Posibacteria ⇒ Lachnoclostridium {10000200}

Shared Reference Notes

• [1.1] [#Chronic kidney disease] 
  - #Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation. - After 6 months of #Curcumin supplementation > significantly lower #Escherichia-#Shigella and significantly higher Lachnoclostridium . - In the last 3 months of supplementation > significantly higher #Lactobacillaceae spp..
• [1.2] [#Diabetes Type 2] 
  - The genus #Blautia was one of the most represented genera in both groups enriched in group T2D. - Lachnoclostridium were more abundant in the microbiome profiles of diabetic patients. - There are anomalies in the genera #Bacteroides and #Prevotella, both of which are increased in the T2D, both genera are #Propionate producers.
• [1.3] [#Cancer] 
  - Lachnoclostridium depleted in other psychiatric disorders including #Schizophrenia and #Autism and in patients with gastrointestinal tract neoplasms.
• [#Depression] [#Christensenellaceae, #Coprococcus eutactus, #Lachnospiraceae] - RuminococcaceaeUCG005 as the most important genus in predicting depressive symptoms. - #Sellimonas, #Eggerthella, Lachnoclostridium and #Hungatella were more abundant in individuals with higher depressive symptoms. - 12 genera and 1 microbial family associated with depressive symptoms > genera #Sellimonas, #Eggerthella, #Ruminococcaceae (UCG002, UCG003, UCG005), Lachnoclostridium, #Hungatella, Coprococcus, LachnospiraceaeUCG001, Ruminococcusgauvreauiigroup, #Eubacterium ventriosum, #Subdoligranulum and family #Ruminococcaceae.
• [1.4] [#Alzheimer’s disease] 
  - Increased proportions of #Odoribacter and #Barnesiella and decreased proportions of #Eubacterium , #Roseburia , Lachnoclostridium and #Collinsella were seen in elders with other #Dementia types than AD.
• [#Alzheimer’s disease] - Increased proportions of #Bacteroides, #Alistipes, #Odoribacter, and #Barnesiella and decreased proportions of Lachnoclostridium were present in AD elders.
• [1.5] [#Diabetes Type 2, #Peripheral neuropathy] [#Sphingomyelin] [#High Fat Diet] 
  - #Lactobacillus, Lachnoclostridium, and #Anaerotruncus taxa variants positively correlated with several lipid species, particularly elevated plasma sphingomyelins and sciatic nerve triglycerides.
• [#Diabetes Type 2] - In type 2 diabetes patients, Lachnoclostridium correlated positively with total #Cholesterol and low-density lipoprotein #Cholesterol and a poorer metabolic profile
• [#Peripheral neuropathy] - #Lactobacillus, Lachnoclostridium, and #Anaerotruncus, correlated negatively with several free fatty acid and complex lipid species, including LysoPC 16:1, in both plasma and sciatic nerve.
• [1.6] [#Hepatocellular cancer] 
  - hepatocellular carcinoma > #Prevotella was enriched in patients with Progressive Disease. - hepatocellular carcinoma > Lachnoclostridium, #Lachnospiraceae, and #Veillonella were predominant in patients with objective responses.
• [#Hepatocellular cancer] - hepatocellular carcinoma > The coexistence of Lachnoclostridium enrichment and #Prevotella 9 depletion significantly predicted better overall survival (OS)
• [#Hepatocellular cancer] - hepatocellular carcinoma > #Ursodeoxycholic acid and #Ursocholic acid were significantly enriched in the feces of patients with objective responses and strongly correlated with the abundance of Lachnoclostridium.
• [1.7] [#Pulmonary tubercolosis, #Tuberculosis] 
  - The genera #Parabacteroides, #Bacteroides, Lachnoclostridium, and #Fusobacterium were markedly enhanced in the PTB group, while #Roseburia, #Blautia, unidentified #Ruminococcaceae, #Bifidobacterium, #Romboutsia, and #Fusicatenibacter were enhanced in the HC group.
• [1.8] 
  - #Kefir reduced triglycerides, #Uric acid, and affected the microbiome of animals increasing fecal #Butyrate-producing bacteria (#Lachnospiraceae and Lachnoclostridium).
• [1.9] [#Juvenile idiopathic arthritis] 
  - Lachnoclostridium was less abundant in ABISJIA, as in #Children with existing JIA.
• [#Fasting] - RIF was associated with significant drops in the levels of seven genera at the end of Ramadan: #Blautia, #Coprococcus, #Dorea, #Faecalicatena, #Fusicatenibacter, Lachnoclostridium, and #Mediterraneibacter.
• [#TMA] - Lachnoclostridium could affect cardiometabolic health by lowering #Acetate levels and producing harmful lipid compounds, including trimethylamine and CDP-diacylglycerol
• - Ramadan #Fasting > relative abundance values of Lachnoclostridium decreased.
• [#Obesity] - increased Lachnoclostridium is linked to visceral adipose tissue
• [1.11] [#Moyamoya disease] 
  - the relative abundance of the 2 genera, Lachnoclostridium and #Fusobacterium, increased in the MMD group, while the relative abundance of the 2 genera, #Bifidobacterium and #Enterobacter decreased in the MMD group.
• [1.12] [#Bacteroides dorei, #Clostridium symbiosum, #Lachnoclostridium clostridioforme] 
  - The absence of B. dorei impacted the abundance of the other 10 species negatively. - Lachnoclostridium symbiosum, a #Butyrate producer, appeared to be the most sensitive species to deletions, being stimulated by the presence of #Escherichia coli, #Bifidobacterium adolescentis, B. dorei, and #Lactobacillus plantarum.
• [1.13] [#Schizophrenia] 
  - Megasphera, #Akkermansia, #Fusobacterium and #Prevotella were significantly more abundant in SCZ patients, and #Citrobacter, #Blautia, #Coprococcus, Lachnoclostridium were more abundant in HC controls.
• [1.14] [#High temperature and humidity] 
  - HTH caused a distinct alteration of gut microbiota charactered as increased #Firmicutes/ #Bacteroidetes ratio, decreased #Prevotellaceae UCG-001 accompanied with increased Lachnoclostridium and #Candidatus saccharimonas at day 7. #Prevotellaceae UCG-001, involved in saccharolytic fermentation, probably contributed to the decreased plasma #Butyric acid level. - the decreased #Butyric acid recovered rapidly and could not explain the #GLP-1 suppression as butyrate supplement could not alleviate #GLP-1 decline
• [#High ambient temperature] - Lachnoclostridium is a genus of gram-positive, obligate anaerobic, spore-forming, motile bacteria. - Organisms in this genus can grow in moderate ‘mesophilic’ as well as in extremely high ‘thermophilic’ temperatures
• [#Lithocholic acid] - Lachnoclostridium is described with higher microbial capacity for bile acid conversion through a 7α-dehydratase process38, explained the robust increase in LCA abundance. - Lachnoclostridium produces trimethylamine (#TMA), which was turned into trimethylamine-N-oxide (#TMAO) in liver

References Notes