Fructooligosaccharides {90000467} Record Keys Parent:[ ] Definition:Fructooligosaccharides Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Fructooligosaccharides (FOS) modulated the gut microbiome profiles, such as an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level), and significantly increased the levels of Trp and 5-hydroxytryptamine (5-HT). [1.2] [#humanized Galactooligosaccharides, #Short Chain Fatty Acid] - prebiotics that promote SCFA production such as fructooligosaccharides (FOS), galactooligosaccharides (GOS) or #Inulin, have been shown to have multiple beneficial immune- and metabolic- effects that can ultimately improve cognition. [1.3] [#Bifidobacteria, #Bifidobacterium adolescentis, #Bifidobacterium pseudocatenulatum] [#Human milk oligosaccharides, #Inulin] - 2′FL/LNnT were bifidogenic for both age groups, 3′SL/6′SL and FOS/IN were exclusively bifidogenic for children and adults, respectively. - 3′SL/6′SL stimulated B. pseudocatenulatum (abundant in children), FOS/IN enhanced B. adolescentis (abundant in adults). - increased #Acetate, #Propionate and #Butyrate (only in adults) with product- and age-dependent differences. [1.4] [#humanized Galactooligosaccharides] - #Lactobacillus and #Bifidobacterium specialize in oligosaccharide fermentation, utilizing galactooligosaccharides (GOS), fructooligosaccharides (FOS), and #Polysaccharide #Inulin [1.5] [#humanized Galactooligosaccharides] - #Actinobacteria, #Bacteroidetes, and #Firmicutes, can ferment FOS, GOS, and xylooligosaccharides (XOS). - 15 g/day FOS for 3 weeks elevated #Bifidobacteria population in the feces and improved #Crohn’s disease - #Inulin (with DP of ≤60) can be fermented only by a few species, whereas a large number of microorganisms are able to degrade FOS [#Irritable bowel syndrome] [#humanized Galactooligosaccharides] - IBS symptoms improvement after consuming 5 g/day FOS for 6 weeks [101] or 3.5 g/day GOS for 12 weeks [1.6] [#Serotonin, #Tryptophan] - Fructooligosaccharides have been shown to modulate the gut microbial composition, by decreasing the abundance of #Akkermansiaceae (family level) and #Verrucomicrobia (phylum level) and increasing the abundance of #Ruminococcaceae (phylum level), and to increase the levels of Trp and 5-HT in mice models References Notes[ ]
