Disease ⇒ Cancer ⇒ Cervical cancer {40000149} Record Keys Type:Disease Parent:Cancer Definition:Cervical cancer Details Initialisation date:2020-09-06 Other Terms:[ ] LinksWickipediaMerck Manual Meta Information MedDra ID:10062663 MedDra Level:llt ICD:[ ] Category:Urology, Oncology Zone:[ ] Mechanism:[ ] Notes: - Mycoplasmatales correlates directly with the severity of lesions and are more abundant in the presence of higher-grade lesions, and less abundant for lower-grade lesions. (1) - The bacteria could promote HPV infection directly or indirectly -- by causing chronic inflammation, which promotes HPV. (1)Shared Reference Notes [1.1] [#Lipopolysaccharide] - LPS > downregulate the expression of Fra-1 > reducing the inhibitory effect of Fra-1 on the proliferation of cervical cancer cells > development of cervical cancer. [1.2] - increased diversity of #Vaginal microbiota and reduced abundance of #Lactobacillus spp. contribute to #HPV acquisition, persistence, and development of cervical cancer. [1.3] [#Fusobacterium nucleatum] - F. nucleatum was suggested to be enriched in cervical cancer and #Esophageal cancer compared to adjacent healthy tissue. [#Reactive Oxygen Species] - #Chlamydia spp. have been described in cervical and #Ovarian cancer > decrease p53 signaling and DNA damage response, in facilitating the pathogen’s intracellular replication, induction of ROS production and DNA damage [1.4] - an obligate L-#Lactate-producing #Lactic acid bacterium found in tumors, #Lactobacillus iners, is associated with decreased survival in patients, induces chemotherapy and radiation resistance in cervical cancer cells, and leads to metabolic rewiring, or alterations in multiple metabolic pathways, in tumors. [1.5] [#Cervical intraepithelial neoplasia] - significantly lower abundance of #Lactobacillus mucosae in women with HR-#HPV infection compared to the control group. - changes in bacterial diversity were noted in Lactobacillus non-dominant (LND) samples compared to Lactobacillus-dominant (LD) in both HR-#HPV-infected and control groups. - LND samples in HR-#HPV-infected women exhibited a cervical dysbiotic state, characterized by Lactobacillus deficiency. - In turn, the LD HR-#HPV group showed an overrepresentation of #Lactobacillus helveticus.References Notes[ ]
