Disease ⇒ Biliary tract cancer {40000487} Record Keys Type:Disease Parent:[ ] Definition:Biliary tract cancer Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10061008 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Plant-based diet] - High levels of plant dietary fibers in the gut resulted in proliferation of #Bifidobacterium with anti-inflammatory and anti-tumor effects [1.2] - The predominant dysbiotic bacteria in both #Chronic cholecystitis and gallbladder #Cancer were those belonging to the #Enterobacteriaceae family. #Klebsiella increased significantly in the order of normal, #Chronic cholecystitis, and gallbladder #Cancer. [1.3] [#Colorectal cancer, #Esophageal cancer, #Gallbladder cancer, #Pancreatic Cancer] [1.4] [#Intrahepatic Cholangiocarcinoma, #Primary liver cancer] - enriched in ICC were #Actinomyces, #Lactobacillus, #Peptostreptococcaceae, and #Alloscardovia. Furthermore, the #Glycoursodeoxycholic acid and #Tauroursodeoxycholic acid (TUDCA) plasma-stool ratios were significantly increased in ICC with the genera #Lactobacillus and #Alloscardovia exhibiting positive correlations with the TUDCA plasma-stool ratio. - These biomarkers could be used to differentiate ICC from hepatocellular carcinoma (HCC) [#Intrahepatic Cholangiocarcinoma] - Biliary tract cancer intramular microbiome > distinct and tissue-specific microbiome dominated by the families #Dietziaceae, #Pseudomonadaceae, and #Oxalobacteraceae was observed in the bile duct tissues. - #Helicobacter bilis infection activates transcription factors such as NFKB, leading to enhanced angiogenesis through VEGF production. - The involvement of #Helicobacter bilis infection may be significant in biliary tract malignancies [#Helicobacter pylori] - H. pylori has also been linked to an increased risk of biliary tract cancerReferences Notes[ ]
