Disease
Microbiota ☳
Metabolome
Factor
Clostridiaceae ⇒ Clostridium {10000270}
Record Keys
Parent:
Definition: Clostridium
Details
Initialisation date: 2020-10-03
Meta Information
Rank:
Domain:
Zone: [ ]
Enzyme: [ ]
Function: Cholesterol-interacting
Notes:
[ ] Shared Reference Notes
[1.1 ] [#Polycystic ovary syndrome ] - #Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased #Lactobacillus and Clostridium species and decreased #Prevotella .
[1.2 ] - Clostridium spp. destroy tumors by secreting exotoxins that damage the membrane structures of #Cancer cells and enter cells to disrupt essential cellular functions.
- The introduction of Clostridium spp. recruits CD8+ T cells, granulocytes, and macrophages to the infection area and induces the release of TNF-related apoptosis-inducing ligand (TRAIL) from neutrophils.
[1.3 ] [#Crohn’s disease ] - Gut species found to be significantly depleted in CD compared to control include: #Faecalibacterium prausnitzii , #Roseburia inulinivorans and #Alistipes senegalensis .
- While Clostridium nexile and #Ruminococcus gnavus were found to be enriched.
[1.4 ] [#Bile Acids ] [#Western-style diet ] - WD consumption in conjunction with Clostridium spp. increased the secondary bile acid deoxycholic acid levels in the ileum, which in turn inhibited Paneth cell function.
[1.5 ] [#Diabetes Type 2 ] - Clostridium > negative correlation with with fasting glucose and HbA1c levels > decreased insulin resistance.
[1.6 ] [#Amyotrophic lateral sclerosis ] - ALS in mice> altered bacterial community related to autoimmunity (e.g., Clostridium sp. ASF502, #Lachnospiraceae bacterium A4), inflammation (e.g., #Enterohabdus Muris ,), and metabolism (e.g., #Desulfovibrio fairfieldensis ) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
[1.7 ] [#Alzheimer’s disease ] [#Bacillus firmus ] - B. firmus, Rikenella, Clostridium sp. Culture-27, and #Deoxyuridine , may play important roles in AD pathology.
[1.8 ] - the intestines and colon are enriched with anaerobes including the Clostridium and #Faecalibacterium genera.
[1.9 ] [#Lipopolysaccharide ] [#Antibiotic Therapy , #Condition of chronic stress ] - stressor exposed mice had significantly altered community structure of their gut microbiota, with decreased abundance of the genus #Bacteroides and increased abundance of the genus Clostridium . This was accompanied by increased circulating levels of IL-6 and monocyte chemoattractant protein 1 (MCP-1).
- In a follow-up experiment, animals were fed an antibiotic cocktail in the morning and evening by oral gavage, beginning three days before the stressor and continuing to the end of the experiment. Antibiotic treatment prevented the increases in IL-6 and MCP-1.
- mice receiving the stressor had elevated hepatic portal blood levels of LPS (from the gastrointestinal draining vein) and elevated mRNA expression of IL-1β, IL-6, and TNF in the hypothalamus, though no changes in circulating cytokines. Pretreatment with L. farciminis, antibiotics, and ML-7 all prevented these increases.
[#Culinary herbs and spices ] - six of seven aqueous culinary spice extracts of oregano, ginger, rosemary, cinnamon, black pepper and cayenne pepper were able to promote the growth of #Bifidobacterium spp. in vitro, whereas turmeric was not.
- stimulation of #Lactobacillus spp. and inhibition of certain Clostridium spp. by all seven spices.
- increase in most Clostridium spp. after turmeric and curcumin intervention in a human study.
[1.11 ] [#CVD ] [#Short Chain Fatty Acid ] [#Probiotic , #Probiotic (Bifidobacter and Lactobacilus) ] - Short-chain fatty acids and secondary #Bile Acids can decrease #Cholesterol levels by regulating #Cholesterol metabolism.
- Microbial #Bile Salt hydrolases can increase #Cholesterol disposal rates by accelerating its conversion to #Bile Acids .
- Probiotics from the genera Lactobacillus and Bifidobacterium are efficient reducers of #Cholesterol levels in clinical studies.
