Disease ⇒ Coronary artery disease {40000234}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Coronary artery disease

Details
Initialisation date:	[ ]
Other Terms:	CAD

Meta Information
MedDra ID:	10011078
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

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Shared Reference Notes

[1.1]
- Long-term increases in TMAO were associated with higher CHD risk, and repeated assessment of TMAO over 10 years improved the identification of people with a higher risk of CHD. - Diet may modify the associations of ΔTMAO with CHD risk
[1.2] [#Atherosclerosis]
- #Bilophila, a genus of gut microbes, can metabolize #TMA, resulting in lower #TMAO, suggesting that differences in #TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from #TMAO.
- #TMAO levels are also associated with #Heart failure and coronary artery disease. - #TMAO enhances the responsiveness of platelets to multiple agonists, promoting platelet hyperactivity and thus thrombosis and subsequent cardiovascular disease.
[1.3]
- a precursor to #TMAO, #trimethyllysine (TML), alone and combined with TAMO, is involved in cardiovascular events for patients with the acute coronary syndrome.
[1.4]
- genus #Oxalobacter was positively associated with the risk of CAD.
[1.5] [#Atrial fibrillation]
- #Eisenbergiella borderline differentially abundant in incident AF and significantly related to prevalent AF. - #Eisenbergiella is more abundant in normotensive persons. - the abundance of this genus is different in coronary artery disease patients. Which is a strong predictor and established risk factor of AF.
[1.6] [#CVD] [#Phenylacetylglutamine]
- the association between PAG and incident CAD is independent of inflammation, as the association remained significant after adjustment for CRP in MDC-CC.
- #Glutamate was strongly positively correlated and beta-carotene inversely correlated with cardiovascular risk factors.
[#Phenylacetylglutamine] - three genera in the #Lachnospiraceae family that were inversely correlated with PAG, were themselves positively correlated with the FRS. - association between PAG and incident CAD is significant in both individuals with high and with low of FRS.
[1.7] [#CVD]
- the abundance of #Bacteroidetes in patients with coronary artery disease (CAD) is lower than that in CAD patients without coronary risk factors or healthy volunteers

References Notes

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↥ Microbiota

‐ Actinobacillus Stool Human [1.8]
‐ Agathobacter Stool Human [1.8]
‐ Akkermansia Stool Human [1.9]
‐ Bacteroides Stool Human [1.10]
‐ Bacteroidetes Stool Human [1.9]
‐ Barnesiellaceae Stool Human [1.9]
‐ Bulleidia Stool Human [1.9]
‐ Butyricimonas Stool Human [1.9]
‐ Catenibacterium Stool Human [1.11]
‐ Christensenellaceae Stool Human [1.9]
‐ Collinsella aerofaciens Stool Human [1.10]
‐ Collinsella Stool Human [1.9]
‐ Comamonas Stool Human [1.9]
‐ Coriobacteriaceae Stool Human [1.9]
‐ Desulfovibrio Stool Human [1.9]
‐ Enhydrobacter Stool Human [1.9]
‐ Enterococcus Stool Human [1.11]
‐ Granulicatella Stool Human [1.12]
‐ Haemophilus Stool Human [1.12]
‐ Klebsiella Stool Human [1.12]
‐ Lactobacillales Stool Human [1.13]
‐ Lactobacillus Stool Human [1.11]
‐ Lactococcus Stool Human [1.11]
‐ Leuconostocaceae Stool Human [1.9]
‐ Megamonas Stool Human [1.10]
‐ Megasphaera Stool Human [1.9]
‐ Odoribacter Stool Human [1.9]
‐ Oxalobacter ↑ Risk Stool Human [1.4]
‐ Parabacteroides distasonis Stool Human [1.10]
‐ Porphyromonas Stool Human [1.8]
‐ Prevotella stercorea Stool Human [1.10]
‐ Prevotella Stool Human [1.8]
‐ Pseudomonas Stool Human [1.11]
‐ Ruminococcus gnavus Stool Human [1.8]
‐ Shewanella Stool Human [1.9]
‐ Shigella Stool Human [1.11]
‐ Sphingobium Stool Human [1.9]
‐ Sphingomonadaceae Stool Human [1.9]
‐ Streptococcus Stool Human [1.12]
‐ Succiniclasticum Stool Human [1.8]
‐ Verrucomicrobium Stool Human [1.9]
‐ Weissella Stool Human [1.11]

