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Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Celiac Disease {40000207}

Record Keys


Type:
Disease
Definition:
Celiac Disease
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
CD, Coaliac disease

Links


Meta Information


MedDra ID:
10009839
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Immunology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

Shared Notes


  • [1.19
    - H. pylori has a mild protective role against celiac disease. Although this negative association is not strong.
  • [1.14
    - increase in Actinobacteria species in the upper tract (pharynx and duodenum), and an increase in Proteobacteria in the lower tract (duodenum and stool).
    - The effect of adherence to a gluten-free diet (GFD) evidenced by an increase in beneficial bacteria and a decrease in some Betaproteobacteriales but not fully restoring CeD-related dysbiosis.
    - gut microbiota acts as an enhancer of immune response in CeD through the production of lipopolysaccharides and other bacterial components that activate the immune response and by decrease SCFA producers bacteria.
  • [1.22
    - Pre-existing fecal microbiome diversity was unaffected by gluten challenge in adult subjects with CD and NCGS. These findings suggest that current microbiome status is unrelated to current disease activity and disease severity.
  • [1.18
    - Bacteroides vulgatus is increased in Infants with the genotype of high risk of celiac disease development.
    - Increased Bacteroides fragilis increase the risk for celiac disease development in genetically predisposed infants who were formula-fed.
    - Polysaccharide A produced by Bacteroides fragilis direct the immune system via its ability to direct the development of CD4+ T cells, thus inducing the differentiation of Th1-lineage.
    - Increased abundance of Bacteroides may contribute to the Th1 response found in the small intestinal mucosa of celiac disease patients.

Common References