Lachnospiraceae ⇒ Roseburia {10000139}

Shared Reference Notes

• [1.1] 
  - Roseburia, was found to be reduced in IBD. - It had the highest correlations occurring in a number of bile acids (e.g., taurocholate, taurochenodeoxycholate, glycocholate), in addition to several triacylglycerols (TAGs) and fatty acids. - Specifically, the short chain fatty acid (SCFA) butyrate was found to be positively associated with Roseburia abundance, consistent with known butyrate production in the Roseburia genus. - Roseburia has a known anti-inflammatory role in the intestine and it’s positive association with butyrate is consistent with a deficiency in this genus being highly predictive of IBD.
• [1.2] [#Carbohydrate diet] 
  - Other butyrate producing microbes, e.g. Roseburia spp., fare better when they are delivered #Polysaccharide growth substrates in the diet
• [1.3] [#Saturated fatty acids (SFAs)] 
  - SFAs were positively associated with Roseburia, a biomarker for the lean group.
• [1.4] [#Therapeutic drugs, #β-blocker] 
  - Statins combined with aspirin > synergistic reduction in serum atherogenic lipoproteins. - Diuretic agents combined with beta-blockers > enrichment of intestinal Roseburia
• [1.5] 
  - #Protein powder consumption > decrease in #Lachnospiraceae, Roseburia, #Blautia, Synergistales, #Coprococcus, #Lactobacillales, Bacilli, #Bifidobacterium longum and #Firmicutes. - #Protein powder consumption > higher abundance of #Bacteroidetes.
• [1.6] [#Psychogenic erectile dysfunction] 
  - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased #Prevotella sp.9, #Blautia, #Lachnospiraceae NK4A136 groups and Roseburia.
• [1.7] [#Parkinson’s Disease] 
  - #Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium), #Lachnospiraceae (#Blautia, Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
• [1.8] [#Omega 3] [#Omega 3 Supplementation] 
  - Roseburia may also be enhanced by omega-3 fatty acids in nuts, as its relative abundance was increased in humans as a result of both a walnut-supplemented diet and a diet with the same fatty-acid composition without walnuts
• [1.9] [#Parkinson’s Disease] 
  - lower fecal #Butyrate and reduced counts of genera Roseburia, #Romboutsia, and #Prevotella are related to depressive symptoms in PD patients. - Decreased levels of bacterially produced #Butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms.
• [#Asthma] [#Children] - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium, #Faecalibacterium, #Ruminococcus, and Roseburia) are associated with childhood respiratory diseases.
• [1.11] [#Vegetarian diet] 
  - Dominant species in vegetarians are #Ruminococcus, Roseburia, and #Eubacterium.
• [1.12] [#Infants, #Mother-infant] 
  - Maternal gut strains transmitted after the first 3 months of life included members of the genera #Eubacterium, Roseburia, and #Blautia.
• [1.13] [#Parkinson’s Disease] [#Short Chain Fatty Acid] 
  - PD > a dramatic ~2.5-fold reduction for several SCFA producing species, and as much as 5 to 7.5 fold reduction in Roseburia species.
• [1.14] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] 
  The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) Roseburia, #Eubacterium, #Subdoligranumum, #Ruminococcus - an increase in pro-inflammatory pathogens #Proteus, #Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, #Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus.
• [1.15] [#Multiple Sclerosis] [#Lipocalin-2] 
  - bacteria thought to be beneficial for inflammatory bowel disease (IBD) such as #Anaerobutyricum, #Blautia, and Roseburia, were reduced in fecal Lcn-2-high MS patients.
• [1.16] [#Crohn’s disease] [#Clostridium cluster IV] 
  - Roseburia, #Gemmiger, #Coprococcus, #Ruminococcus 2, #Butyricicoccus, #Dorea, #Fusicatenibacter, #Anaerostipes, Clostridium IV were enriched in the healthy controls. - #Blautia, Clostridium IV, #Coprococcus, #Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between #Dorea, #Butyricicoccus, Roseburia and gland reduce, Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, #Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, #Ruminococcus 2 and clinical symptoms.
• [1.17] 
  - Butyrylated high-amylose maize resistant starch decreased red meat-derived pro-mutagenic adduct O6-methyl-2-deoxyguanosine and related CRC risk. - Certain #Butyrate-producing bacteria such as #Clostridium, #Ruminococcus, #Faecalibacterium spp., #Eubacterium spp., and Roseburia, were found to decrease in relative frequency in CRC patients. - #Butyrate inhibited the growth of CRC cells and induced their apoptosis in vitro at pharmacologically high concentrations.
• [1.18] [#Diabetes Type 2] 
  - A reduction in the #Lachnospira, Roseburia, #Faecalibacterium and #Coprococcus genera in the T2D group. - These genera were #Butyrate producers. - The decrease of these genera favored #Obesity and the development of diseases.
