Tauroursodeoxycholic acid {90000504} Record Keys Parent:[ ] Definition:Tauroursodeoxycholic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Indole-3-propionic acid, #Short Chain Fatty Acid] - #Fasting considerably increased plasma levels of indolepropionic acid and tauroursodeoxycholic acid and fecal levels of SCFAs. [1.2] [#Polycystic ovary syndrome] - PCOS > reduction of bile acid (#Glycodeoxycholic acid and tauroursodeoxycholic acid) and #IL-22 secretion - administration of #Chenodeoxycholic acid could improve PCOS phenotypes in mice experiments. [1.3] [#Parkinson’s Disease] - tauroursodeoxycholic acid can rescue mitochondrial function and prevent 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced dopaminergic cell death in different animal models of PD [1.4] [#Biliary tract cancer, #Intrahepatic Cholangiocarcinoma, #Primary liver cancer] - enriched in ICC were #Actinomyces, #Lactobacillus, #Peptostreptococcaceae, and #Alloscardovia. Furthermore, the #Glycoursodeoxycholic acid and tauroursodeoxycholic acid (TUDCA) plasma-stool ratios were significantly increased in ICC with the genera #Lactobacillus and #Alloscardovia exhibiting positive correlations with the TUDCA plasma-stool ratio. - These biomarkers could be used to differentiate ICC from hepatocellular carcinoma (HCC) [1.5] [#Diabetes Type 1] [#Bile Acids] - TUDCA, a conjugated secondary BA, was observed to reduce the incidence of diabetes development by improving the #Glucose utilization and metabolism in streptozotocin-treated C57BL/6 mice [1.6] [#Amyloid-beta] - tauroursodeoxycholic acid (TUDCA) reduces Aβ deposition, inhibits the progression of amyloid pathology and suppresses GSK3β activity, thereby reducing #Tau hyperphosphorylation and microglial cell activation. - TUDCA can bind to the G protein-coupled bile acid receptor 1/Takeda G protein-coupled receptor 5 (GPBAR1/TGR5) in microglial cells, increasing cAMP levels, inducing an anti-inflammatory phenotype of microglial cells, and attenuating inflammatory response References Notes[ ]