- Several candidate next-generation probiotics, including #Akkermansia muciniphila , #Bacteroides spp., Clostridium spp., #Christensenella minuta , Eubacterium spp., and #Faecalibacterium prausnitzii , have been shown to decrease #Cholesterol levels in human or animal studies.
[1.12 ] - levels of #Faecalibacterium prausnitzii , Bacteroides–Prevotella group, #Atopobium Cluster, #Enterobacter spp. and Clostridium Cluster IV were higher in BD patients than healthy subjects along with a reduced Bifidobacteria to Enterobacteriaceae ratio,
[1.13 ] - Butyrylated high-amylose maize resistant starch decreased red meat-derived pro-mutagenic adduct O6-methyl-2-deoxyguanosine and related CRC risk.
- Certain #Butyrate -producing bacteria such as Clostridium , #Ruminococcus , #Faecalibacterium spp., #Eubacterium spp., and #Roseburia , were found to decrease in relative frequency in CRC patients.
- #Butyrate inhibited the growth of CRC cells and induced their apoptosis in vitro at pharmacologically high concentrations.
[1.14 ] [#Plastics ] - #Muribaculaceae decreased and Clostridium increased in disposable paper cups group.
[1.15 ] - Five bacterial phyla including #Firmicutes , #Bacteroidetes , #Actinobacteria , #Proteobacteria , and #Fusobacteria can participate in #Tryptophan metabolism, being those belonging to the Clostridium , #Burkholderia , #Streptomyces , #Pseudomonas or #Bacillus genera the most important modulators
[1.16 ] [#High-protein diet ] - Excessive protein intake > causing the growth of protein fermenting bacteria as Clostridium , #Desulfovibrio , #Peptostreptococcus , #Acidaminococcus , #Veillonella , #Propionibacterium , Bacillus, #Bacteroides , #Staphylococcus , and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides , #Lactobacillus , #Bifidobacterium , #Prevotella , #Ruminococcus , #Roseburia , and #Faecalibacterium .
[1.17 ] [#Infants ] - Bacterial genera commonly found in the infant small intestine include #Lactobacillus , Clostridium , #Staphylococcus , #Streptococcus , #Bacteroides , and #Bifidobacterium
[#Human breast milk ] - Phosphatidylethanolamines (PEs) are integral to the outer Milk fat globules bilayer membrane, and while they are important for human cell proliferation during early life, some bacteria of the Clostridium and #Enterococcus genera use ethanolamine as a source of carbon and nitrogen.
[1.18 ] - Clostridium ssp. are required for the biotransformation of catecholamines into their bioactive form owing to their β-glucuronidase enzymes.
[1.19 ] [#Anorexia nervosa ] [#Clostridium bolteae , #Clostridium innocuum ] - In AN : #Erysipelatoclostridium ramosum , #Blautia species CAG, and Enterocloster bolteae innocuum (Clostridium ) were increased.
[#Anorexia nervosa ] - IN AN > Clostridium counts correlated positively with eating disorder scores.
[#Inflamatory bowel disease ] [#Clostridioides difficile , #Fusobacterium nucleatum ] - F. nucleatum coexists with Clostridium through adhesin RadD, encouraging the intestinal mucus layer’s bacterial biofilm formation in IBD patients. This symbiotic relationship accelerates the extracellular polysaccharides-producing process and chemotaxis level of C. difficile
[1.21 ] [#Natural Small intestine Microbiome ] - Only select bacteria, including Clostridium , #Lactobacillus , and #Enterococcus species, are able to penetrate, or attach to, the mucus layer at the epithelium and use the mucus as an energy source
[1.22 ] - Extra-virgin #Olive oil ingestion in rodents also can promote the growth of certain types of beneficial #Bacteria including species of #Lactobacillus , #Bifidobacterium , #Bacteroides , and Clostridium , and members of the Erysipelotrichaeae.
