Disease ⇒ Cancer ⇒ Bladder cancer {40000147}

Record Keys
Type:	Disease
Parent:	Cancer
Definition:	Bladder cancer

Details
Initialisation date:	2020-09-06
Other Terms:	[ ]

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10005003
MedDra Level:	pt
ICD:	[ ]
Category:	Urology, Oncology
Zone:	[ ]
Mechanism:	[ ]

Notes:

- The most abundant phyla are Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, and Tenericutes.
- The abundance of Proteobacteria was significantly higher among patients who had disease recurrence.
- Firmicutes such as Lactobacillales were more abundant in patients who did not have disease recurrence. (1)

Shared Reference Notes

[1.1]
- #Sulforaphane can normalize the intestinal flora imbalance of bladder cancer mice with a significant increase in #Bacteroides fragilis and #Clostridium cluster I
[1.2] [#Lactobacillus crispatus]
- #Lactobacillus spp were significantly enriched in the #BCG responders. Co-culture with increasing concentrations of #Lactobacillus crispatus resulted in increased #BCG-GFP internalization in UCC when compared to controls
[1.3]
- #Pelomonas > enriched in bladder cancer parenchyma, intestinal mucosa of #Crohn’s disease patients, and non-pregnant women’s endometrium.
[1.4]
- no differences between the urinary microbiome of healthy individuals and patients with bladder cancer, both in alpha and beta diversity
- higher incidence of class #Alphaproteobacteria, order #Rhodospirillales, order #Flavobacteriales, and family #Flavobacteriaceae in female with bladder cancer.
- the #Howardella genus and the #Streptococcus anginosus strain were more common in women. - no differences in the diversity of urine between sexes; however, in the urine of women, there was a higher abundance of the genera #Lactobacillus, Actinotignum, #Prevotella, #Veillonella, and #Campylobacter.
- decreased abundance of #Clostridiales bacterium in the stools of bladder cancer patients, but increased #Streptococcus and #Escherichia.
[#Clostridium group XI] - reduced abundance of #Clostridium cluster XI and #Prevotella in the gut microbiome of patients with bladder cancer.
- #Lactobacillales were more abundant in the urine of patients undergoing #BCG therapy without recurrence, and the order #Enterobacterales was more abundant in the urine of patients with recurrence.
- higher incidence of the genus #Klebsiella in the urine of female patients with bladder cancer.

References Notes

[ ]

↥ Microbiota

‐ Acinetobacter Tissue biopsie Human [1.5]
‐ Acinetobacter Urine Human [1.6]
‐ Actinobaculum massiliense Urine Human [1.7]
‐ Actinomyces europaeus Urine Human [1.8]
‐ Aeromonas Urine Human [1.6]
‐ Anaerococcus Urine Human [1.6]
‐ Anoxybacillus Tissue biopsie Human [1.5]
‐ Atopostipes Urine Human [1.6]
‐ Brucellaceae Tissue biopsie Human [1.5]
‐ Cupriavidus Tissue biopsie Human [1.5]
‐ Facklamia Urine Human [1.7]
‐ Fusobacterium nucleatum Urine Human [1.7]
‐ Fusobacterium Urine Human [1.7]
‐ Geobacillus Tissue biopsie Human [1.5]
‐ Geobacillus Urine Human [1.6]
‐ Jonquetella anthropi Urine Human [1.7]
‐ Pelomonas Tissue biopsie Human [1.5]
‐ Proteobacteria Deteriorative Urinary tract Human
‐ Ralstonia Tissue biopsie Human [1.5]
‐ Roseburia hominis Urine Human [1.7]
‐ Rubrobacter Urine Human [1.6]
‐ Ruminococcaceae Urine Human [1.7]
‐ Shigella Tissue biopsie Human [1.5]
‐ Sphingobacterium Urine Human [1.6]
‐ Sphingomonas Tissue biopsie Human [1.5]
‐ Subdoligranulum Urine Human [1.7]

↧ Microbiota

‐ Bacteroides Urine Human [1.6]
‐ Bifidobacterium Urine Human [1.8]
‐ Corynebacterium appendicis Urine Human [1.7]
‐ Corynebacterium Urine Human [1.7]
‐ Firmicutes Ameliorative Urinary tract Human
‐ Laceyella Urine Human [1.6]
‐ Lactobacillales Ameliorative Urinary tract Human
‐ Lactobacillus Tissue biopsie Human [1.5]
‐ Lactobacillus Urine Human [1.8]
‐ Prevotella Tissue biopsie Human [1.5]
‐ Proteus Urine Human [1.6]
‐ Roseomonas Urine Human [1.6]
‐ Ruminiclostridium Urine Human [1.6]
‐ Ruminococcaceae Tissue biopsie Human [1.5]
‐ Serratia Urine Human [1.6]
‐ Streptococcus cristatus Urine Human [1.7]
‐ Streptococcus Urine Human [1.8]
‐ Veillonella dispar Urine Human [1.7]
‐ Veillonella Urine Human [1.8]

Impact by Microbiota

‐ Lactobacillus crispatus Ameliorative Observational ↥ Live Native Urogenital Human [1.2]

↥ Metabolome

[ ]

↧ Metabolome

[ ]

Impact by Metabolome

[ ]

Related Factor

[ ]

Subclass

[ ]

References

(1) [Report] [2019] Bladder Cancer Response to Bacillus Calmette-Guérin May Be Linked to Urine Microbiome

MetaBiom
Identifier: 40000147
URL: https://www.metabiom.org/disease/48/bladder-cancer
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Composition of intestinal flora affects the risk relationship between Alzheimer’s disease/Parkinson’s disease and cancer [2022] [Review] [Biomedicine & Pharmacotherapy] [Journal] [80002199]
[1.2] PD25-08 THE BLADDER TUMOR MICROBIOME MAY AUGMENT RESPONSE TO BCG IN NON-MUSCLE INVASIVE BLADDER CANCER [2023] [Study] [Journal of Urology] [Journal] [80002930]
[1.3] Longitudinal change of gut microbiota in hypertensive disorders in pregnancy: a nested case–control and Mendelian randomization study [2023] [Scientific Reports] [Journal] [80003534]
[1.4] Is the Urinary and Gut Microbiome Associated With Bladder Cancer? [2023] [Study] [Clinical Medicine Insights: Oncology] [Journal] [80003622]
[1.5] Dysbiosis signatures of the microbial profile in tissue from bladder cancer [2019] [Cancer Medicine] [Journal] [80001272]
[1.6] Profiling the urinary microbiota in male patients with bladder cancer in China_DUBLICATE [2018] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001128]
[1.7] The urinary microbiome associated with bladder cancer [2018] [Scientific Reports] [Journal] [80001102]
[1.8] Urinary microbiota - a potential biomarker and therapeutic target for bladder cancer [2019] [Journal of Medical Microbiology] [Journal] [80001050]

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Disease ⇒ Cancer ⇒ Bladder cancer {40000147}

Record Keys

Details

Links

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References