Actinomycetaceae ⇒ Actinomyces {10000308} Record Keys Parent:Actinomycetaceae Definition:Actinomyces Details Initialisation date:2020-10-18 Meta Information Rank: Genus Domain: Bacteria Enzyme:[ ] Function:Nitrate-reducing Notes: [ ]Shared Reference Notes [1.1] [#Diabetes Type 1, #Diabetes Type 2] - Compared to the levels in non-diabetic individuals, diabetes patients exhibited a higher abundance of #Neisseria, TM7, #Gemella, #Eikenella, #Selenomonas, Actinomyces, #Capnocytophaga, #Fusobacterium, #Aggregatibacter, #Veillonella, and #Streptococcus genera and a lower abundance of Filifactor, Synergistetes, Tannerella, Eubacterium, Porphyromonas, and Treponema genera [1.2] [#Breast cancer] - Actinomyces and #Veillonella were more abundant in breast tumors of #White Women than in those of Black women. [1.3] [#Atherosclerosis, #Rheumatic Hearth Disease] [#Porphyromonas gingivalis] - Oral microbes, including P. gingivalis, Actinomyces, #Streptococcus, and #Treponema denticola, have been confirmed as sources of infected heart valves, atherosclerotic plaques, and rheumatic heart valves [#Primary sclerosing cholangitis] [#Roseomonas mucosa, #Streptococcus salivarius] - Even in the early stages, PSC patients’ stool and mucosa significantly enrich oral pathogenic bacteria such as #Streptococcus, #Veillonella, and Actinomyces (#Streptococcus salivarius is an independent predictor of liver-related three-year mortality) [1.4] [#Natural Small intestine Microbiome] [#Escherichia coli] - At the genus level, bacteria highly abundant in the SI include #Lactobacillus, #Veillonella, #Streptococcus, #Gemella, Actinomyces, and E. coli. [1.5] - Anaerobes such as Actinomyces, #Veillonella and #Fusobacterium are less prevalent in Oral mucos and mostly present at subgingival sites [1.6] [#Actinomyces odontolyticus] - In #Hepatobiliary cancers and metastatic #Melanoma, Actinomyces genus and members (e.g., Actinomyces odontolyticus) are consistently enriched in non-responders, whereas #Faecalibacterium prausnitzii is increased in responders. [1.7] [#Oral squamous cell carcinoma] - Oral cancer and epithelial precursor lesions are also linked with bacteria from genera #Fusobacterium, #Veillonella, Actinomyces, #Clostridium, #Haemophilus, and #Enterobacteriaceae [1.8] [#Alzheimer’s disease] [#Actinomyces meyeri] - #Actinomycetia, a class-level bacteria of A. meyeri, and Actinomyces, a genus-level bacteria of A. meyeri, have been found to be increased in the brain of AD patients [1.9] [#Biliary tract cancer, #Intrahepatic Cholangiocarcinoma, #Primary liver cancer] - enriched in ICC were Actinomyces, #Lactobacillus, #Peptostreptococcaceae, and #Alloscardovia. Furthermore, the #Glycoursodeoxycholic acid and #Tauroursodeoxycholic acid (TUDCA) plasma-stool ratios were significantly increased in ICC with the genera #Lactobacillus and #Alloscardovia exhibiting positive correlations with the TUDCA plasma-stool ratio. - These biomarkers could be used to differentiate ICC from hepatocellular carcinoma (HCC) [#Helicobacter pylori] - reduced levels of #Nesterenkonia but increased levels of #Methylophilaceae, #Fusobacterium, #Prevotella, Actinomyces, #Novosphingobium, and H. pylori in #Extrahepatic Cholangiocarcinoma cases. [#Multiple Sclerosis] - the abundance of Actinomyces genus, along with several #Actinomycetales compounds increased in the gut of MS patients. - there is a peptide from Actinomyces can mimic #Collagen type IV α3127–148 and become a source of autoimmunity, thus leading to anti-glomerular basement membrane disease in HLA DRB1*15:01 humanized miceReferences Notes (1) [1.77]