Impact in Disease
‐ Anorexia nervosa Deteriorative Observational ↥ Live Native Gut Human [1.19 ]
Author: MetaBiom
Identifier: 10000270
URL: https://www.metabiom.org/microbiota/165/clostridium
Keywords: Microbiome, Dysbiosis, Microbiota, Organism, Bacteria
Common References
[1.1 ] Polycystic Ovary Syndrome and the Gut Microbiome [2021] [Report] [WholeFoods MAGAZIN] [Blog] [80001774 ]
[1.2 ] Tweak to Treat: Reprograming Bacteria for Cancer Treatment [2021] [Review] [Trends in Cancer] [Journal] [80001782 ]
[1.3 ] Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease [2021] [Research] [Gut Pathogens] [Journal] [80001846 ]
[1.4 ] Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation [2021] [Research] [Cell Host & Microbe] [Journal] [80001850 ]
[1.5 ] Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives [2018] [Review] [Protein & Cell] [Journal] [80002107 ]
[1.6 ] Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis [2021] [Study] [Gut microbes] [Journal] [80002373 ]
[1.7 ] Gut microbiota may be involved in Alzheimer’s disease pathology by dysregulating pyrimidine metabolism in APP/PS1 mice [2022] [Study] [Frontiers in Aging Neuroscience] [Journal] [80002507 ]
[1.8 ] The double-edged sword of probiotic supplementation on gut microbiota structure in <i>Helicobacter pylori</i> management [2022] [Gut microbes] [Journal] [80002569 ]
[1.9 ] Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience [2020] [Review] [Neurobiology of Disease] [Journal] [80002658 ]
[1.10 ] Gut microbial modulation by culinary herbs and spices [2023] [Review] [Food Chemistry] [Journal] [80002681 ]
[1.11 ] Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease [2023] [Research] [Trends in Microbiology] [Journal] [80002694 ]
[1.12 ]  [2023] [Review] [Molecular Psychiatry] [Journal] [80002728 ]
[1.13 ] Microbial Metabolite Dysbiosis and Colorectal Cancer [2023] [Review] [Gut and Liver] [Journal] [80002741 ]
[1.14 ] Effects of common plastic products heat exposure on cognition: Mediated by gut microbiota [2023] [Study] [Ecotoxicology and Environmental Safety] [Journal] [80002824 ]
[1.15 ] Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities [2023] [Review] [Molecular Psychiatry] [Journal] [80002837 ]
[1.16 ] Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training [2020] [Review] [Nutrients] [Journal] [80002842 ]
[1.17 ] The role of human milk fats in shaping neonatal development and the early life gut microbiota [2023] [Review] [Microbiome Research Reports] [Journal] [80002843 ]
[1.18 ] The Gut Microbiota Links Dietary Polyphenols With Management of Psychiatric Mood Disorders [2019] [Review] [Frontiers in Neuroscience] [Journal] [80002856 ]
[1.19 ] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice [2023] [Study] [Nature Microbiology] [Journal] [80002863 ]
[1.20 ] Regulatory effects of oral microbe on intestinal microbiota and the illness [2023] [Review] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002875 ]
[1.21 ] The emerging role of the small intestinal microbiota in human health and disease [2023] [Review] [Gut microbes] [Journal] [80002887 ]
[1.22 ] Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health [2021] [Study] [Nutrition Reviews] [Journal] [80002976 ]
[1.23 ] Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption [2019] [Gut microbes] [Journal] [80001029 ]
[1.24 ] Temporal and long-term gut microbiota variation in allergic disease: a prospective study from infancy to school age [2019] [Allergy] [Journal] [80001034 ]
[1.25 ] Gut microbiota dysbiosis is associated with altered bile acid metabolism in infantile cholestasis [2019] [mSystems] [Journal] [80001288 ]
[1.26 ] Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis [2018] [Scientific Reports] [Journal] [80000689 ]
[1.27 ] Microbiome in Chronic Kidney Disease (CKD): An Omics Perspective [2022] [Review] [Toxins] [Journal] [80002388 ]
[1.28 ] Intestinal microflora in patients with liver cirrhosis [2004] [Chines Journal of Digestive Diseases] [Journal] [80000238 ]
[1.29 ] Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation [2012] [American Journal of Physiology-Gastrointestinal and Liver Physiology] [Journal] [80000587 ]
