Disease ⇒ Coronary artery disease {40000234} Record Keys Type:Disease Parent:[ ] Definition:Coronary artery disease Details Initialisation date:[ ] Other Terms:CAD Meta Information MedDra ID:10011078 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Long-term increases in TMAO were associated with higher CHD risk, and repeated assessment of TMAO over 10 years improved the identification of people with a higher risk of CHD. - Diet may modify the associations of ΔTMAO with CHD risk [1.2] [#Atherosclerosis] - #Bilophila, a genus of gut microbes, can metabolize #TMA, resulting in lower #TMAO, suggesting that differences in #TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from #TMAO. - #TMAO levels are also associated with #Heart failure and coronary artery disease. - #TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease. [1.3] - a precursor to #TMAO, #trimethyllysine (TML), alone and combined with TAMO, is involved in cardiovascular events for patients with the acute coronary syndrome. [1.4] - genus #Oxalobacter was positively associated with the risk of CAD. [1.5] [#Atrial fibrillation] - #Eisenbergiella borderline differentially abundant in incident AF and significantly related to prevalent AF. - #Eisenbergiella is more abundant in normotensive persons. - the abundance of this genus is different in coronary artery disease patients. Which is a strong predictor and established risk factor of AF. [1.6] [#CVD] [#Phenylacetylglutamine] - the association between PAG and incident CAD is independent of inflammation, as the association remained significant after adjustment for CRP in MDC-CC. - #Glutamate was strongly positively correlated and beta-carotene inversely correlated with cardiovascular risk factors. [#Phenylacetylglutamine] - three genera in the #Lachnospiraceae family that were inversely correlated with PAG, were themselves positively correlated with the FRS. - association between PAG and incident CAD is significant in both individuals with high and with low of FRS.References Notes[ ]
