Corynebacteriaceae ⇒ Corynebacterium {10000263}

Shared Reference Notes

• [1.1] [#Cutibacterium acnes, #Staphylococcus epidermidis] 
  - #Acne > increased #Actinobacteria followed by #Firmicutes and #Proteobacteria, #Cutibacterium,#Staphylococcus and Corynebacterium. - C. acnes > major species in terms of mean abundance, followed by #Staphylococcus epidermidis (S. epidermidis) and #Staphylococcus hominis (S. hominis);
• [1.2] [#Atopic Dermatitis] [#Staphylococcus aureus, #Staphylococcus epidermidis] 
  - increased abundance of S. aureus with depletion of S. epidermidis and Corynebacterium spp. among AD patients. - S. epidermidis, a commensal present on non–inflamed skin, appears to be S. aureus best antagonist. - less severe flares of AD had higher counts of S. epidermidis whereas the more severe flares were associated with S. aureus
• [1.3] [#Covid-19] 
  - SARS-CoV-2-infected participants with Corynebacterium/#Dolosigranulum-dominant microbiome profiles were less likely to have respiratory symptoms than infected participants with other nasopharyngeal microbiome profiles
• [1.4] [#Parkinson’s Disease] 
  - Certain bacterial species of the genus Corynebacterium, #Porphyromonas, and #Prevotella have been noted to be significantly abundant in PD and associated with #SCNA genes. - An overabundance of the unusually low Corynebacterium and endotoxins of the #Porphyromonas and #Prevotella can trigger the PD pathology in the gut.
• [1.5] 
  - The most abundantly cultivated bacterial organisms in a normal healthy eye are coagulase-negative #Staphylococci, #Acinetobacter, #Methylobacterium, #Propionibacterium, #Pseudomonas, #Streptophyta, #Sphingomonas, and Corynebacterium species
• [1.6] 
  - babies who are delivered by #Cesarean section (C-section) are often colonized by bacteria that are more commonly found on the skin, including #Staphylococcus, #Propionibacterium or Corynebacterium
• [#Natural ear microbiota] - The microbiota of the ear canal is similar to that found on the skin. Therefore, Corynebacterium, #Staphylococcus, and #Propionibacterium genera are prevalent taxa. - middle ear is actually colonized by Proteobacteria, #Actinobacteria, and #Firmicutes
• [1.7] 
  -The antibacterial and antitumor defensin (HBD1) showed decreased levels in #Prostate cancer patients, while others (HBD2 and 3) were considerably increased. - Abundance of #Staphylococcus, Corynebacterium and #Oxyphotobacteria genera was significantly higher, the abundance of #Faecalibacterium and #Bacteroides genera were significantly lower in prostate tumor samples compared to non-tumor samples. - #Bacteroides, Parabacteroides and #Faecalibacterium abundance gradually decreased with the combined increase in HBD2 and HBD3. - Higher Corynebacterium and #Staphylococcus abundances were measured together with higher HBD2 and HBD3 urinary levels.
• [1.8] [#Natural Skin Microbiome] 
  - the moist sites of skin are primarily colonized by members of the genera #Staphylococcus and Corynebacterium.
• [1.9] 
  - #Kocuria and #Cutibacterium were enriched in healthy subjects, while #Staphylococcus was enriched in psoriatic disease. - The relative abundance of Corynebacterium was higher in NL #Psoriatic Arthritis (PsA). samples compared with NL #Psoriasis (PsO) samples.
• [#Ovarian cancer] - distinct OC microbiome with general enrichment of several microbial taxa, including #Dialister, Corynebacterium, Prevotella, and #Peptoniphilus in the OC cohort in all body sites excluding stool and omentum particularly in OC patients with adverse treatment outcomes compared to those without events.
• [1.11] 
  - in the patients with #Non-Atopic Dermatitis, an abundance of #Bacillus and #Brevibacillus was significantly increased while that of Corynebacterium was significantly decreased in affected vs. unaffected skin
• [1.12] [#Breast cancer] 
  - #Enterobacter, #Bacteroides, and #Bifidobacterium were more abundant in patients with BC. - #Pseudomonas, #Staphylococcus, #Acinetobacter, and Corynebacterium 1 were more abundant in healthy controls.
• - Corynebacterium 1 was increased after #Bellflower root intervention by 3.1-fold.
• [1.13] [#Natural Skin Microbiome] 
  - #Aging > significant increase in Corynebacterium on the cheeks and forehead and #Acinetobacter on the scalp in the older group.
