Tryptophan ⇒ Norharman {90000569} Record Keys Parent:Tryptophan Definition:Norharman Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory, Anti-cancer, Antioxidant Notes: [ ]Shared Reference Notes [1.1] [#Acute Pancreatitis] - norharman could decrease the ratio of M1 macrophages in the pancreas and spleen to ameliorate tissue lesions of the pancreas and decrease the levels of serum enzymes and inflammatory factors (Tnf-α and Il-1β) in mice with AP. - enterobacterial metabolite norharman, which was partly exogenous and generated from #Tryptophan metabolism regulated by #Lactobacillus, showed the strongest inhibitory effect on M1 macrophage activation. - As a neuroactive β-carboline, norharman is a pyridoindole alkaloid that is naturally occurring, is plant-derived or in thermally processed foods, and is formed by the condensation of indoleamine (such as #Tryptamine) and formaldehyde, showing antioxidant, anti-inflammatory, and antitumor activities [#Raftlin] - norharman targets Rftn1 to restrain the M1 polarization of macrophages.References Notes[ ]