[1.30 ] Decreased fecal bacterial diversity and altered microbiome in children colonized with Clostridium difficile [2019] [Journal of Pediatric Gastroenterology and Nutrition] [Journal] [80000958 ]
[1.31 ] Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease [2018] [Journal of Gastroenterology] [Journal] [80000679 ]
[1.32 ] Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment [2012] [Genome Biology] [Journal] [80000991 ]
[1.33 ] Molecular-phylogenetic characterization of the microbiota in ulcerated and non-ulcerated regions in the patients with Crohn’s Disease [2012] [PLOS ONE] [Journal] [80000576 ]
[1.34 ] Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study [2013] [BMC Medicine] [Journal] [80000311 ]
[1.35 ] Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota [2018] [Gut] [Journal] [80000711 ]
[1.36 ] Featured gut microbiomes associated with the progression of chronic hepatitis B disease [2020] [Frontiers in Microbiology] [Journal] [80001369 ]
[1.37 ] Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma [2018] [Gut] [Journal] [80000859 ]
[1.38 ] Alterations of the gut microbiome in hypertension [2017] [Frontiers in Cellular and Infection Microbiology] [Journal] [80000630 ]
[1.39 ] Characterization of the gut microbiota of Kawasaki disease patients by metagenomic analysis [2015] [Frontiers in Microbiology] [Journal] [80000556 ]
[1.40 ] Conjuctival dysbiosis in mucosa-associated lyphoid tissue lymphoma [2019] [Scientific Reports] [Journal] [80001109 ]
[1.41 ] Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course [2019] [Scientific Reports] [Journal] [80001262 ]
[1.42 ] Correlation between body mass index and faecal microbiota from children. [2016] [Clinical Microbiology and Infection] [Journal] [80000316 ]
[1.43 ] The microflora associated with human oral carcinomas [1998] [Oral Oncology] [Journal] [80000771 ]
[1.44 ] Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis. [2011] [Inflammatory Bowel Diseases] [Journal] [80000242 ]
[1.45 ] Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation [2020] [Gut] [Journal] [80001256 ]
[1.46 ] Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy [2017] [Gut] [Journal] [80000594 ]
[1.47 ] Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [2017] [World journal of gastroenterology] [Journal] [80000752 ]
[1.48 ] An increased abundance of clostridiaceae characterizes arthritis in inflammatory bowel disease and rheumatoid arthritis: a cross-sectional study [2018] [Inflammatory Bowel Diseases] [Journal] [80000856 ]
[1.49 ] Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study [2018] [Schizophrenia Research] [Journal] [80000800 ]
[1.50 ] Connection between the Gut Microbiome, Systemic Inflammation, Gut Permeability and FOXP3 Expression in Patients with Primary Sjögren’s Syndrome [2020] [Research] [International journal of molecular sciences] [Journal] [80001479 ]
[1.51 ] Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency [2019] [The Journal of Allergy and Clinical Immunology] [Journal] [80000914 ]
[1.52 ] Gut microbiota alterations in Alzheimer’s Disease [2017] [Scientific Reports] [Journal] [80000621 ]
[1.53 ] Potential role of gut microbiota in ALS pathogenesis and possible novel therapeutic strategies [2018] [Journal of Clinical Gastroenterology] [Journal] [80000818 ]
[1.54 ] Role of the gut microbiota in the development of various neurological diseases [2022] [Review] [NeurologĂa (English Edition)] [Journal] [80002479 ]
[1.55 ] Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. [2017] [Genome Biology] [Journal] [80000612 ]
[1.56 ] Microbiota in anorexia nervosa: the triangle between bacterial species, metabolites and psychological tests [2017] [PLOS ONE] [Journal] [80000755 ]
[1.57 ] Mucosal Microbiome in Patients with Recurrent Aphthous Stomatitis [2014] [Study] [Journal of Dental Research] [Journal] [80000521 ]
[1.58 ] Distinct pattern of commensal gut microbiota in toddlers with eczema [2006] [International Archives of Allergy Immunology] [Journal] [80000546 ]
[1.59 ] A metagenomic study of the gut microbiome in Behcet’s disease [2018] [Microbiome] [Journal] [80000793 ]
