Enterobacteriaceae ⇒ Proteus {10000604}

Shared Reference Notes

• [1.1] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] 
  The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) #Roseburia, #Eubacterium, #Subdoligranumum, #Ruminococcus - an increase in pro-inflammatory pathogens Proteus, #Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, #Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus.
• [1.2] [#Crohn’s disease] 
  - Escherichia/Shigella, #Enterococcus and Proteus were enriched in the advanced CD patients.
• [1.3] 
  - patients with PD exhibited a significantly high abundance of the intestinal conditional pathogens, such as #Enterococcus, #Escherichia-#Shigella, and Proteus. - The abundance of these pathogens was positively correlated with PD duration and unified #Parkinson’s Disease rating scale (UPDRS) score. - Bacillus and #Escherichia-#Shigella secrete #Amyloid protein and promote the occurrence of diseases. - #Amyloid proteins can induce oxidative stress, activate microglia, and release inflammatory factors such as TNF-α, IL-1 and IL-6 to increase to increase permeability of intestinal epithelial and BBB.
• [1.4] 
  - #Sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, #Desulfovibrio, #Escherichia coli, #Fusobacterium, #Klebsiella, #Lactobacillus, #Morganella, #Odoribacter, and Proteus.
• [1.5] [#Inflamatory bowel disease] [#Escherichia coli] 
  - #Colectomy > there was a significant increase in the expansion of E.coli in individuals who underwent surgery and, in particular, samples from IBD patients who underwent #Colectomy had the highest abundance of E.coli. - At 6 months, endoscopic recurrence was associated with elevated Proteus genera and at 18 months with reduced #Faecalibacterium, #Desulfovibrio and #Bilophila abundance. At 18 months severe endoscopic recurrence was associated with increase in #Proteobacteria.
• [1.6] 
  - #Lactobacillus, #Enterococcus, #Clostridium, and Proteus are gastrointestinal tract (GIT) bacteria that can use the #Triglyceride backbone as an electron sink, reducing glycerol to 1,3-propanediol
• [1.7] [#Colorectal cancer] 
  - #Methanethiol as a biomarker for non-invasive early #Cancer detection. - Commensal #Bacteria residing in the colonic lumen can convert dietary #Methionine to #Methanethiol through MGL-catalyzed α,γ-elimination and γ-replacement reactions. - #Fusobacterium nucleatum, #Citrobacter freundii, #Morganella morganii,and several Proteus species have been reported to contribute to intestinal #Methanethiol production

References Notes