↧ Microbiota

‐ Acinetobacter Stool Human [1.8]
‐ Agrobacterium Stool Human [1.9]
‐ Anaerosporobacter Stool Human [1.8]
‐ Bacteroides plebeius Stool Human [1.10]
‐ Bacteroides Stool Human [1.13]
‐ Blautia Stool Human [1.9]
‐ Christensenellaceae Stool Human [1.8]
‐ Clostridiaceae Stool Human [1.10]
‐ Coprococcus Stool Human [1.8]
‐ Delftia Stool Human [1.9]
‐ Dorea Stool Human [1.9]
‐ Eggerthella Stool Human [1.9]
‐ Eisenbergiella Stool Human [1.8]
‐ Enterobacter Stool Human [1.9]
‐ Erysipelotrichaceae Stool Human [1.10]
‐ Eubacterium hallii Stool Human [1.8]
‐ Eubacterium rectale Stool Human [1.11]
‐ Faecalibacterium Stool Human [1.11]
‐ Flavonifractor Stool Human [1.11]
‐ Fournierella Stool Human [1.8]
‐ Fusicatenibacter Stool Human [1.8]
‐ Lachnospiraceae Stool Human [1.11]
‐ Lachnospira Stool Human [1.11]
‐ Morganella Stool Human [1.9]
‐ Roseburia Stool Human [1.11]
‐ Ruminococcaceae Stool Human [1.11]
‐ Ruminococcus gauvreauii Stool Human [1.8]
‐ Staphylococcus Stool Human [1.9]
‐ Streptococcus Stool Human [1.10]
‐ Subdoligranulum Stool Human [1.11]
‐ Veillonella Stool Human [1.8]

Impact by Microbiota

[ ]

↥ Metabolome

‐ asymmetric dimethyl arginine (ADMA) Blood Human
‐ TMAO Causal? Gut Lumen [1.3]
‐ trimethyllysine Causal? Gut Lumen [1.3]

↧ Metabolome

[ ]

Impact by Metabolome

[ ]

Related Factor

[ ]

Subclass

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References

[ ]

MetaBiom
Identifier: 40000234
URL: https://www.metabiom.org/disease/134/coronary-artery-disease
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk [2020] [Review] [Journal of the American College of Cardiology] [Journal] [80001663]
[1.2] Small molecules in the big picture of gut microbiome-host cross-talk - IMPORTANT [2022] [Review] [EBioMedicine] [Journal] [80002422]
[1.3] The double-edged sword of probiotic supplementation on gut microbiota structure in <i>Helicobacter pylori</i> management [2022] [Gut microbes] [Journal] [80002569]
[1.4] Causal associations between gut microbiome and cardiovascular disease: A Mendelian randomization study [2022] [Study] [Frontiers in Cardiovascular Medicine] [Journal] [80002579]
[1.5] Gut microbiome and atrial fibrillation—results from a large population-based study [2023] [Cohort study] [EBioMedicine] [Journal] [80003138]
[1.6] The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease [2020] [Journal of Hypertension] [Journal] [80003606]
[1.7] Differences in the Gastrointestinal Microbiome between Patients with Type A aortic dissection and Patients with Primary Hypertension [2024] [80003848]
[1.8] Coronary artery disease is associated with an altered gut microbiome composition [2020] [PLOS ONE] [Journal] [80001293]
[1.9] Gut microbiome-based diagnostic model to predict coronary artery disease [2020] [Journal of Agricultural and Food Chemistry] [Journal] [80001414]
[1.10] The intestinal microbiota associated with cardiac valve calcification differs from that of coronary artery disease [2019] [Atherosclerosis] [Journal] [80000915]
[1.11] Dysbiosis signatures of gut microbiota in coronary artery disease [2018] [Physiological genomics] [Journal] [80000879]
[1.12] Alterations in the gut microbiome and metabolism with coronary artery disease severity_DUBLICATE [2019] [Microbiome] [Journal] [80001002]
[1.13] Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease [2017] [Heart Vessels] [Journal] [80000400]

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Disease ⇒ Coronary artery disease {40000234}

Record Keys

Details

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References