Neurotransmitters ⇒ GABA {60000051}

Shared Reference Notes

• [1.1] 
  - #Bifidobacterium can produce GABA
• - #Lactobacillus can produce GABA
• [1.2] 
  - γ-aminobutyric acid (GABA) production by human-derived #Bacteroides is widespread, and there is a correlation between brain signatures of depression and fecal #Bacteroides levels in patients with #Major depressive disorder.
• [1.3] 
  - #Bifidobacterium generate GABA.
• [#Vaginally delivery] - Gamma aminobutyrate (GABA), a major CNS inhibitory neurotransmitter, is produced from #Lactobacillus and is the first bacterium that is colonized with most vaginally born infants.
• [1.4] [#Drug-resistant Epilepsy] [#Keto diet] 
  - ketogenic diet has been shown to increase the level of GABA in the cerebrospinal fluid of children with refractory epilepsy
• - GABA producers > Bifidobacterium and Lactobacillus
• [#Irritable bowel syndrome] - In IBS patients, the GABAergic system is disrupted, and the levels of glutamate decarboxylase 2 (GAD2), GABA, and GABA receptors(including type B1 and B2) are decreased, while GABA transporter-2 (GAT-2) is increased in IBS-D patients
• - Fecal transplantation from #Schizophrenia patients to GF mice resulted in elevated levels of glutamine and GABA in the hippocampus, and led to #Schizophrenia-related behaviors
• [1.5] 
  - Elevated levels of #Glutamine and γ-aminobutyric acid (GABA) and reduced #Glutamate were observed in the hippocampus of germ-free mice that received fecal transplants from schizophrenic mice and showed #Schizophrenia-like behaviors.
• [1.6] [#Parkinson’s Disease] 
  - In the PD metagenome, we noted a decrease in #Glutamate/glutamine synthesis gene-families and pathways, and a concomitant increase in both #Glutamate and GABA degradation.
• [1.7] 
  - Low levels of GABA are linked to #Depression and mood disorders. - gut microbiota can alter GABA activity in the brain through the vagus nerve.
• - #Eggerthella is involved in the synthesis of #Serotonin and gamma aminobutyric acid (GABA).

References Notes