Short Chain Fatty Acid ⇒ Propionic acid {60000095}

Shared Reference Notes

• [1.1] [#Parkinson’s Disease] 
  PD patient group, the abundance of proinflammatory microbes, such as #Clostridiales bacterium NK3B98 and #Ruminococcus sp AM07-15, significantly correlated with decreased fecal levels and increased plasma levels of SCFAs, especially propionic acid.
• [1.2] [#Multiple Sclerosis] 
  - Propionic acid, but not butyrate and acetate, was significantly reduced in blood and stool in MS patients with all disease subtypes, particular after relapse. - Supplementation of propionic acid promoted Treg cell function, and in long-term administration reduced relapse rate, disability and brain atrophy.
• [1.3] 
  - A higher relative abundance of #Alistipes species has been reported in children with #Autism, pervasive developmental disorder not otherwise specified (PDD-NOS) , and depression. - #Alistipes may disrupt the gut–brain axis by decreasing #Serotonin (indole-positive organism) and impair cognition by producing propionic acid in rats.
• [1.4] [#Gestational diabetes mellitus (GDM), #Pregnancy] [#Branched-chain amino acids, #Short Chain Fatty Acid] 
  In GDM: - Isobutyric, isovaleric, valeric, and hexanoic acids were significantly higher in the GDM. - #Isobutyric acid significantly correlated with urea and blood glucose at 1 and 2 hours after OGTT; fasting blood glucose, blood glucose at 2 hours after OGTT. - urea/creatinine ratio positively correlated with #Valeric acid. - blood glucose at 2 hours after OGTT positively correlated with #Caproic acid. - white blood cell count positively correlated with propionic acid. - Significantly elevated #Isobutyric acid and isovaleric acid in pregnant women with GDM may be associated with insulin resistance caused by BCFAs.
• [#Preeclamsia (PE), #Pregnancy] [#Short Chain Fatty Acid] in PE: - #Acetic acid, propionic acid, #Isobutyric acid, and valeric acids levels were significantly higher in the PE group. - the systolic blood pressure, diastolic blood pressure, urea/creatinine ratio, and total BA of pregnant women significantly positively correlated with #Acetic acid, propionic acid, #Isobutyric acid, and #Valeric acid. - urea positively correlated with #Acetic acid and #Isobutyric acid. - white blood cell count and gestational age negatively correlated with #Acetic acid, propionic acid, #Isobutyric acid, and #Valeric acid. - total cholesterol negatively correlated with propionic acid and #Isobutyric acid. - the percentage of neutrophils and fetal birth weight negatively correlated with #Isobutyric acid and #Valeric acid. - #Acetic acid and propionic acid have high diagnostic value for PE.
• [1.5] [#Propionibacterium acnes] 
• [1.6] [#Cutibacterium acnes] [#Ultraviolet Exposure] 

References Notes