Disease ⇒ Alcoholic Hepatitis {40000181} Record Keys Type:Disease Parent:[ ] Definition:Alcoholic Hepatitis Details Initialisation date:2020-09-25 Other Terms:[ ] Meta Information MedDra ID:10019717 MedDra Level:pt ICD:[ ] Category:Gastroenterology, DietNutrition, Metabolomics Zone:[ ] Mechanism:[ ] Notes: - Alcoholic hepatitis patients with more severe disease had significantly decreased relative abundances of Akkermansia while the relative abundance of Veillonella was increased. We observed a reduction in the Bacteroides abundance (Padjust = 0.048) and Shannon diversity (Padjust = 0.018) in antibiotic-treated patients and patients receiving steroids had an increase in Veillonella abundance (Padjust = 0.005), which was both independent of potentially confounding factors. (1)Shared Reference Notes [1.1] [#Cornel iridoid glycoside] - CIG could inhibit the activities of AST, ALT and MDA, promote the activities of SOD, CAT and GSH, and reduce oxidative damage to the liver. CIG could significantly alter intestinal microbial diversity, reduce the presence of serum LPS and levels of TNF-α, IL-1β and IL-6 in the liver. In addition, - CIG supplementation reduced the imbalance of intestinal microbiota caused by alcohol and improved intestinal barrier function. [1.2] - #Enterococcus produces cytolysin in subjects with Severe alcohol-associated hepatitis. - The use of phages to target pathogenic bacteria in the gut improves liver inflammation in animal models. - The transfer of alcohol-associated hepatitis via fecal transplant in animal models confirms a major role of Gut Microbiata in the initiation and progression of severe alcoholic liver disease. [1.3] [#Beta-glucan] - #Candidalysin, a peptide toxin secreted by the commensal gut fungus #Candida albicans, was found to enhance alcohol-associated liver disease independent of the β-glucan receptor CLEC7A, and is also associated with worse clinical outcomes in patients with alcoholic hepatitis. [1.4] [#Primary sclerosing cholangitis] - #Veillonella extensively participates in a range of diseases associated with gastrointestinal microbial dysbiosis, for instance, hepatic and gall diseases (#Autoimmune hepatitis, alcoholic hepatitis, #Biliary atresia, and PSC) [1.5] [#Alcoholism] [#Glutamine] - Gln supplementation attenuated #Ethanol-induced mucosal permeability and disruption of tight junctions and adherens junctions in a dose-dependent mannerReferences Notes[ ]
