinal fluid of children with refractory epilepsy - - GABA producers > Bifidobacterium and Lactobacillus
- [#Irritable bowel syndrome] - In IBS patients, the GABAergic system is disrupted, and the levels of glutamate decarboxylase 2 (GAD2), GABA, and GABA receptors(including type B1 and B2) are decreased, while GABA transporter-2 (GAT-2) is increased in IBS-D patients
- - Fecal transplantation from #Schizophrenia patients to GF mice resulted in elevated levels of glutamine and GABA in the hippocampus, and led to #Schizophrenia-related behaviors
- [1.5]
- Elevated levels of #Glutamine and γ-aminobutyric acid (GABA) and reduced #Glutamate were observed in the hippocampus of germ-free mice that received fecal transplants from schizophrenic mice and showed #Schizophrenia-like behaviors. - [1.6] [#Parkinson’s Disease]
- In the PD metagenome, we noted a decrease in #Glutamate/glutamine synthesis gene-families and pathways, and a concomitant increase in both #Glutamate and GABA degradation. - [1.7]
- Low levels of GABA are linked to #Depression and mood disorders. - gut microbiota can alter GABA activity in the brain through the vagus nerve. - - #Eggerthella is involved in the synthesis of #Serotonin and gamma aminobutyric acid (GABA).
References Notes
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