Eubacterium ⇒ Eubacterium rectale {10000528}

Shared Reference Notes

• [1.1] 
  - Two of the three E. rectale subspecies consistently harbored an accessory pro-inflammatory flagellum operon associated with lower gut microbiota community diversity, higher host BMI, and higher fasting blood insulin levels
• - Eubacterium rectale subspecies harboring flagellin-encoding genes were associated with a predominantly #Meat-based diet
• [1.2] 
  -The E. rectale bacteria ferment sulfoquinovose via a metabolic pathway that we have only recently deciphered, producing, among other things, a sulfur compound, dihydroxypropane sulfonate or DHPS for short, which in turn serves as an energy source for other intestinal bacteria such as Bilophila wadsworthia. Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,
• [1.3] 
  - Eubacterium rectale, one of the most prevalent human gut bacteria, can produce #Lauroyl tryptamine. - #Lauroyl tryptamine is able to bind a human receptor that plays a key role in regulating the immune system and controlling inflammation.
• [1.4] [#Behcet’s Disease] 
  - a similar effect was observed by the administration of Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of #Colchicine, which is used to treat BD patients.
• [1.5] [#Alzheimer’s disease] [#Bacteroides fragilis] [#Amyloid-beta] 
  - Presence of #Amyloid deposits was associated with greater abundance of proinflammatory taxa (#Escherichia/#Shigella), which were in turn correlated with proinflammatory cytokines, and with reduced abundance of Eubacterium rectale and B. fragilis, 2 taxa with anti-inflammatory activity
• [1.6] [#Covid-19] 
  -anti-inflammatory bacteria, including #Bifidobacteria species and Eubacterium rectale, with lower severity, and pro-inflammatory bacteria such as #Prevotella copri with higher severity.
• [1.7] [#Alzheimer’s disease] 
  - AD > A positive correlation between the pro-inflammatory cytokines and Escherichia/Shigella (pro-inflammatory taxon) and a negative correlation with Eubacterium rectale (anti-inflammatory taxon). - a decrease in #Firmicutes and #Bifidobacterium and increased levels of #Proteobacteria, #Actinobacteria - a disputed frequency of #Bacteroidetes in various studies..
• [1.8] [#Bacteroides massiliensis] 
  - #Prostate cancer > a higher relative abundance of Bacteriodes massiliensis as well as decreased relative abundances of #Faecalibacterium prausnitzii and Eubacterium rectale in the stool from men with PCa compared to the controls.
• [1.9] [#Chronic fatigue syndrome] 
  - #Faecalibacterium prausnitzii and Eubacterium rectale, which are both recognized as abundant, health-promoting #Butyrate producers in the human gut, were reduced in ME/CFS. - deficient microbial capacity for #Butyrate synthesis. - The abundance of #Faecalibacterium prausnitzii was inversely associated with fatigue severity.
• [#Actinomyces massiliensis] - #Athletes from 16 different sports > dominated by a single or a combination of five species, namely Eubacterium rectale, Polynucleobacter necessarius, #Faecalibacterium prausnitzii, #Bacteroides vulgatus, and #Gordonibacter massiliensis. - Species such as #Bifidobacterium animalis, #Lactobacillus acidophilus, #Prevotella intermedia, and F. prausnitzii were associated with #Athletes participating in high dynamic component sports.
• [1.11] [#Diabetes Type 1] 
  - Studies have reported an increased quantity of #Villanella, #Clostridium, and #Bacteroides and a decreased quantity of #Lactobacillus, Eubacterium rectale, #Blautia coccoides, and #Bifidobacterium in #Children with type 1 diabetes.
• [1.12] [#Resistant starch] 
  - RS could also be degraded by #Ruminococcus bromii, and #Bifidobacterium adolescentis, and also to a lesser extent by Eubacterium rectale and #Bacteroides thetaiotaomicron. - in the mixed bacterial and fecal incubations, RS degradation is impossible in the absence of R. bromii
• [1.13] [#Obesity] 
  - In obese people, high indigestible carbohydrate intake can significantly increase #Firmicutes bacteria such as Ruminococci, #Roseburia, and Eubacterium rectale, whereas a lack of dietary fermentable carbohydrate intake can significantly decrease #Butyric acid-producing bacteria and, consequently, fecal #Butyric acid content
• [1.14] [#Bacteroides uniformis, #Bacteroides vulgatus] 
  - #Bacteroidin-2 (produced by #Bacteroides cellulosilyticus) targeted several different classes including nearly all #Bacteroidia in our panel (except for B. uniformis and B. vulgatus), as well as #Akkermansia muciniphila, and Eubacterium rectale of the #Verrucomicrobiae and #Clostridia classes, respectively.
• - #Fusobacticin-2 (produced by #Fusobacterium nucleatum) from the oral microbiome has highly potent activity against the gut commensal Eubacterium rectale.
• [1.15] 
  - Eubacterium rectale and #Roseburia intestinalis, that were negatively correlated with SMR during the study period. - reduction of these species was associated with severer #Covid-19 manifestation.
• [1.16] [#Chronic fatigue syndrome] 
  - a significant decline in serum #Butyrate levels were found in ME/CFS patients. - decrease in #Butyrate-producing bacteria among ME/CFS patients involving genus/species like #Ruminococcus, #Faecalibacterium prausnitzii, and Eubacterium rectale. - the abundance of these species were negatively correlated with the severity of fatigue symptoms in ME/CFS patients.
• [1.17] [#Low fibre Diet] 
  - EEN feeding, mucus erosion still occurs but is offset by #Isobutyrate production. - #Isobutyrate production is both influenced by diet and contingent upon E. rectale.
• [1.18] [#Alzheimer’s disease] 
  - GPR183, an immunomodulatory EBI2 receptor, was recently reported to be antagonized by a gut metabolite #Lauroyl tryptamine derived from E. rectale.

References Notes