[1.60 ] Alteration of the gut microbiota in Chinese population with chronic kidney disease [2017] [Scientific Reports] [Journal] [80000616 ]
[1.61 ] The lung microbiome in moderate and severe chronic obstructive pulmonary disease. [2012] [PLOS ONE] [Journal] [80000385 ]
[1.62 ] Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome [2022] [Cohort study] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002311 ]
[1.63 ] Metagenomic analysis of crohn’s disease patients identifies changes in the virome and microbiome related to disease status and therapy, and detects potential interactions and biomarkers [2015] [Inflammatory Bowel Diseases] [Journal] [80000446 ]
[1.64 ] Colinic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype [2011] [PNAS] [Journal] [80001200 ]
[1.65 ] Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia [2019] [EBioMedicine] [Journal] [80001184 ]
[1.66 ] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. [2017] [PLOS ONE] [Journal] [80000396 ]
[1.67 ] Evolution of the gut microbiome following acute HIV-1 infection [2019] [Microbiome] [Journal] [80001103 ]
[1.68 ] Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents [2020] [Gut] [Journal] [80001376 ]
[1.69 ] Gut microbiota dysbiosis contributes to the development of hypertension [2017] [Review] [Microbiome] [Journal] [80000033 ]
[1.70 ] Alterations in the gut bacterial microbiome in fungal keratitis patients [2018] [PLOS ONE] [Journal] [80000884 ]
[1.71 ] Specific gut microbiome signature predicts the early-stage lung cancer [2020] [Gut microbes] [Journal] [80001413 ]
[1.72 ] Reduced anti-inflammatory gut microbiota are associated with depression and anhedonia [2020] [Journal of Affective Disorders] [Journal] [80001308 ]
[1.73 ] An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide [2019] [Scandinavian Journal of Gastroenterology] [Journal] [80001213 ]
[1.74 ] Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters. [2015] [PLOS ONE] [Journal] [80000233 ]
[1.75 ] Altered gut microbiota in myasthenia gravis [2018] [Frontiers in Microbiology] [Journal] [80000850 ]
[1.76 ] Fecal and blood microbiota profiles and presences of nonalcoholic fatty liver disease in obese versus lean subjects [2019] [PLOS ONE] [Journal] [80001021 ]
[1.77 ] Alteration of the fecal microbiota in North-Eastern Han Chinese population with sporadic Parkinson’s disease [2019] [Neuroscience Letters] [Journal] [80001306 ]
[1.78 ] Aberrant intestinal microbiota in individuals with prediabetes [2018] [Diabetologia] [Journal] [80000677 ]
[1.79 ] Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects [2018] [Schizophrenia Research] [Journal] [80000808 ]
[1.80 ] Shared gut, but distinct oral microbiota composition in primary Sjögren’s syndrome and systemic lupus erythematosus_DUBLICATE [2019] [Journal of Autoimmunity] [Journal] [80000923 ]
[1.81 ] Comparison of the ocular microbiome between chronic Stevens-Johnson syndrome patients and healthy subjects [2020] [Scientific Reports] [Journal] [80001339 ]
[1.82 ] Association of systemic sclerosis with a unique colonic microbial consortium [2016] [Arthritis & Rheumatology] [Journal] [80000333 ]
[1.83 ] Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease [2020] [Gut microbes] [Journal] [80001255 ]
[1.84 ] Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of age [2022] [Cohort study] [Gut microbes] [Journal] [80002582 ]
[1.85 ] Rethinking healthy eating in light of the gut microbiome [2022] [Review] [Cell Host & Microbe] [Journal] [80002441 ]
[1.86 ] Human milk nutrient fortifiers alter the developing gastrointestinal microbiota of very-low-birth-weight infants [2022] [Study] [Cell Host & Microbe] [Journal] [80002552 ]
[1.87 ] Effects of Heat Stress on Gut Microbiome in Rats [2021] [Research] [Indian Journal of Microbiology] [Journal] [80002087 ]
[1.88 ] A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration [2022] [Review] [Frontiers in Systems Biology] [Journal] [80002487 ]
[1.89 ] Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies [2018] [Research] [Microbiome] [Journal] [80000217 ]
[1.90 ] Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis [2022] [Research] [Cells] [Journal] [80002575 ]