Probiotic (Bifidobacter and Lactobacilus) {50000117}

Shared Notes

• [1.2] 
  The probiotics improve ( Bifidobacterium (eg, B. longum, B. breve , and B. infantis ) and Lactobacillus (eg, L. helveticus , and L. rhamnosus ) psychiatric disorder-related behaviors including anxiety, depression, autism spectrum disorder (ASD), obsessive-compulsive disorder, and memory abilities, including spatial and non-spatial memory.
• [1.3] 
  - The administration of a probiotic cocktail, composed of Lactobacillus rhamnosus and Lactobacillus helveticus, reduced the symptoms of depression and anxiety
• [1.4] 
  - Certain probiotic bacteria reportedly demonstrated effects in suppressing and regressing cancer.
  - Their mechanisms include maintaining physicochemical conditions in the colon (e.g., pH and bile acid profile), balancing the quantity of beneficial gut microbiota members through the production of short-chain fatty acids, reducing the abundance of putrefactive bacteria producing enzymes such as azoreductase, β-glucosidase, β-glucuronidase, and nitroreductase, binding and degrading mutagenic compounds, as well as performing immunomodulatory activities.
  - Experimentations with wild-type probiotics have been performed against not only colorectal cancer, but also other cancers such as bladder, breast, cervical, and liver cancers.
  - Instead of oral administration, probiotics can also be delivered locally at tumor sites, which can reduce non-specific pharmacological effects on non-tumor tissues.
• [1.5] 
  - Bacteria present in probiotics, particularly the common Lactobacillus and Bifidobacterium microbes, have been found to induce anti-cancer action by enhancing cancer cell apoptosis and protecting against oxidative stress.
  - Probiotics supplements also decrease the cancer-producing microorganism Fusobacterium.
• [1.6] 
  - Probiotic supplementation > significantly reduced the severity of nausea, vomiting, constipation, and improved life quality in pregnant women.
  - Probiotic intake increased fecal bsh (bile salt hydrolase) > free bile acids > facilitate intestinal mobility and metabolism > associated with lower vomiting scores.
  
  
• [1.7] 
  -Lactobacillus salivarius and Bifidobacterium infantis >Transepithelial calcium transport >Enhanced intestinal calcium uptake
• [1.8] 
  - Probiotic > Covid-19 > The proportion who developed symptoms was 26.4% with LGG versus 42.9% with placebo, a significant difference.
• [1.1] 
  - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks.
  > improvement in sleep quality.
  - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels.
  - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition.