Disease ⇒ Myasthenia gravis {40000371} Record Keys Type:Disease Parent:[ ] Definition:Myasthenia gravis Details Initialisation date:[ ] Other Terms:MG Meta Information MedDra ID:10028417 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Alternaria and Cladosporium species have been found to reveal acetylcholinesterase inhibitory activities. - acetylcholinesterase inhibitors are common therapeutics in MG, but further studies need to clarify potential benefits of these fungal genera in MG. [#Candida albicans] - in one MG patient, C. albicans was dominantly present. [1.2] - #Butyric acid-producing gut bacteria and serum #Butyric acid level are reduced in patients with AChR MG. - #Butyrate supplementation effectively enhanced Treg differentiation and their suppressive function of AChR MG. - #Butyrate activates autophagy of Treg cells by inhibiting the mammalian target of rapamycin. - Activation of autophagy increased oxidative phosphorylation and surface expression of cytotoxic T-lymphocyte-associated protein 4 on Treg cells, thereby promoting Treg differentiation and their suppressive function in AChR MG [1.3] [1.4] References Notes[ ]
