Disease ⇒ Spondyloarthritis {40000145} Record Keys Type:Disease Parent:[ ] Definition:Spondyloarthritis Details Initialisation date:2020-09-06 Other Terms:[ ] Meta Information MedDra ID:10071400 MedDra Level:pt ICD:[ ] Category:Musculoskeletal Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Ruminococcus gnavus was significantly higher in the gut microbiota of spondyloarthritis patients. [1.2] [#Calprotectin] - High cCLP serum levels are associated with worse structural outcomes in #Rheumatoid Arthritis and to a lesser extent, in spondyloarthritis. [1.3] - Patients with axial spondyloarthritis (SpA), #Acute anterior uveitis (AAU), and #Crohn’s disease > low abundances of #Lachnospiraceae taxa relative to controls, most notably #Fusicatenibacter, which was most abundant in controls receiving NSAID monotherapy and implied to partially mediate higher #Serum CRP. [#Ankylosing spondylitis] - Patients with SpA showed an enrichment of #Collinsella, and several Lachnospiraceae ASVs - HLA-B27+ individuals displayed enriched #Faecalibacterium. [1.4] - significant increases in the class #Bacilli, order #Lactobacillales, families #Lactobacillaceae and #Clostridiaceae, and genera #Lactobacillus and #Clostridium in non-colonized SpA patients. - SpA patients colonized by #Blastocystis showed significant increases in the phylum Pseudomonadota, class #Gammaproteobacteria, family #Succinivibrionaceae, and genus #Succinivibrio. - SpA patients > significant increase in the relative abundances of the family #Succinivibrionaceae and genus #Succinivibrio. [1.5] [#Collagen-induced arthritis , #Reactive arthritis] - IAA, #5-Hydroxytryptophan (5-HTP), and 5-HIAA ameliorate arthritis severity in proteoglycan-induced spondyloarthritis. CIA, and antigen-induced arthritis, respectively. [#Collagen-induced arthritis , #Rheumatoid Arthritis] [#Lachnospiraceae bacterium] - in CIA (such as Lachnospiraciae and Lactobacillaeae), RA (#Lachnospiraceae bacterium, #Lactobacillus spp., #Faecalibacterium), and SpA (#Ruminococcaceae, #Rikenellaceae, #Porphyromonadaceae, #Bacteroidaceae, #Lachnospiraceae) are either predicted or known to produce #Indole [1.6] [#Rheumatoid Arthritis, #Systemic lupus erythematosus] - #Ruminococcus gnavus was associated with lupus nephritis, RA and spondyloarthritis.References Notes[ ]
