Disease ⇒ Systemic sclerosis {40000213} Record Keys Type:Disease Parent:[ ] Definition:Systemic sclerosis Details Initialisation date:[ ] Other Terms:SSc Meta Information MedDra ID:10042953 MedDra Level:llt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Atherosclerosis] - Trimethylamine (#TMA) is generated by the gut microbiome and in the host converted by flavin-containing monooxygenase (FMO3) into trimethylamine N-oxide (#TMAO), which has been implicated in chronic cardiovascular and metabolic diseases. - Using cell culture systems and patient biopsies > #TMAO reprograms skin fibroblasts, vascular endothelial cells, and adipocytic progenitor cells into myofibroblasts via the putative #TMAO receptor protein R-like endoplasmic reticulum kinase (PERK). - FMO3 was detected in skin fibroblasts and its expression stimulated by TGF-β1. - FMO3 was elevated in Systemic Sclerosis skin biopsies and in Systemic Sclerosis fibroblasts. [1.2] [#Diabetes Type 1] - #Covid-19 patients have a significantly higher risk to develop subsequent autoimmune diseases such as #Rheumatoid Arthritis, #Ankylosing spondylitis, systemic sclerosis, type I diabetes mellitus. [1.3] [#Diabetes Type 1, #Hashimoto’s thyroiditis, #Psoriasis, #Sjögren syndrome ] Patients with psoriatic disease had a significantly higher risk of #Crohn’s disease , #Ulcerative Colitis, #Systemic lupus erythematosus, #Rheumatoid Arthritis, #Ankylosing spondylitis , #Alopecia areata, and type 1 diabetes. - the risk of #Graves’ disease, Hashimoto’s disease, Sjögren’s syndrome, and systemic sclerosis was not significantly different between the groups.References Notes[ ]
