Disease ⇒ Osteoporosis ⇒ Postmenopausal osteoporosis {40000566} Record Keys Type:Disease Parent:Osteoporosis Definition:Postmenopausal osteoporosis Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Romboutsia, unclassified_Mollicutes, and Weissella spp. were enriched in the control group, whereas the abundances of Fusicatenibacter, Lachnoclostridium, and Megamonas spp. were higher in the osteoporosis group than in the other groups. Additionally, for VM, Lactobacillus was enriched in the control group, whereas the abundances of Peptoniphilus, Propionimicrobium, and Gallicola spp. were higher in the osteoporosis group than in the other groups. [1.2] - In PMO. Considering the positive association between #Devriesia and Bone Material Density, and the negative association between #Montagnulaceae and BMD, the two #Fungi species may play the beneficial and harmful roles during #Osteoporosis, respectively. - Lower gut microbiome diversity and a shift toward greater similarity to the male gut microbiome were confirmed in PMO patients - the enrichment #Lactobacillus sp. in non-PMO and the increased abundances of #Peptoniphilus sp., #Propionic acid bacteria, and members of the #Galicola genus in PMO - some novel metabolites, such as #Levulinic acid and #Pimelic acid, were significantly up-regulated in PMO population compared to non-PMO patients. [1.3] [#Lipopolysaccharide] - #Estrogen deficiency, the permeability of the gut increases leading to the translocation of harmful pathogens and the production of antigens (LPS) in the systemic circulation. [1.4] [#Osteoporosis] [#Bacteroides vulgatus] - several individual bacterial species (especially B. vulgatus) were significantly associated with bone mineral density (BMD) in ethnically distinct populations. - serum VA levels were positively associated with L1-L4 BMD; - B. vulgatus was negatively associated with serum VA levels and may causally suppress VA levels, presumably by inhibiting growth of VA-producing bacteria within the gut. - Serum #Valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. - Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. - NO effect of B. vulgatus on the sham-operated groups of mice, which indicates that the B. vulgatus may have distinct effects in eugonadic mice and estrogen deficient mice. References Notes[ ]