• [1.19] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] 
  - MDD and SZ shared higher levels of #Escherichia/#Shigella and #Veillonella whereas increased #Megasphaera and lower Roseburia are common for BD and SZ.
• [#High-protein diet] - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, #Prevotella, #Ruminococcus, Roseburia, and #Faecalibacterium.
• [1.21] [#Crohn’s disease] 
  - The microbiome risk score (MRS) model yielded a hazard ratio (HR) of 2.24 and temporal validity by capturing individuals that developed CD up to five years prior to disease onset. The five most important taxa contributing to the MRS included #Ruminococcus torques, #Blautia, #Colidextribacter, an uncultured genus-level group from Oscillospiraceace, and Roseburia.
• [1.22] [#Alzheimer’s disease] 
  - Increased proportions of #Odoribacter and #Barnesiella and decreased proportions of #Eubacterium , Roseburia , #Lachnoclostridium and #Collinsella were seen in elders with other #Dementia types than AD.
• [1.23] [#Whole grains] 
  - Several #Butyrate-producers (e.g., #Faecalibacterium, Roseburia, Butyriciococcus) were inversely associated with colonic transit time and/or faecal pH, while the mucin-degraders #Akkermansia and #Ruminococcaceae showed the opposite association.
• [1.24] [#Acute lymphoblastic leukemia] 
  - Roseburia, #Dialister, #Prevotella, #Faecalibacterium and #Anaerostipes showed reduced relative abundance in #Children with ALL at the time of diagnosis
• [#Polysaccharide] - #Cessation of breastfeeding initiates the transition towards an #Adult-like gut microbiome composition, which is characterized by expansion of Roseburia spp. and #Anaerostipes spp., restriction of #Lactobacillus spp. and a functional shift towards an increased capacity to degrade complex polysaccharides
• - delayed maturation of the gut microbiome (characterized by reduced relative abundance of the genera Roseburia, #Dialister, #Prevotella, #Faecalibacterium and #Blautia and increased abundance of #Enterococcus), as well as reduced stool levels of #Butyrate by the age of 12 months, is associated with aberrant immune responses and an increased risk of #Asthma diagnosis by the age of 5 years
• [1.25] [#Faecalibacterium prausnitzii] [#Aging] 
  - older subjects with physical #Frailty and #Sarcopenia > Lower abundance of F. prausnitzii, as well as members of the #Clostridiales class including #Eubacterium and Roseburia genera.
• [#Immune checkpoint inhibitor] - In multiple advanced #Melanoma datasets > Roseburia spp. associated with good response to ICI
• [#Gestational fruit and vegetable consumption, #High fibre diet] - Both total fibre and specific fruit and vegetable fibre intake, are associated with the relative abundance of bacteria of the Clostridia class in the gut microbiome, especially Roseburia genus
• [1.26] 
  - pPobiotic supplementation during #Antibiotic Therapy has a protective effect on #Blautia and Roseburia spp. levels - #Blautia level has a tendency to normalize spontaneously after #Antibiotic Therapy.
• [1.27] [#Systemic lupus erythematosus] 
  - SLE patients displayed higher serum levels of #IL-2 and #IL-6. - The abundance of Roseburia and #Faecalibacterium was inversely correlated with #IL-6, the abundance of Roseburia had a negative correlation with #IL-2, and the abundance of #Bacteroides had a positive correlation with #IL-2.
• [#Systemic lupus erythematosus] - SLE > increased abundance of genera #Candidatus saccharimonas, #Desulfovibrio, #Odoribacter and Roseburia in mice treated with HCMVpp65 peptide is significantly correlated with lupus-like effects including enhanced levels of creatinine, proteinuria, glomerular damage and anti-dsDNA antibodies.
• [1.28] [#High fibre diet] 
  - Both total fibre and specific fruit and vegetable fibre intake, are associated with the relative abundance of bacteria of the #Clostridia class in the gut microbiome, especially Roseburia genus.
• [1.29] [#Inflamatory bowel disease] [#Faecalibacterium prausnitzii] 
  - Decreased abundance on #Firmicutes bacteria belonging to the #Ruminococcaceae spp., #Lachnospiraceae spp, F. prausnitzii and Roseburia spp. families is a signature of microbial dysbiosis in IBD.
• [#Clostridiales XIV, #Clostridium cluster IV] - #Walnut consumption at 42 g/day, increased #Butyrate-producing #Clostridium clusters XIV and IV including, #Faecalibacterium, Roseburia, while lowering the relative abundance of #Ruminococcus, #Dorea, Oscilllo, #Bifidobacteria.
• [#Almond] - almonds (dose of 42 g/day) > increase in the relative amount of #Lachnospira, Roseburia, and #Dialister
• [1.31] 
  - #Riboflavin supplementation increased the abundance of bacteria that cannot synthesize #Riboflavin, such as #Faecalibacterium prausnitzii and Roseburia spp. - Higher intake was also associated with an increase in the abundance of #Prevotella spp.
