Disease ⇒ Primary immune thrombocytopenia {40000480} Record Keys Type:Disease Parent:[ ] Definition:Primary immune thrombocytopenia Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10043554 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - fecal bacteria such as #Actinomycetaceae, #Blautia, #Streptococcus, and #Lactobacillus are enriched, whereas bacteria such as #Bacteroides are depleted in ITP patients. - in ITP patients > fecal metabolites such as fatty acyls and #Glycerophospholipids are enriched and strongly correlate with discrepant gut microbiota. - #Lactobacillus might indeed play a key role in the progression of ITP. [#Streptococcus anginosus, #Streptococcus parasanguinis, #Streptococcus salivarius] - #Lactobacillus and #Streptococcus (including S. anginosus, #Streptococcus sp., S. parasanguinis, and S. salivarius) were enriched in ITP patients. [#Streptococcus anginosus] - a strong negative correlation was found between platelet count and altered gut microbiota such as S. anginosus and gut metabolites such as Cer (t18:0/16:0) in ITP. [#Streptococcus anginosus] - S. anginosus not only increased 35-fold in its relative abundance from ITP patients to HCs, but was also highly negatively correlated to platelet count. - combinations of #Weissella and #Streptococcus anginosus, or Cer (t18:0/16:0), Cer (d18:1/17:0), and #13-hydroxyoctadecanoic acid could provide good diagnostic markers for ITP.References Notes[ ]