• [#Natural Skin Microbiome] [#Aging] - At the genus level, old-aged skin exhibited an increase in Corynebacterium and a decrease in #Cutibacterium relative abundance
• [1.14] [#Cutibacterium acnes] 
  - #Cutibacterium acnes secretes a thiopeptide RiPP called #Cutimycin that inhibits members of #Staphylococcus but does not affect the members of the genera Corynebacterium and #Cutibacterium.
• -RiPPs from #Lactobacilli have shown to inhibit members of #Staphylococci, #Cutibacterium and Corynebacterium
• [1.15] 
  - The #Actinobacteria phylum includes pathogens (species of Corynebacterium, #Mycobacterium, #Nocardia, and #Propionibacterium), #Soil inhabitants (Micromonospora and #Streptomyces species), plant commensals (Frankia spp.), and GI commensals (#Bifidobacterium spp.)
• [1.16] [#Autoimmune disease] 
  - The genus Corynebacterium is a taxon of coryneform gram-positive bacilli or coccobacilli that colonize the mucous membranes and skin in humans. - Corynebacterium is usually regarded as a clinically non-significant contaminant in cultures28, but is sometimes reported in the context of autoimmune diseases.
• - Corynebacterium in the nasopharyngeal microbiome and peripheral blood leukocytes relates to #Kawasaki disease.
• - #Staphylococcus and #Streptococcus species, Corynebacterium species may serve as novel pathogenic candidate microbes for #Vasculitis.
• - Corynebacterium 1 in the gut was associated with disease duration, and serum IL-1β levels in patients with #Vitiligo
• [1.17] [#Skin aging] [#Corynebacterium kroppenstedtii] 
  - Cor. kroppenstedtii was likely responsible for the observed #Aging-related increase in Corynebacterium.
• [1.18] [#Natural Skin Microbiome] [#Actinobacteria] 
  - Belly button (BB) and between toes (BT) (moist microenvironment) were mainly comprised of Actinobacteriota and #Firmicutes; behind ears (BE) (oily microenvironment) was dominated by #Firmicutes; and calves (CA) and forearms (FA) (dry microenvironment) included a combination of those three phyla. - BB and BT (moist microenvironment) were dominated by #Staphylococcus and Corynebacterium, BE (oily microenvironment) by #Staphylococcus and #Anaerococcus, while CA and FA (dry microenvironment) showed a high proportion of #Staphylococcus and Corynebacterium, but also of #Streptococcus and #Escherichia-#Shigella. #Anaerococcus was also highly abundant in BB.
• [1.19] 
  - #Lactobacillus, #Bacillus, Corynebacterium, #Streptococcus, #Pseudomonas, #Staphylococcus, #Escherichia-#Shigella were observed to decrease in Viral #Keratitis microbiomes. And the abundance of some opportunistic pathogens such as #Rhodococcus were increased.
• - both #Staphylococcus and more recently Corynebacterium were implicated in pathogenesis of ANCA-associated #Vasculitis.
• [1.21] [#Atopic Dermatitis] 
  - AD #Infants skin microbiota composition in early life preceding AD onset was predominantly driven by the enrichment of #Pseudomonas stutzeri and reduction of #Staphylococcus and Corynebacterium species. - This bacterial signature was linked with lower natural moisturizing factors [NMF] (PCA, Urocanic acid-cis) and higher #Antimicrobial peptides [AMPs] (alpha and beta defensin) levels.
• [1.22] 
  - #Asthma exacerbations > higher abundance of #Staphylococcus and “oral” taxa, including #Neisseria, #Veillonella, and #Streptococcus spp. and a lower abundance of #Dolosigranulum pigrum, Corynebacterium, and #Moraxella spp.
• [1.23] [#Vulvar lichen sclerosus] 
  - Patients with VLS had a higher abundance of #Enterobacter cloacae, #Flavobacterium branchiophilum, #Mediterranea sp._An20, #Parabacteroides johnsoniiand #Streptococcus bovimastitidis on the vulvar skin, while Corynebacterium sp._zg-913 was less abundant compared to the control group.
• [1.24] [#Atopobium vaginae, #Gardnerella vaginalis, #Solobacterium moorei] [#Diet Inflammatory Index] 
  - Higher DII scores were associated with the enrichment of pro-inflammatory bacterial species, including S. moorei, a producer of pro-inflammatory #Sulfur compounds, and those associated with inflammatory perinatal conditions such as #Preterm birth and GDM, including G. vaginalis, A. vaginae and members of the Corynebacterium genera

References Notes