• [1.32] [#Ulcerative Colitis] [#Short Chain Fatty Acid] 
  - UC > depletion of SCFA-producing #Bacteria such as #Prevotella, Roseburia, #Lachnospiraceae, and #Ruminococcaceae.
• [1.33] [#Pulmonary tubercolosis, #Tuberculosis] 
  - The genera #Parabacteroides, #Bacteroides, #Lachnoclostridium, and #Fusobacterium were markedly enhanced in the PTB group, while Roseburia, #Blautia, unidentified #Ruminococcaceae, #Bifidobacterium, #Romboutsia, and #Fusicatenibacter were enhanced in the HC group.
• [1.34] 
  - Early-stage #Melanoma had a higher alpha diversity, and a higher abundance of the genus Roseburia
• [1.35] [#Clostridium cluster IV, #Clostridium clusters XIVa] [#Butyrate] 
  - The predominant butyrogenic bacterial species, including #Faecalibacterium prausnitzii, #Clostridium spp., #Eubacterium spp., and Roseburia spp., are from two clusters (#Clostridium clusters IV and XIVa) in the #Firmicutes phylum and the #Clostridiales order
• [1.36] [#Parkinson’s Disease] 
  - abundance of #Megasphaera and #Akkermansia, and reduced Roseburia in PD patients
• [1.37] [#Lachnospiraceae] [#Fiber-free diet] 
  - The lack of dietary fiber > reduced abundances of the #Butyrate-producing genera Lachnospiraceaea NK4A136 and Roseburia. Additionally, #Lactobacillus, which was also reduced in Fibre deprived mice
• [1.38] [#Omega 3] 
  - omega-3 rich diet has been shown to result in a significant increase in #Subdoligranulum, along with other #Butyrate producers like #Anaerostipes, #Coprococcus, and Roseburia.
• [#Juvenile idiopathic arthritis] [#Roseburia hominis] - In JIA > reduced #Anaerostipes, #Dialister, #Lachnospira, and Roseburia have been correlated with rheumatic clinical indices including antibodies, erythrocyte sedimentation rate (ESR) and clinical JIA disease activity score. - #Dialister, #Lachnospira, and Roseburia (Roseburia hominis in 0% of ABISJIA) were three of five genera reduced in ABISJIA, as well as an ASV belonging to #Anaerostipes.
• [1.39] [#Obesity] 
  - In obese people, high indigestible carbohydrate intake can significantly increase #Firmicutes bacteria such as Ruminococci, Roseburia, and #Eubacterium rectale, whereas a lack of dietary fermentable carbohydrate intake can significantly decrease #Butyric acid-producing bacteria and, consequently, fecal #Butyric acid content
• [#Exercise training] - Abundance of #Lachnospiraceae (Roseburia and #Lachnospira) has been positively correlated with VO2max and fecal #Butyrate after 2 weeks of high-intensity interval training.
• [1.41] [#Butanoic acid, #Short Chain Fatty Acid] 
  - SCFAs, particularly butanoic and #Acetic acid, can be produced by #Faecalibacterium, Roseburia, #Sutterella, and #Prevotella
• [1.42] [#Cognitive impairment] 
  - genus Roseburia, #Blautia, Catenibacteriu, and #Oxalobacter had a negative impact on cognitive performance, with Roseburia strongly associated with outcome.
• [1.43] [#High fibre diet] 
  - F_NL had more fiber-degrading microorganisms like #Bacteroides thetaiotaomicron, #Bacteroides xylanisolvens, Roseburia sp., #Coprococcus eutactus and #Parabacteroides along with the highest number of genes encoding carbohydrate-active enzymes and gene richness.
• [1.44] [#Depression] 
  - Species of #Coprococcus, #Akkermansia, Roseburia, and #Turicibacter were inversely associated with mood symptoms at age 5.
• - Roseburia also possesses potent anti-inflammatory properties, playing roles in colonic motility and the immune system.
• [1.45] [#Multiple Sclerosis] [#Short Chain Fatty Acid] 
  - the abundances of several of the major short-chain fatty acid (SFCA) producers were decreased (#Prevotella and Roseburia).
• [1.46] [#Anthocyanins] 
  - Subtle differences were observed in the faecal microbiota of subjects that were fed the different apples, with significant reductions in relative abundances of #Streptococcus, #Ruminococcus, #Blautia, and Roseburia, and increased relative abundances of #Sutterella, #Butyricicoccus, and #Lactobacillus in subjects after consuming the red #Apple. - anthocyanin-rich apples may influence immune function compared to control apples
• [1.47] [#Alcohol Consumption] 
  - the alcohol group had higher #Lactobacillus and Roseburia
• [1.48] [#Bipolar disorder] 
  - #Betaproteobacteria, #Acidaminococcaceae, #Eubacterium xylanophilum group, #Butyricimonas, #Peptococcus, #Prevotella 7, Roseburia, #Terrisporobacter, #Burkholderiales and #Desulfovibrionales increased the risk of BD

References Notes