Microbiome & Chronic Diseases

Evidence Based Medicine

Wed 29 March 2023 Sign in

Disease ⇒ Systemic sclerosis {40000213}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Systemic sclerosis

Details
Initialisation date:	[ ]
Other Terms:	SSc

Meta Information
MedDra ID:	10042953
MedDra Level:	llt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

[ ]

Shared Reference Notes

[1.1] [#Atherosclerosis]
- Trimethylamine (#TMA) is generated by the gut microbiome and in the host converted by flavin-containing monooxygenase (FMO3) into trimethylamine N-oxide (#TMAO), which has been implicated in chronic cardiovascular and metabolic diseases. - Using cell culture systems and patient biopsies > #TMAO reprograms skin fibroblasts, vascular endothelial cells, and adipocytic progenitor cells into myofibroblasts via the putative #TMAO receptor protein R-like endoplasmic reticulum kinase (PERK). - FMO3 was detected in skin fibroblasts and its expression stimulated by TGF-β1. - FMO3 was elevated in Systemic Sclerosis skin biopsies and in Systemic Sclerosis fibroblasts.

References Notes

[ ]

↥ Microbiota

‐ Actinobacteria Cecum lavage sample Human [1.2]
‐ Bifidobacterium Cecum lavage sample Human [1.2]
‐ Bifidobacterium Sigmoid lavage sample Human [1.2]
‐ Burkholderia Tissue biopsie Human [1.3]
‐ Citrobacter Tissue biopsie Human [1.3]
‐ Erwinia Cecum lavage sample Human [1.2]
‐ Fusobacterium Cecum lavage sample Human [1.2]
‐ Fusobacterium Sigmoid lavage sample Human [1.2]
‐ Lactobacillus Cecum lavage sample Human [1.2]
‐ Lactobacillus Sigmoid lavage sample Human [1.2]
‐ Prevotella Cecum lavage sample Human [1.2]
‐ Prevotella Sigmoid lavage sample Human [1.2]
‐ Roseolovirus Tissue biopsie Human [1.3]
‐ Trabsulsiella Cecum lavage sample Human [1.2]
‐ Verrucomicrobium Cecum lavage sample Human [1.2]
‐ Vibrio Tissue biopsie Human [1.3]

↧ Microbiota

‐ Clostridium Cecum lavage sample Human [1.2]
‐ Faecalibacterium Cecum lavage sample Human [1.2]
‐ Faecalibacterium Sigmoid lavage sample Human [1.2]
‐ Malassezia Tissue biopsie Human [1.3]
‐ Propionibacterium Tissue biopsie Human [1.3]
‐ Rikenella Cecum lavage sample Human [1.2]
‐ Rikenella Sigmoid lavage sample Human [1.2]
‐ Staphylococcus Tissue biopsie Human [1.3]

Intervention by Microbiota

[ ]

↥ Metabolome

‐ TMAO Causal? Stool Human [1.1]

↧ Metabolome

[ ]

Intervention by Metabolome

[ ]

Related Factor

[ ]

Subclass

[ ]

References

[ ]

Author: MetaBiom
Identifier: 40000213
URL: https://www.metabiom.org/disease/113/systemic-sclerosis
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation [2022] [Study] [iScience] [Journal] [80002551]
[1.2] Association of systemic sclerosis with a unique colonic microbial consortium [2016] [Arthritis & Rheumatology] [Journal] [80000333]
[1.3] Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin [2019] [Arthritis Research & Therapy] [Journal] [80000940]